Prevalence and prognosis of coexistent asymptomatic intracranial stenosis

Fadi Nahab, George Cotsonis, Michael Lynn, Edward Feldmann, Seemant Chaturvedi, J. Claude Hemphill, Richard Zweifler, Karen Johnston, David Bonovich, Scott Kasner, Marc Chimowitz

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


BACKGROUND AND PURPOSE - There are limited data on the prevalence and prognosis of asymptomatic intracranial stenosis (AIS). METHODS - Baseline cerebral angiograms and MR angiograms were used to determine AIS (50% to 99%) coexistent to symptomatic intracranial stenosis for patients enrolled in the Warfarin-Aspirin Symptomatic Intracranial Disease study. RESULTS - Coexisting AIS were detected in 18.9% (n=14/74) of patients undergoing 4-vessel cerebral angiography and 27.3% (n=65/238) of patients undergoing MR angiogram. During a mean follow-up period of 1.8 years, no ischemic strokes were attributable to an AIS on cerebral angiography and 5 ischemic strokes (5.9%, 95% CI: 2.1% to 12.3%) occurred in the AIS territory on MR angiogram (risk at 1 year=3.5%, 95% CI: 0.8% to 9.0%). CONCLUSIONS - Whereas the prevalence of coexisting AIS (50% to 99%) in patients with symptomatic stenosis is high, the risk of stroke from these asymptomatic stenoses is low.

Original languageEnglish (US)
Pages (from-to)1039-1041
Number of pages3
Issue number3
StatePublished - Mar 2008
Externally publishedYes


  • Atherosclerosis
  • Diabetes
  • Intracranial disease
  • Intracranial stenosis
  • Prognosis
  • Risk factors
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


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