Prevalence and factors associated with fixed-dose combination antiretroviral drugs adherence among HIV-positive pregnant women on option b treatment in Mpumalanga province, South Africa

Shandir Ramlagan, Karl Peltzer, Robert A.C. Ruiter, Nicole A. Barylski, Stephen M Weiss, Sibusiso Sifunda

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The possibility for all babies to be born and remain HIV-negative for the first year of life is achievable in South Africa. HIV-positive mothers’ adherence to their antiretroviral medication is one of the crucial factors to achieve this target. Cross-sectional data were collected at 12 community health centres, over 12 months (2014–2015), from 673 HIV-positive women, less than 6 months pregnant, attending antenatal care, and on Option B treatment. Adherence measures included the Adults AIDS Clinical Trials Group (AACTG) four-day measure, as well as the Visual Analog Scale (VAS) seven-day measure. Bivariate analyses and multivariate logistic regressions are presented. 78.8% of respondents were adherent on AACTG, while 68.8% reported VAS adherence. Bivariate analyses for increased adherence show significant associations with older age, less/no alcohol usage, disclosure of HIV status, higher HIV knowledge, no desire to avoid ARV side effects, low stigma, and low depression. AACTG showed a negative association with intimate partner violence. Multivariable logistic regression on AACTG and VAS adherence rates resulted in unique contributions to increased adherence of older age, less/no alcohol usage, higher HIV knowledge, lack of depression, and non-disclosure. Programs targeting closer side effect monitoring, HIV disclosure, pre-natal depression, alcohol intake, and HIV knowledge need consideration.

Original languageEnglish (US)
Article number161
JournalInternational Journal of Environmental Research and Public Health
Volume15
Issue number1
DOIs
StatePublished - Jan 20 2018

Fingerprint

Drug Combinations
South Africa
Pregnant Women
HIV
Acquired Immunodeficiency Syndrome
Visual Analog Scale
Clinical Trials
Alcohols
Disclosure
Therapeutics
Depression
Logistic Models
Community Health Centers
Prenatal Care
Multivariate Analysis
Mothers

Keywords

  • Adherence
  • ARVs
  • HIV/AIDS
  • Option B
  • Pregnant

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Prevalence and factors associated with fixed-dose combination antiretroviral drugs adherence among HIV-positive pregnant women on option b treatment in Mpumalanga province, South Africa. / Ramlagan, Shandir; Peltzer, Karl; Ruiter, Robert A.C.; Barylski, Nicole A.; Weiss, Stephen M; Sifunda, Sibusiso.

In: International Journal of Environmental Research and Public Health, Vol. 15, No. 1, 161, 20.01.2018.

Research output: Contribution to journalArticle

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