TY - JOUR
T1 - Prevalence and Mechanisms of Carbapenem Resistance in Klebsiella pneumoniae and Escherichia coli
T2 - A Systematic Review and Meta-Analysis of Cross-Sectional Studies from Iran
AU - Nasiri, Mohammad Javad
AU - Mirsaeidi, Mehdi
AU - Mousavi, Seyyed Mohammad Javad
AU - Arshadi, Mania
AU - Fardsanei, Fatemeh
AU - Deihim, Behnaz
AU - Davoudabadi, Sara
AU - Zamani, Samin
AU - Hajikhani, Bahareh
AU - Goudarzi, Hossein
AU - Goudarzi, Mehdi
AU - Seghatoleslami, Zahra Sadat
AU - Dabiri, Hossein
AU - Tabarsi, Payam
N1 - Funding Information:
This study was supported by Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Publisher Copyright:
© 2020, Mary Ann Liebert, Inc., publishers 2020.
PY - 2020/12
Y1 - 2020/12
N2 - Introduction: Carbapenem-resistant Enterobacteriaceae (CRE) represents an urgent threat worldwide. We aimed to investigate the frequency of carbapenem-resistant Klebsiella pneumoniae and Escherichia coli in Iran. Materials and Methods: PubMed/Medline, Embase, Scopus, Web of Sciences, and Iranian databases were searched to find potentially relevant articles. Statistical analyses were performed using STATA version 14. Results: Forty-nine studies fulfilled the inclusion criteria. The pooled rates of resistance to carbapenem in K. pneumoniae and E. coli were 24.0% (95% confidence interval [CI] 18.0-31.0) and 5.0% (95% CI 2.0-8.0), respectively. blaOXA-48 gene was the most common cause of carbapenem resistance in K. pneumoniae and E. coli. Conclusions: CRE is prevalent in Iran, which confers the importance of strength prevention and control measures.
AB - Introduction: Carbapenem-resistant Enterobacteriaceae (CRE) represents an urgent threat worldwide. We aimed to investigate the frequency of carbapenem-resistant Klebsiella pneumoniae and Escherichia coli in Iran. Materials and Methods: PubMed/Medline, Embase, Scopus, Web of Sciences, and Iranian databases were searched to find potentially relevant articles. Statistical analyses were performed using STATA version 14. Results: Forty-nine studies fulfilled the inclusion criteria. The pooled rates of resistance to carbapenem in K. pneumoniae and E. coli were 24.0% (95% confidence interval [CI] 18.0-31.0) and 5.0% (95% CI 2.0-8.0), respectively. blaOXA-48 gene was the most common cause of carbapenem resistance in K. pneumoniae and E. coli. Conclusions: CRE is prevalent in Iran, which confers the importance of strength prevention and control measures.
KW - Escherichia coli
KW - Iran
KW - Klebsiella pneumoniae
KW - carbapenem resistance
UR - http://www.scopus.com/inward/record.url?scp=85097498963&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85097498963&partnerID=8YFLogxK
U2 - 10.1089/mdr.2019.0440
DO - 10.1089/mdr.2019.0440
M3 - Article
C2 - 32348701
AN - SCOPUS:85097498963
VL - 26
SP - 1491
EP - 1502
JO - Microbial Drug Resistance
JF - Microbial Drug Resistance
SN - 1076-6294
IS - 12
ER -