Preservation injury patterns in liver transplantation associated with poor prognosis

Y. M. Lee, Christopher B O'Brien, N. Yamashiki, M. Behro, D. Weppler, A. G. Tzakis, Eugene R Schiff

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Preservation injury (PI) is defined as hepatic dysfunction that occurs within 10 days of liver transplantation (OLT) but spontaneously resolves. However, we noted two new patterns: one characterized by histologic evidence of preservation injury that occurs at later than 10 days post-OLT (late PI), and a second, of persistent charge in liver biopsies > 10 days post-OLT (persistent PI). To characterize these new patterns, we performed a retrospective study of patients who underwent liver biopsies for hepatic dysfunction post-OLT from September 1993 to March 1998. The outcome of the 61 patients with preservation injury on liver biopsy after OLT was followed until the last clinic visit or death. Thirty patients had early PI, 16 patients had persistent preservation injury and 15 patients, late onset preservation injury. There were no significant differences in the age (P = .28), sex (P = .77), follow-up time (P = .78), cold ischemia (P = .3), or warm ischemia time (P = .16) between these groups. There was also no significant association between early preservation injury or persistent preservation injury with the development of acute or chronic rejection (P = .19). The overall survival rates at 1, 3, and 5 years was 52%, 45%, and 45%, respectively. There was no significant difference in survival between early, persistent, and late PI patterns (P = .59), although there was a trend toward better survival for patients with early preservation injury. The survival of OLT patients with persistent or late preservation injury is poor and should prompt consideration for retransplantation.

Original languageEnglish
Pages (from-to)2964-2966
Number of pages3
JournalTransplantation Proceedings
Volume35
Issue number8
DOIs
StatePublished - Dec 1 2003
Externally publishedYes

Fingerprint

Liver Transplantation
Wounds and Injuries
Liver
Biopsy
Survival
Cold Ischemia
Warm Ischemia
Ambulatory Care
Survival Rate
Retrospective Studies

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Preservation injury patterns in liver transplantation associated with poor prognosis. / Lee, Y. M.; O'Brien, Christopher B; Yamashiki, N.; Behro, M.; Weppler, D.; Tzakis, A. G.; Schiff, Eugene R.

In: Transplantation Proceedings, Vol. 35, No. 8, 01.12.2003, p. 2964-2966.

Research output: Contribution to journalArticle

Lee, Y. M. ; O'Brien, Christopher B ; Yamashiki, N. ; Behro, M. ; Weppler, D. ; Tzakis, A. G. ; Schiff, Eugene R. / Preservation injury patterns in liver transplantation associated with poor prognosis. In: Transplantation Proceedings. 2003 ; Vol. 35, No. 8. pp. 2964-2966.
@article{a41167a54c7443c1bae0d704feacdb56,
title = "Preservation injury patterns in liver transplantation associated with poor prognosis",
abstract = "Preservation injury (PI) is defined as hepatic dysfunction that occurs within 10 days of liver transplantation (OLT) but spontaneously resolves. However, we noted two new patterns: one characterized by histologic evidence of preservation injury that occurs at later than 10 days post-OLT (late PI), and a second, of persistent charge in liver biopsies > 10 days post-OLT (persistent PI). To characterize these new patterns, we performed a retrospective study of patients who underwent liver biopsies for hepatic dysfunction post-OLT from September 1993 to March 1998. The outcome of the 61 patients with preservation injury on liver biopsy after OLT was followed until the last clinic visit or death. Thirty patients had early PI, 16 patients had persistent preservation injury and 15 patients, late onset preservation injury. There were no significant differences in the age (P = .28), sex (P = .77), follow-up time (P = .78), cold ischemia (P = .3), or warm ischemia time (P = .16) between these groups. There was also no significant association between early preservation injury or persistent preservation injury with the development of acute or chronic rejection (P = .19). The overall survival rates at 1, 3, and 5 years was 52{\%}, 45{\%}, and 45{\%}, respectively. There was no significant difference in survival between early, persistent, and late PI patterns (P = .59), although there was a trend toward better survival for patients with early preservation injury. The survival of OLT patients with persistent or late preservation injury is poor and should prompt consideration for retransplantation.",
author = "Lee, {Y. M.} and O'Brien, {Christopher B} and N. Yamashiki and M. Behro and D. Weppler and Tzakis, {A. G.} and Schiff, {Eugene R}",
year = "2003",
month = "12",
day = "1",
doi = "10.1016/j.transproceed.2003.10.084",
language = "English",
volume = "35",
pages = "2964--2966",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier USA",
number = "8",

