TY - JOUR
T1 - Preservative Sensitization—Safety With and Safety Without
AU - Hughes, Olivia B.
AU - Maderal, Andrea D.
AU - Tosti, Antonella
N1 - Publisher Copyright:
© 2016, Springer International Publishing AG.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2016/12
Y1 - 2016/12
N2 - Preservatives serve the necessary purpose of preventing microbial contamination and maintaining cosmetic product integrity and safety; however, there are limitations to their use. Preservatives, including formaldehyde (FA) and formaldehyde releasers (FRPs), isothiazolinones, iodopropynyl butylcarbamate (IPBC), methyldibromoglutaronitrile (MDBGN), parabens, thimerosal, and triclosan, are a leading cause of allergic and irritant contact dermatitis, and there is increasing evidence that some may even cause toxic effects including endocrinological effects. One approach to minimizing these effects is the use of self-preserving or preservative-free cosmetic formulations. This article will outline these preservatives, their role in cosmetics, scientific evidence for allergy and toxic effects, and potential alternatives.
AB - Preservatives serve the necessary purpose of preventing microbial contamination and maintaining cosmetic product integrity and safety; however, there are limitations to their use. Preservatives, including formaldehyde (FA) and formaldehyde releasers (FRPs), isothiazolinones, iodopropynyl butylcarbamate (IPBC), methyldibromoglutaronitrile (MDBGN), parabens, thimerosal, and triclosan, are a leading cause of allergic and irritant contact dermatitis, and there is increasing evidence that some may even cause toxic effects including endocrinological effects. One approach to minimizing these effects is the use of self-preserving or preservative-free cosmetic formulations. This article will outline these preservatives, their role in cosmetics, scientific evidence for allergy and toxic effects, and potential alternatives.
KW - Contact dermatitis
KW - Cosmetics
KW - Endocrine effects
KW - Preservative free
KW - Preservatives
KW - Toxicity
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U2 - 10.1007/s40521-016-0102-4
DO - 10.1007/s40521-016-0102-4
M3 - Review article
AN - SCOPUS:85065753036
VL - 3
SP - 345
EP - 358
JO - Current Treatment Options in Allergy
JF - Current Treatment Options in Allergy
SN - 2196-3053
IS - 4
ER -