Presence of cellular retinol and retinoic acid-binding proteins in epidermoid carcinoma of the oral cavity and oropharynx

D. E. Ong, W. Jarrard Goodwin, R. H. Jesse, A. C. Griffin

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Epidermoid carcinomas of the oral cavity and oropharynx from six patients were examined for the presence and amount of cellular retinol (CRBP) and cellular retinoic acid-binding (CRABP) proteins. In all cases adjacent, grossly normal tissue was similarly examined. For each sample CRBP levels were significantly higher in tumor tissue compared to adjacent tissue. In four cases CRABP was significantly higher. This is of interest because retinol, retinoic acid and their analogs have been shown to inhibit the development of various epithelial tumors, and this inhibition is possibly mediated by these binding proteins.

Original languageEnglish
Pages (from-to)1409-1412
Number of pages4
JournalCancer
Volume49
Issue number7
StatePublished - Jan 1 1982
Externally publishedYes

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Retinoic Acid Receptors
Oropharynx
Vitamin A
Mouth
Squamous Cell Carcinoma
Tretinoin
Neoplasms
Carrier Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Presence of cellular retinol and retinoic acid-binding proteins in epidermoid carcinoma of the oral cavity and oropharynx. / Ong, D. E.; Goodwin, W. Jarrard; Jesse, R. H.; Griffin, A. C.

In: Cancer, Vol. 49, No. 7, 01.01.1982, p. 1409-1412.

Research output: Contribution to journalArticle

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