Multicentric Castleman's disease (MCD), or multicentric angiofollicular lymph node hyperplasia, is an uncommon lymphoproliferative disorder which typically presents with constitutional symptoms, multicentric lymphadenopathy, hepatosplenomegaly, effusions, and ascites. We describe a patient with several novel manifestations of MCD: sicca syndrome, lacrimal and salivary gland enlargement, cardiomyopathy, and palmar and plantar rash. Treatment of MCD with chlorambucil and prednisone was effective in the short term followup of this patient. MCD merits consideration in patients with lymphadenopathy and multisystem disease, including sicca syndrome, heart failure or rash.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Rheumatology|
|State||Published - Dec 1 1993|
- MULTICENTRIC CASTLEMAN'S DISEASE
- SICCA SYNDROME
ASJC Scopus subject areas