Prevalence and risk factors of dry eye syndrome in a United States Veterans Affairs population

Anat Galor, William J Feuer, David J Lee, Hermes J Florez, David Carter, Bozorgmehr Pouyeh, William J. Prunty, Victor L Perez Quinones

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Purpose: To evaluate the prevalence of dry eye syndrome (DES) and its associated risk factors in a US Veterans Affairs population receiving ocular care services. Design: Retrospective study. Methods: settings: Patients were seen in the Miami and Broward Veterans Affairs eye clinics between 2005 and 2010. patients population: Patients were divided into cases and controls with regard to their dry eye status (cases = ICD9 code for DES plus dry eye therapy; controls = patients without ICD9 code plus no therapy). main outcome measures: The prevalence of DES and its associated risk factors. Results: A total of 16 862 patients were identified as either a dry eye case (n = 2056) or control (n = 14 806). Overall, 12% of male and 22% of female patients had a diagnosis of DES, with female gender imparting a 2.40 increased risk (95% confidence interval [CI] 2.042.81) over male gender. Several medical conditions were found to increase DES risk including post-traumatic stress disorder (odds ratio [OR] 1.97, 95% CI 1.752.23), depression (OR 1.91, 95% CI 1.732.10), thyroid disease (OR 1.81, 95% CI 1.462.26), and sleep apnea (OR 2.20, 95% CI 1.972.46) (all analyses adjusted for gender and age). The use of several systemic medications, including anti-depressant medications (OR 1.97, 95% CI 1.792.17), anti-anxiety medication (OR 1.74, 95% CI 1.581.91), and antibenign prostatic hyperplasia medications (OR 1.68, 95% CI 1.511.86), was likewise associated with an increased risk of DES. Conclusions: The prevalence of DES was found to be high in both men and women in our eye care population. This is the first study to demonstrate that in a veteran population, several diagnoses were significantly associated with DES, including post-traumatic stress disorder and depression.

Original languageEnglish
Pages (from-to)377-384
Number of pages8
JournalAmerican Journal of Ophthalmology
Volume152
Issue number3
DOIs
StatePublished - Sep 1 2011

Fingerprint

Dry Eye Syndromes
Veterans
Confidence Intervals
Odds Ratio
Population
Post-Traumatic Stress Disorders
Depression
United States Department of Veterans Affairs
Thyroid Diseases
Sleep Apnea Syndromes
Prostatic Hyperplasia
Anxiety
Retrospective Studies
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Prevalence and risk factors of dry eye syndrome in a United States Veterans Affairs population. / Galor, Anat; Feuer, William J; Lee, David J; Florez, Hermes J; Carter, David; Pouyeh, Bozorgmehr; Prunty, William J.; Perez Quinones, Victor L.

In: American Journal of Ophthalmology, Vol. 152, No. 3, 01.09.2011, p. 377-384.

Research output: Contribution to journalArticle

Galor, Anat ; Feuer, William J ; Lee, David J ; Florez, Hermes J ; Carter, David ; Pouyeh, Bozorgmehr ; Prunty, William J. ; Perez Quinones, Victor L. / Prevalence and risk factors of dry eye syndrome in a United States Veterans Affairs population. In: American Journal of Ophthalmology. 2011 ; Vol. 152, No. 3. pp. 377-384.
@article{48e76f48c7044f8997928d72386939d1,
title = "Prevalence and risk factors of dry eye syndrome in a United States Veterans Affairs population",
abstract = "Purpose: To evaluate the prevalence of dry eye syndrome (DES) and its associated risk factors in a US Veterans Affairs population receiving ocular care services. Design: Retrospective study. Methods: settings: Patients were seen in the Miami and Broward Veterans Affairs eye clinics between 2005 and 2010. patients population: Patients were divided into cases and controls with regard to their dry eye status (cases = ICD9 code for DES plus dry eye therapy; controls = patients without ICD9 code plus no therapy). main outcome measures: The prevalence of DES and its associated risk factors. Results: A total of 16 862 patients were identified as either a dry eye case (n = 2056) or control (n = 14 806). Overall, 12{\%} of male and 22{\%} of female patients had a diagnosis of DES, with female gender imparting a 2.40 increased risk (95{\%} confidence interval [CI] 2.042.81) over male gender. Several medical conditions were found to increase DES risk including post-traumatic stress disorder (odds ratio [OR] 1.97, 95{\%} CI 1.752.23), depression (OR 1.91, 95{\%} CI 1.732.10), thyroid disease (OR 1.81, 95{\%} CI 1.462.26), and sleep apnea (OR 2.20, 95{\%} CI 1.972.46) (all analyses adjusted for gender and age). The use of several systemic medications, including anti-depressant medications (OR 1.97, 95{\%} CI 1.792.17), anti-anxiety medication (OR 1.74, 95{\%} CI 1.581.91), and antibenign prostatic hyperplasia medications (OR 1.68, 95{\%} CI 1.511.86), was likewise associated with an increased risk of DES. Conclusions: The prevalence of DES was found to be high in both men and women in our eye care population. This is the first study to demonstrate that in a veteran population, several diagnoses were significantly associated with DES, including post-traumatic stress disorder and depression.",
author = "Anat Galor and Feuer, {William J} and Lee, {David J} and Florez, {Hermes J} and David Carter and Bozorgmehr Pouyeh and Prunty, {William J.} and {Perez Quinones}, {Victor L}",
year = "2011",
month = "9",
day = "1",
doi = "10.1016/j.ajo.2011.02.026",
language = "English",
volume = "152",
pages = "377--384",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "3",

