Presynaptic: Mitochondria and Presynaptic Function

G. David

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Motor nerve terminals must be prepared for sudden increases in energy demand associated with vesicular release and recycling. This article summarizes studies using functional fluorescence imaging and electrophysiological recording that demonstrate that vertebrate motor terminals rely on their abundant mitochondria not only for adenosine triphosphate production but also for efficient, sustained sequestration of large stimulation-induced Ca2+ loads. Ca2+ influx into the mitochondria is essential for sustaining neuromuscular transmission during repetitive stimulation and is a major stimulant for mitochondrial respiration in motor terminals. Their heavy reliance on mitochondria may make motor terminals especially vulnerable to stresses and diseases that impair mitochondrial function.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages1025-1035
Number of pages11
ISBN (Print)9780080450469
DOIs
StatePublished - Jan 1 2009

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

David, G. (2009). Presynaptic: Mitochondria and Presynaptic Function. In Encyclopedia of Neuroscience (pp. 1025-1035). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.01278-X