}

TY - JOUR

T1 - Preservation injury patterns in liver transplantation associated with poor prognosis

AU - Lee, Y. M.

AU - O'Brien, Christopher B

AU - Yamashiki, N.

AU - Behro, M.

AU - Weppler, D.

AU - Tzakis, A. G.

AU - Schiff, Eugene R

PY - 2003/12/1

Y1 - 2003/12/1

N2 - Preservation injury (PI) is defined as hepatic dysfunction that occurs within 10 days of liver transplantation (OLT) but spontaneously resolves. However, we noted two new patterns: one characterized by histologic evidence of preservation injury that occurs at later than 10 days post-OLT (late PI), and a second, of persistent charge in liver biopsies > 10 days post-OLT (persistent PI). To characterize these new patterns, we performed a retrospective study of patients who underwent liver biopsies for hepatic dysfunction post-OLT from September 1993 to March 1998. The outcome of the 61 patients with preservation injury on liver biopsy after OLT was followed until the last clinic visit or death. Thirty patients had early PI, 16 patients had persistent preservation injury and 15 patients, late onset preservation injury. There were no significant differences in the age (P = .28), sex (P = .77), follow-up time (P = .78), cold ischemia (P = .3), or warm ischemia time (P = .16) between these groups. There was also no significant association between early preservation injury or persistent preservation injury with the development of acute or chronic rejection (P = .19). The overall survival rates at 1, 3, and 5 years was 52%, 45%, and 45%, respectively. There was no significant difference in survival between early, persistent, and late PI patterns (P = .59), although there was a trend toward better survival for patients with early preservation injury. The survival of OLT patients with persistent or late preservation injury is poor and should prompt consideration for retransplantation.

AB - Preservation injury (PI) is defined as hepatic dysfunction that occurs within 10 days of liver transplantation (OLT) but spontaneously resolves. However, we noted two new patterns: one characterized by histologic evidence of preservation injury that occurs at later than 10 days post-OLT (late PI), and a second, of persistent charge in liver biopsies > 10 days post-OLT (persistent PI). To characterize these new patterns, we performed a retrospective study of patients who underwent liver biopsies for hepatic dysfunction post-OLT from September 1993 to March 1998. The outcome of the 61 patients with preservation injury on liver biopsy after OLT was followed until the last clinic visit or death. Thirty patients had early PI, 16 patients had persistent preservation injury and 15 patients, late onset preservation injury. There were no significant differences in the age (P = .28), sex (P = .77), follow-up time (P = .78), cold ischemia (P = .3), or warm ischemia time (P = .16) between these groups. There was also no significant association between early preservation injury or persistent preservation injury with the development of acute or chronic rejection (P = .19). The overall survival rates at 1, 3, and 5 years was 52%, 45%, and 45%, respectively. There was no significant difference in survival between early, persistent, and late PI patterns (P = .59), although there was a trend toward better survival for patients with early preservation injury. The survival of OLT patients with persistent or late preservation injury is poor and should prompt consideration for retransplantation.

UR - http://www.scopus.com/inward/record.url?scp=0345870145&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0345870145&partnerID=8YFLogxK

U2 - 10.1016/j.transproceed.2003.10.084

DO - 10.1016/j.transproceed.2003.10.084

M3 - Article

C2 - 14697950

AN - SCOPUS:0345870145

VL - 35

SP - 2964

EP - 2966

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 8

ER -