Preservation of immune function in cervical cancer patients during chemoradiation using a novel integrative approach

Susan K. Lutgendorf, Elizabeth Mullen-Houser, Daniel Russell, Koen DeGeest, Geraldine Jacobson, Laura Hart, David Bender, Barrie Anderson, Thomas E. Buekers, Michael J. Goodheart, Michael H Antoni, Anil K. Sood, David M. Lubaroff

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Patients receiving chemoradiation for cervical cancer are at risk for distress, chemoradiation-related side-effects, and immunosuppression. This prospective randomized clinical trial examined effects of a complementary therapy, Healing Touch (HT), versus relaxation training (RT) and usual care (UC) for (1) supporting cellular immunity, (2) improving mood and quality of life (QOL), and (3) reducing treatment-associated toxicities and treatment delay in cervical cancer patients receiving chemoradiation. Sixty women with stages IB1 to IVA cervical cancer were randomly assigned to receive UC or 4×/weekly individual sessions of either HT or RT immediately following radiation during their 6-week chemoradiation treatment. Patients completed psychosocial assessments and blood sampling before chemoradiation at baseline, weeks 4 and 6. Multilevel regression analyses using orthogonal contrasts tested for differences between treatment conditions over time. HT patients had a minimal decrease in natural killer cell cytotoxicity (NKCC) over the course of treatment whereas NKCC of RT and UC patients declined sharply during chemoradiation (group by time interaction: p=0.018). HT patients showed greater decreases in two different indicators of depressed mood (CES-D depressed mood subscale and POMS depression scale) compared to RT and UC (group by time interactions: p<0.05). No between group differences were observed in QOL, treatment delay, or clinically-rated toxicities. HT may benefit cervical cancer patients by moderating effects of chemoradiation on depressed mood and cellular immunity. Effects of HT on toxicities, treatment delay, QOL, and fatigue were not observed. Long-term clinical implications of findings are not known.

Original languageEnglish
Pages (from-to)1231-1240
Number of pages10
JournalBrain, Behavior, and Immunity
Volume24
Issue number8
DOIs
StatePublished - Nov 1 2010

Fingerprint

Uterine Cervical Neoplasms
Touch
Quality of Life
Cellular Immunity
Natural Killer Cells
Therapeutics
Multilevel Analysis
Complementary Therapies
Immunosuppression
Fatigue
Patient Care
Randomized Controlled Trials
Regression Analysis
Radiation
Depression

Keywords

  • Cervical cancer
  • Complementary and alternative medicine
  • Healing Touch
  • NK cell cytotoxicity
  • Psychoneuroimmunology
  • Relaxation

ASJC Scopus subject areas

  • Immunology
  • Behavioral Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Lutgendorf, S. K., Mullen-Houser, E., Russell, D., DeGeest, K., Jacobson, G., Hart, L., ... Lubaroff, D. M. (2010). Preservation of immune function in cervical cancer patients during chemoradiation using a novel integrative approach. Brain, Behavior, and Immunity, 24(8), 1231-1240. https://doi.org/10.1016/j.bbi.2010.06.014

Preservation of immune function in cervical cancer patients during chemoradiation using a novel integrative approach. / Lutgendorf, Susan K.; Mullen-Houser, Elizabeth; Russell, Daniel; DeGeest, Koen; Jacobson, Geraldine; Hart, Laura; Bender, David; Anderson, Barrie; Buekers, Thomas E.; Goodheart, Michael J.; Antoni, Michael H; Sood, Anil K.; Lubaroff, David M.

In: Brain, Behavior, and Immunity, Vol. 24, No. 8, 01.11.2010, p. 1231-1240.

Research output: Contribution to journalArticle

Lutgendorf, SK, Mullen-Houser, E, Russell, D, DeGeest, K, Jacobson, G, Hart, L, Bender, D, Anderson, B, Buekers, TE, Goodheart, MJ, Antoni, MH, Sood, AK & Lubaroff, DM 2010, 'Preservation of immune function in cervical cancer patients during chemoradiation using a novel integrative approach', Brain, Behavior, and Immunity, vol. 24, no. 8, pp. 1231-1240. https://doi.org/10.1016/j.bbi.2010.06.014
Lutgendorf, Susan K. ; Mullen-Houser, Elizabeth ; Russell, Daniel ; DeGeest, Koen ; Jacobson, Geraldine ; Hart, Laura ; Bender, David ; Anderson, Barrie ; Buekers, Thomas E. ; Goodheart, Michael J. ; Antoni, Michael H ; Sood, Anil K. ; Lubaroff, David M. / Preservation of immune function in cervical cancer patients during chemoradiation using a novel integrative approach. In: Brain, Behavior, and Immunity. 2010 ; Vol. 24, No. 8. pp. 1231-1240.
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