Presentation and outcome following radical cystectomy in hispanics with bladder cancer

Murugesan Manoharan, R. Ayyathurai, R. de Los Santos, A. M. Nieder, M. S. Soloway

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: Significant racial and ethnic differences in the epidemiology of bladder cancer (BC) exist. Studies have shown African Americans to have lower incidence ofbladder cancer than Caucasians, but higher incidence of invasive BC. Hispanics are the largest minority group in the United States. However, no reported studies on bladder cancer among Hispanics are available to date. As our center is in a unique position to study BC in Hispanic patients we were prompted to assess presentation and outcome of patients undergoing radical cystectomy (RC) for BC. Materials and Methods: Between January 1992 and May 2006, 448 RC were performed. All relevant data were collected and entered into a database. Patients were categorized by ethnicity as Hispanic and non-Hispanic White. African-American and other minority groups were excluded because of the small number. Comparative analysis of Hispanic and non-Hispanic White patients was performed. Results: 67 (17%) patients were Hispanic. Mean follow-up period was 41 (SD±40) months. Clinical and pathological data between these two groups were compared. Pre-cystectomy T stage was not significantly different botween both groups. However, after RC incidence of ≤T1 disease in Hispanics was lower (22%) than Caucasians (37%). This difference, statistically significant (P = 0.024) indicates that Hispanics who undergo RC present with higher stage disease. Kaplan-Meier log rank test indicated a difference in disease free survival and disease specific survival between the two groups but however it did not reach statistical significance (Log Rank P = 0.082, P = 0.063). No significant difference in overall survival was observed (P = 0.465). Conclusions: Hispanic patients managed with RC for bladder carcinoma present with higher stage disease.

Original languageEnglish
Pages (from-to)691-698
Number of pages8
JournalInternational Braz J Urol
Volume34
Issue number6
StatePublished - Dec 1 2008

Fingerprint

Cystectomy
Hispanic Americans
Urinary Bladder Neoplasms
Minority Groups
African Americans
Incidence
Survival
Disease-Free Survival
Epidemiology
Urinary Bladder
Databases
Carcinoma

Keywords

  • Bladder cancer
  • Cystectomy
  • Hispanic
  • Latino

ASJC Scopus subject areas

  • Urology

Cite this

Manoharan, M., Ayyathurai, R., de Los Santos, R., Nieder, A. M., & Soloway, M. S. (2008). Presentation and outcome following radical cystectomy in hispanics with bladder cancer. International Braz J Urol, 34(6), 691-698.

Presentation and outcome following radical cystectomy in hispanics with bladder cancer. / Manoharan, Murugesan; Ayyathurai, R.; de Los Santos, R.; Nieder, A. M.; Soloway, M. S.

In: International Braz J Urol, Vol. 34, No. 6, 01.12.2008, p. 691-698.

Research output: Contribution to journalArticle

Manoharan, M, Ayyathurai, R, de Los Santos, R, Nieder, AM & Soloway, MS 2008, 'Presentation and outcome following radical cystectomy in hispanics with bladder cancer', International Braz J Urol, vol. 34, no. 6, pp. 691-698.
Manoharan M, Ayyathurai R, de Los Santos R, Nieder AM, Soloway MS. Presentation and outcome following radical cystectomy in hispanics with bladder cancer. International Braz J Urol. 2008 Dec 1;34(6):691-698.
Manoharan, Murugesan ; Ayyathurai, R. ; de Los Santos, R. ; Nieder, A. M. ; Soloway, M. S. / Presentation and outcome following radical cystectomy in hispanics with bladder cancer. In: International Braz J Urol. 2008 ; Vol. 34, No. 6. pp. 691-698.
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