Pretibial Myxedema Masquerading as a Venous Leg Ulcer

Ingrid Herskovitz, Olivia Hughes, Flor MacQuhae, Robert Kirsner

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The authors report a case of pretibial myxedema (PTM) masquerading as a venous leg ulcer to alert wound care clinicians to this diagnostic possibility. Pretibial myxedema is a localized form of mucin cutaneous deposition characterized by indurated plaques most commonly on anterior legs. It is more likely to present in patients with Graves' disease, but it can be found in euthyroid patients as well. The physiopathology of PTM is complex, and there is an accumulation of highly hydrophilic glycosaminoglycans in the dermis. Minimal morbidity is associated with PTM, but the pruritus related to mucin deposition can be intense. The skin around venous leg ulcers and the skin changes related to PTM can have a similar clinical presentation, which may be a reason PTM is under-recognized.

Original languageEnglish (US)
Pages (from-to)77-79
Number of pages3
Issue number3
StatePublished - Mar 1 2017


  • lower extremity
  • Pretibial myxedema
  • venous leg ulcer

ASJC Scopus subject areas

  • Surgery
  • Medical–Surgical


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