Prescription opioids are associated with higher mortality in patients diagnosed with sepsis: A retrospective cohort study using electronic health records

Rui Zhang, Jingjing Meng, Qinshu Lian, Xi Chen, Brent Bauman, Haitao Chu, Bradley Segura, Sabita Roy

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Sepsis continues to be a major problem for hospitalized patients. Opioids are widely used medications for pain management despite recent evidence revealing their adverse effects. The present study evaluates survival differences between opioid-treated patients and non-opioid-treated patients hospitalized with a diagnosis of sepsis. Clinical data was extracted from the University of Minnesota’s Clinical Data Repository, which includes Electronic Health Records (EHRs) of the patients seen at 8 hospitals. Among 5,994 patients diagnosed with sepsis, 4,540 opioid-treated patients and 1,454 non-opioid patients were included based on whether they are exposed to prescription opioids during their hospitalization. Cox proportional hazards regression showed that after adjustments for demographics, clinical comorbidities, severity of illness, and types of infection, opioid-treated patients had a significantly higher risk of death at 28 days.

Original languageEnglish (US)
Article numbere0190362
JournalPLoS One
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

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sepsis (infection)
Electronic Health Records
narcotics
cohort studies
Opioid Analgesics
electronics
Prescriptions
Sepsis
Cohort Studies
Retrospective Studies
Health
Mortality
Hazards
Pain Management
drug therapy
Comorbidity
pain
Hospitalization
demographic statistics
adverse effects

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Prescription opioids are associated with higher mortality in patients diagnosed with sepsis : A retrospective cohort study using electronic health records. / Zhang, Rui; Meng, Jingjing; Lian, Qinshu; Chen, Xi; Bauman, Brent; Chu, Haitao; Segura, Bradley; Roy, Sabita.

In: PLoS One, Vol. 13, No. 1, e0190362, 01.01.2018.

Research output: Contribution to journalArticle

Zhang, Rui ; Meng, Jingjing ; Lian, Qinshu ; Chen, Xi ; Bauman, Brent ; Chu, Haitao ; Segura, Bradley ; Roy, Sabita. / Prescription opioids are associated with higher mortality in patients diagnosed with sepsis : A retrospective cohort study using electronic health records. In: PLoS One. 2018 ; Vol. 13, No. 1.
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