Presence of aromatase inhibitors in cycads

Maria T. Kowalska; Yossef Itzhak; David Puett

doi:10.1016/0378-8741(95)01259-G

Presence of aromatase inhibitors in cycads

Maria T. Kowalska, Yossef Itzhak, David Puett

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Cycads, the most primitive of the living gymnosperms, have been used and continue to be used for food and medicinal purposes by many cultures, although toxins must be removed before ingestion. In our quest to identify tropical plants that contain inhibitors of the cytochrome P-450 aromatase and thus may be efficacious in treating estrogen-dependent tumors, we have screened extracts from 5 species of cycad folia encompassing 3 genera: Cycas cairnsiana F. Muell., Cycas revoluta Thunb., Cycas rumphii Miq., Dioon spinulosum Dyer and Encephalartos ferox Bertol. All extracts were found to contain inhibitors of the human enzyme.

Original language	English (US)
Pages (from-to)	113-116
Number of pages	4
Journal	Journal of Ethnopharmacology
Volume	47
Issue number	3
DOIs	https://doi.org/10.1016/0378-8741(95)01259-G
State	Published - Jul 28 1995

Keywords

Aromatase inhibitor
Cycads
Enzyme inhibitor

ASJC Scopus subject areas

Drug Discovery
Pharmacology

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title = "Presence of aromatase inhibitors in cycads",

abstract = "Cycads, the most primitive of the living gymnosperms, have been used and continue to be used for food and medicinal purposes by many cultures, although toxins must be removed before ingestion. In our quest to identify tropical plants that contain inhibitors of the cytochrome P-450 aromatase and thus may be efficacious in treating estrogen-dependent tumors, we have screened extracts from 5 species of cycad folia encompassing 3 genera: Cycas cairnsiana F. Muell., Cycas revoluta Thunb., Cycas rumphii Miq., Dioon spinulosum Dyer and Encephalartos ferox Bertol. All extracts were found to contain inhibitors of the human enzyme.",

keywords = "Aromatase inhibitor, Cycads, Enzyme inhibitor",

author = "Kowalska, {Maria T.} and Yossef Itzhak and David Puett",

note = "Funding Information: It is a pleasure to thank Daniela Cristanta for expert technical assistance in the enzyme assays. We also gratefully acknowledge partial support provided by the University of Miami Sylvester Comprehensive Cancer Center.",

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T1 - Presence of aromatase inhibitors in cycads

AU - Kowalska, Maria T.

AU - Itzhak, Yossef

AU - Puett, David

N1 - Funding Information: It is a pleasure to thank Daniela Cristanta for expert technical assistance in the enzyme assays. We also gratefully acknowledge partial support provided by the University of Miami Sylvester Comprehensive Cancer Center.

PY - 1995/7/28

Y1 - 1995/7/28

N2 - Cycads, the most primitive of the living gymnosperms, have been used and continue to be used for food and medicinal purposes by many cultures, although toxins must be removed before ingestion. In our quest to identify tropical plants that contain inhibitors of the cytochrome P-450 aromatase and thus may be efficacious in treating estrogen-dependent tumors, we have screened extracts from 5 species of cycad folia encompassing 3 genera: Cycas cairnsiana F. Muell., Cycas revoluta Thunb., Cycas rumphii Miq., Dioon spinulosum Dyer and Encephalartos ferox Bertol. All extracts were found to contain inhibitors of the human enzyme.

AB - Cycads, the most primitive of the living gymnosperms, have been used and continue to be used for food and medicinal purposes by many cultures, although toxins must be removed before ingestion. In our quest to identify tropical plants that contain inhibitors of the cytochrome P-450 aromatase and thus may be efficacious in treating estrogen-dependent tumors, we have screened extracts from 5 species of cycad folia encompassing 3 genera: Cycas cairnsiana F. Muell., Cycas revoluta Thunb., Cycas rumphii Miq., Dioon spinulosum Dyer and Encephalartos ferox Bertol. All extracts were found to contain inhibitors of the human enzyme.

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KW - Cycads

KW - Enzyme inhibitor

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Presence of aromatase inhibitors in cycads

Abstract

Keywords

ASJC Scopus subject areas

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