Abstract
Cycads, the most primitive of the living gymnosperms, have been used and continue to be used for food and medicinal purposes by many cultures, although toxins must be removed before ingestion. In our quest to identify tropical plants that contain inhibitors of the cytochrome P-450 aromatase and thus may be efficacious in treating estrogen-dependent tumors, we have screened extracts from 5 species of cycad folia encompassing 3 genera: Cycas cairnsiana F. Muell., Cycas revoluta Thunb., Cycas rumphii Miq., Dioon spinulosum Dyer and Encephalartos ferox Bertol. All extracts were found to contain inhibitors of the human enzyme.
| Original language | English |
|---|---|
| Pages (from-to) | 113-116 |
| Number of pages | 4 |
| Journal | Journal of Ethnopharmacology |
| Volume | 47 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 28 1995 |
Fingerprint
Keywords
- Aromatase inhibitor
- Cycads
- Enzyme inhibitor
ASJC Scopus subject areas
- Drug Discovery
- Pharmacology
Cite this
Presence of aromatase inhibitors in cycads. / Kowalska, Maria T.; Itzhak, Yossef; Puett, David.
In: Journal of Ethnopharmacology, Vol. 47, No. 3, 28.07.1995, p. 113-116.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Presence of aromatase inhibitors in cycads
AU - Kowalska, Maria T.
AU - Itzhak, Yossef
AU - Puett, David
PY - 1995/7/28
Y1 - 1995/7/28
N2 - Cycads, the most primitive of the living gymnosperms, have been used and continue to be used for food and medicinal purposes by many cultures, although toxins must be removed before ingestion. In our quest to identify tropical plants that contain inhibitors of the cytochrome P-450 aromatase and thus may be efficacious in treating estrogen-dependent tumors, we have screened extracts from 5 species of cycad folia encompassing 3 genera: Cycas cairnsiana F. Muell., Cycas revoluta Thunb., Cycas rumphii Miq., Dioon spinulosum Dyer and Encephalartos ferox Bertol. All extracts were found to contain inhibitors of the human enzyme.
AB - Cycads, the most primitive of the living gymnosperms, have been used and continue to be used for food and medicinal purposes by many cultures, although toxins must be removed before ingestion. In our quest to identify tropical plants that contain inhibitors of the cytochrome P-450 aromatase and thus may be efficacious in treating estrogen-dependent tumors, we have screened extracts from 5 species of cycad folia encompassing 3 genera: Cycas cairnsiana F. Muell., Cycas revoluta Thunb., Cycas rumphii Miq., Dioon spinulosum Dyer and Encephalartos ferox Bertol. All extracts were found to contain inhibitors of the human enzyme.
KW - Aromatase inhibitor
KW - Cycads
KW - Enzyme inhibitor
UR - http://www.scopus.com/inward/record.url?scp=0029039066&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029039066&partnerID=8YFLogxK
U2 - 10.1016/0378-8741(95)01259-G
DO - 10.1016/0378-8741(95)01259-G
M3 - Article
C2 - 8569233
AN - SCOPUS:0029039066
VL - 47
SP - 113
EP - 116
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
SN - 0378-8741
IS - 3
ER -