Prevalence and patterns of self-initiated nutritional supplementation in men at high risk of prostate cancer

R. G. Uzzo, J. G. Brown, E. M. Horwitz, A. Hanlon, S. Mazzoni, A. Konski, R. E. Greenberg, Alan Pollack, V. Kolenko, D. Watkins-Bruner

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

OBJECTIVE: To define the prevalence and patterns of self-initiated herbal and vitamin supplementation among men at high risk of developing prostate cancer, as there is increasing public awareness of prostate cancer screening, risk-factor assessment and prevention, leading to increasing interest in the use and systematic study of nutritional therapies for prostate cancer prevention. SUBJECTS AND METHODS: Since 1996 our institution has prospectively maintained a prostate cancer-risk registry through its Prostate Cancer Risk Assessment Program (PRAP). Eligibility includes African-American men, any man with at least one first-degree relative or two or more second-degree relatives with prostate cancer, or men who tested positively for the BRCA1 gene mutation. A 420-item self-administered-questionnaire was completed and included the use of nutritional supplements and complementary therapies. We divided men into groups who used supplements to lessen their cancer risk and those who did not. The prevalence and patterns of use were evaluated and the two groups then compared for differences in demographic, socioeconomic and risk-perception variables. RESULTS: In all, 345 high-risk men were enrolled in the PRAP over a 5-year period. Data on the use of dietary or herbal supplements were available on 333 men (97%), of whom over half (170) reported taking one or more supplements to prevent prostate cancer. Supplement use was divided into eight categories, including vitamins, minerals, extracts from fruits/seeds, organic compounds, flowers/bulbs, leaves/ bark, roots, or animal products. Most commonly used for self-initiated chemoprevention were vitamins (95%), minerals (28%), and fruit/seed extracts (18%). More than a quarter of men (27%) took three or more agents. Men taking proactive preventative measures were statistically more likely to be Caucasian and aged >60 years (P<0.05). African-Americans were less likely to self-initiate preventative steps. Men taking supplements tended to return more often for follow-up and participate in PRAP longer, while those not taking supplements tended to earn less and report less self-perceived risk. CONCLUSIONS: A significant proportion of men at risk of developing prostate cancer initiate measures they perceive to reduce their risk. Although the chemopreventative efficacy of many of these supplements remains unsubstantiated, they are widely perceived by the public to reduce the risk of developing prostate cancer. These data provide an insight into patient perceptions and misconceptions of chemopreventative strategies, and may help to refine recruitment efforts in multiinstitutional prostate cancer prevention trials.

Original languageEnglish
Pages (from-to)955-960
Number of pages6
JournalBJU International
Volume93
Issue number7
DOIs
StatePublished - May 1 2004
Externally publishedYes

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Prostatic Neoplasms
Vitamins
African Americans
Minerals
Fruit
Seeds
BRCA1 Gene
Chemoprevention
Complementary Therapies
Early Detection of Cancer
Self Report
Registries
Demography
Mutation

Keywords

  • Cancer
  • Nutrition
  • Prevention
  • Prostate
  • Supplement

ASJC Scopus subject areas

  • Urology

Cite this

Uzzo, R. G., Brown, J. G., Horwitz, E. M., Hanlon, A., Mazzoni, S., Konski, A., ... Watkins-Bruner, D. (2004). Prevalence and patterns of self-initiated nutritional supplementation in men at high risk of prostate cancer. BJU International, 93(7), 955-960. https://doi.org/10.1111/j.1464-410X.2004.04759.x

Prevalence and patterns of self-initiated nutritional supplementation in men at high risk of prostate cancer. / Uzzo, R. G.; Brown, J. G.; Horwitz, E. M.; Hanlon, A.; Mazzoni, S.; Konski, A.; Greenberg, R. E.; Pollack, Alan; Kolenko, V.; Watkins-Bruner, D.

In: BJU International, Vol. 93, No. 7, 01.05.2004, p. 955-960.

Research output: Contribution to journalArticle

Uzzo, RG, Brown, JG, Horwitz, EM, Hanlon, A, Mazzoni, S, Konski, A, Greenberg, RE, Pollack, A, Kolenko, V & Watkins-Bruner, D 2004, 'Prevalence and patterns of self-initiated nutritional supplementation in men at high risk of prostate cancer', BJU International, vol. 93, no. 7, pp. 955-960. https://doi.org/10.1111/j.1464-410X.2004.04759.x
Uzzo, R. G. ; Brown, J. G. ; Horwitz, E. M. ; Hanlon, A. ; Mazzoni, S. ; Konski, A. ; Greenberg, R. E. ; Pollack, Alan ; Kolenko, V. ; Watkins-Bruner, D. / Prevalence and patterns of self-initiated nutritional supplementation in men at high risk of prostate cancer. In: BJU International. 2004 ; Vol. 93, No. 7. pp. 955-960.
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AU - Horwitz, E. M.

AU - Hanlon, A.

AU - Mazzoni, S.

AU - Konski, A.

AU - Greenberg, R. E.

AU - Pollack, Alan

AU - Kolenko, V.

AU - Watkins-Bruner, D.

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N2 - OBJECTIVE: To define the prevalence and patterns of self-initiated herbal and vitamin supplementation among men at high risk of developing prostate cancer, as there is increasing public awareness of prostate cancer screening, risk-factor assessment and prevention, leading to increasing interest in the use and systematic study of nutritional therapies for prostate cancer prevention. SUBJECTS AND METHODS: Since 1996 our institution has prospectively maintained a prostate cancer-risk registry through its Prostate Cancer Risk Assessment Program (PRAP). Eligibility includes African-American men, any man with at least one first-degree relative or two or more second-degree relatives with prostate cancer, or men who tested positively for the BRCA1 gene mutation. A 420-item self-administered-questionnaire was completed and included the use of nutritional supplements and complementary therapies. We divided men into groups who used supplements to lessen their cancer risk and those who did not. The prevalence and patterns of use were evaluated and the two groups then compared for differences in demographic, socioeconomic and risk-perception variables. RESULTS: In all, 345 high-risk men were enrolled in the PRAP over a 5-year period. Data on the use of dietary or herbal supplements were available on 333 men (97%), of whom over half (170) reported taking one or more supplements to prevent prostate cancer. Supplement use was divided into eight categories, including vitamins, minerals, extracts from fruits/seeds, organic compounds, flowers/bulbs, leaves/ bark, roots, or animal products. Most commonly used for self-initiated chemoprevention were vitamins (95%), minerals (28%), and fruit/seed extracts (18%). More than a quarter of men (27%) took three or more agents. Men taking proactive preventative measures were statistically more likely to be Caucasian and aged >60 years (P<0.05). African-Americans were less likely to self-initiate preventative steps. Men taking supplements tended to return more often for follow-up and participate in PRAP longer, while those not taking supplements tended to earn less and report less self-perceived risk. CONCLUSIONS: A significant proportion of men at risk of developing prostate cancer initiate measures they perceive to reduce their risk. Although the chemopreventative efficacy of many of these supplements remains unsubstantiated, they are widely perceived by the public to reduce the risk of developing prostate cancer. These data provide an insight into patient perceptions and misconceptions of chemopreventative strategies, and may help to refine recruitment efforts in multiinstitutional prostate cancer prevention trials.

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KW - Nutrition

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