Prevalence and prognosis of coexistent asymptomatic intracranial stenosis

Fadi Nahab, George Cotsonis, Michael Lynn, Edward Feldmann, Seemant Chaturvedi, J. Claude Hemphill, Richard Zweifler, Karen Johnston, David Bonovich, Scott Kasner, Marc Chimowitz

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE - There are limited data on the prevalence and prognosis of asymptomatic intracranial stenosis (AIS). METHODS - Baseline cerebral angiograms and MR angiograms were used to determine AIS (50% to 99%) coexistent to symptomatic intracranial stenosis for patients enrolled in the Warfarin-Aspirin Symptomatic Intracranial Disease study. RESULTS - Coexisting AIS were detected in 18.9% (n=14/74) of patients undergoing 4-vessel cerebral angiography and 27.3% (n=65/238) of patients undergoing MR angiogram. During a mean follow-up period of 1.8 years, no ischemic strokes were attributable to an AIS on cerebral angiography and 5 ischemic strokes (5.9%, 95% CI: 2.1% to 12.3%) occurred in the AIS territory on MR angiogram (risk at 1 year=3.5%, 95% CI: 0.8% to 9.0%). CONCLUSIONS - Whereas the prevalence of coexisting AIS (50% to 99%) in patients with symptomatic stenosis is high, the risk of stroke from these asymptomatic stenoses is low.

Original languageEnglish (US)
Pages (from-to)1039-1041
Number of pages3
JournalStroke
Volume39
Issue number3
DOIs
StatePublished - Mar 2008
Externally publishedYes

Fingerprint

Pathologic Constriction
Angiography
Cerebral Angiography
Stroke
Warfarin
Aspirin

Keywords

  • Atherosclerosis
  • Diabetes
  • Intracranial disease
  • Intracranial stenosis
  • Prognosis
  • Risk factors
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)
  • Medicine(all)

Cite this

Nahab, F., Cotsonis, G., Lynn, M., Feldmann, E., Chaturvedi, S., Hemphill, J. C., ... Chimowitz, M. (2008). Prevalence and prognosis of coexistent asymptomatic intracranial stenosis. Stroke, 39(3), 1039-1041. https://doi.org/10.1161/STROKEAHA.107.499475

Prevalence and prognosis of coexistent asymptomatic intracranial stenosis. / Nahab, Fadi; Cotsonis, George; Lynn, Michael; Feldmann, Edward; Chaturvedi, Seemant; Hemphill, J. Claude; Zweifler, Richard; Johnston, Karen; Bonovich, David; Kasner, Scott; Chimowitz, Marc.

In: Stroke, Vol. 39, No. 3, 03.2008, p. 1039-1041.

Research output: Contribution to journalArticle

Nahab, F, Cotsonis, G, Lynn, M, Feldmann, E, Chaturvedi, S, Hemphill, JC, Zweifler, R, Johnston, K, Bonovich, D, Kasner, S & Chimowitz, M 2008, 'Prevalence and prognosis of coexistent asymptomatic intracranial stenosis', Stroke, vol. 39, no. 3, pp. 1039-1041. https://doi.org/10.1161/STROKEAHA.107.499475
Nahab, Fadi ; Cotsonis, George ; Lynn, Michael ; Feldmann, Edward ; Chaturvedi, Seemant ; Hemphill, J. Claude ; Zweifler, Richard ; Johnston, Karen ; Bonovich, David ; Kasner, Scott ; Chimowitz, Marc. / Prevalence and prognosis of coexistent asymptomatic intracranial stenosis. In: Stroke. 2008 ; Vol. 39, No. 3. pp. 1039-1041.
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AU - Hemphill, J. Claude

AU - Zweifler, Richard

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