TY - JOUR
T1 - Prescription opioids are associated with higher mortality in patients diagnosed with sepsis
T2 - A retrospective cohort study using electronic health records
AU - Zhang, Rui
AU - Meng, Jingjing
AU - Lian, Qinshu
AU - Chen, Xi
AU - Bauman, Brent
AU - Chu, Haitao
AU - Segura, Bradley
AU - Roy, Sabita
N1 - Funding Information:
The clinical data used in the present study was provided by the University of Minnesota’s Informatics Consulting Service. The research is supported in part by grant number UL1TR000114 from the National Center for Advancing Translational Sciences of the National Institutes of Health. Dr. Rui Zhang is supported by the grant from NIH 1R01AT009457. Dr. Sabita Roy received grants from NIH R01 DA043252, NIH R01 DA037843, NIH R01 DA034582, NIH R01DA044582, and NIH K05 DA033881. There was no additional external funding received for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
PY - 2018/1
Y1 - 2018/1
N2 - Sepsis continues to be a major problem for hospitalized patients. Opioids are widely used medications for pain management despite recent evidence revealing their adverse effects. The present study evaluates survival differences between opioid-treated patients and non-opioid-treated patients hospitalized with a diagnosis of sepsis. Clinical data was extracted from the University of Minnesota’s Clinical Data Repository, which includes Electronic Health Records (EHRs) of the patients seen at 8 hospitals. Among 5,994 patients diagnosed with sepsis, 4,540 opioid-treated patients and 1,454 non-opioid patients were included based on whether they are exposed to prescription opioids during their hospitalization. Cox proportional hazards regression showed that after adjustments for demographics, clinical comorbidities, severity of illness, and types of infection, opioid-treated patients had a significantly higher risk of death at 28 days.
AB - Sepsis continues to be a major problem for hospitalized patients. Opioids are widely used medications for pain management despite recent evidence revealing their adverse effects. The present study evaluates survival differences between opioid-treated patients and non-opioid-treated patients hospitalized with a diagnosis of sepsis. Clinical data was extracted from the University of Minnesota’s Clinical Data Repository, which includes Electronic Health Records (EHRs) of the patients seen at 8 hospitals. Among 5,994 patients diagnosed with sepsis, 4,540 opioid-treated patients and 1,454 non-opioid patients were included based on whether they are exposed to prescription opioids during their hospitalization. Cox proportional hazards regression showed that after adjustments for demographics, clinical comorbidities, severity of illness, and types of infection, opioid-treated patients had a significantly higher risk of death at 28 days.
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U2 - 10.1371/journal.pone.0190362
DO - 10.1371/journal.pone.0190362
M3 - Article
C2 - 29293575
AN - SCOPUS:85039935067
VL - 13
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 1
M1 - e0190362
ER -