}

TY - JOUR

T1 - Prevalence and risk factors of dry eye syndrome in a United States Veterans Affairs population

AU - Galor, Anat

AU - Feuer, William J

AU - Lee, David J

AU - Florez, Hermes J

AU - Carter, David

AU - Pouyeh, Bozorgmehr

AU - Prunty, William J.

AU - Perez Quinones, Victor L

PY - 2011/9/1

Y1 - 2011/9/1

N2 - Purpose: To evaluate the prevalence of dry eye syndrome (DES) and its associated risk factors in a US Veterans Affairs population receiving ocular care services. Design: Retrospective study. Methods: settings: Patients were seen in the Miami and Broward Veterans Affairs eye clinics between 2005 and 2010. patients population: Patients were divided into cases and controls with regard to their dry eye status (cases = ICD9 code for DES plus dry eye therapy; controls = patients without ICD9 code plus no therapy). main outcome measures: The prevalence of DES and its associated risk factors. Results: A total of 16 862 patients were identified as either a dry eye case (n = 2056) or control (n = 14 806). Overall, 12% of male and 22% of female patients had a diagnosis of DES, with female gender imparting a 2.40 increased risk (95% confidence interval [CI] 2.042.81) over male gender. Several medical conditions were found to increase DES risk including post-traumatic stress disorder (odds ratio [OR] 1.97, 95% CI 1.752.23), depression (OR 1.91, 95% CI 1.732.10), thyroid disease (OR 1.81, 95% CI 1.462.26), and sleep apnea (OR 2.20, 95% CI 1.972.46) (all analyses adjusted for gender and age). The use of several systemic medications, including anti-depressant medications (OR 1.97, 95% CI 1.792.17), anti-anxiety medication (OR 1.74, 95% CI 1.581.91), and antibenign prostatic hyperplasia medications (OR 1.68, 95% CI 1.511.86), was likewise associated with an increased risk of DES. Conclusions: The prevalence of DES was found to be high in both men and women in our eye care population. This is the first study to demonstrate that in a veteran population, several diagnoses were significantly associated with DES, including post-traumatic stress disorder and depression.

AB - Purpose: To evaluate the prevalence of dry eye syndrome (DES) and its associated risk factors in a US Veterans Affairs population receiving ocular care services. Design: Retrospective study. Methods: settings: Patients were seen in the Miami and Broward Veterans Affairs eye clinics between 2005 and 2010. patients population: Patients were divided into cases and controls with regard to their dry eye status (cases = ICD9 code for DES plus dry eye therapy; controls = patients without ICD9 code plus no therapy). main outcome measures: The prevalence of DES and its associated risk factors. Results: A total of 16 862 patients were identified as either a dry eye case (n = 2056) or control (n = 14 806). Overall, 12% of male and 22% of female patients had a diagnosis of DES, with female gender imparting a 2.40 increased risk (95% confidence interval [CI] 2.042.81) over male gender. Several medical conditions were found to increase DES risk including post-traumatic stress disorder (odds ratio [OR] 1.97, 95% CI 1.752.23), depression (OR 1.91, 95% CI 1.732.10), thyroid disease (OR 1.81, 95% CI 1.462.26), and sleep apnea (OR 2.20, 95% CI 1.972.46) (all analyses adjusted for gender and age). The use of several systemic medications, including anti-depressant medications (OR 1.97, 95% CI 1.792.17), anti-anxiety medication (OR 1.74, 95% CI 1.581.91), and antibenign prostatic hyperplasia medications (OR 1.68, 95% CI 1.511.86), was likewise associated with an increased risk of DES. Conclusions: The prevalence of DES was found to be high in both men and women in our eye care population. This is the first study to demonstrate that in a veteran population, several diagnoses were significantly associated with DES, including post-traumatic stress disorder and depression.

UR - http://www.scopus.com/inward/record.url?scp=80051865559&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80051865559&partnerID=8YFLogxK

U2 - 10.1016/j.ajo.2011.02.026

DO - 10.1016/j.ajo.2011.02.026

M3 - Article

C2 - 21684522

AN - SCOPUS:80051865559

VL - 152

SP - 377

EP - 384

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

IS - 3

ER -