Preterm infants: Ventilation and P100 changes with CO2 and inspiratory resistive loading

S. Duara, S. Abbasi, T. H. Shaffer, W. W. Fox

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The ventilatory effects of inspiratory flow-resistive loading and increased chemical drive were measured in ten neonates during progressive hypercapnia in control and loaded states. Hypercapnia (mean increase P(CO2) = 15-20) resulted from inspiring 8% CO2 in room air and inspiratory loading by a flow-resistive load = 100 cmH2O·l-1.·s. Hypercapnia produced an increase in group minute ventilation secondary to increasing tidal volumes and breathing frequencies. Loading shifted the minute ventilation-CO2 response to the right, and slopes decreased significantly (P < 0.05) consequent to a significant decrease in the frequency-CO2 slopes (P < 0.05), which became negative in four of the ten subjects. Mouth pressure measured at 100 ms after onset of inspiratory effort (P100) occlusion pressure-CO2 slopes measured in five subjects showed no significant increase with load application. Resistive loading produced significant increases in inspiratory time (P < 0.02) and the inspiratory time/total breath time ratio (P < 0.01). Airway occlusion elicited the Hering-Breuer reflex, with a significant increase in inspiratory time-to-total breath time ratio (P < 0.01). The results show that the inspiratory resistive load produced ventilatory compromise in newborns and insufficient compensatory augmentation of central drive.

Original languageEnglish (US)
Pages (from-to)1982-1987
Number of pages6
JournalJournal of applied physiology
Issue number6
StatePublished - Jan 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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