TY - JOUR
T1 - Prepartum, Postpartum, and Chronic Depression Effects on Newborns
AU - Diego, Miguel A.
AU - Field, Tiffany
AU - Hernandez-Reif, Maria
AU - Cullen, Christy
AU - Schanberg, Saul
AU - Kuhn, Cynthia
N1 - Funding Information:
Miguel A. Diego, MA, is affiliated with Touch Research Institutes, University of Miami School of Medicine, and Florida Atlantic University, Department of Psychology. Tiffany Field, PhD, Maria Hernandez-Reif, PhD, and Christie Cullen, BA, are affiliated with Touch Research Institutes, University of Miami School of Medicine. Saul Schanberg, PhD, and Cynthia Kuhn, PhD, are affiliated with Duke University Medical Center, Department of Pharmacology. We would like to thank the mother-infant dyads who participated in this study. This research was supported by an NIMH Research Scientist Award (#MH00331), an NIMH research Grant (#MH46586) to Tiffany Field, Ph.D., and funding from Johnson & Johnson. Address correspondence to Tiffany Field, Ph.D., Touch Research Institutes, University of Miami School of Medicine, P.O. Box 016820, Miami, Florida 33101; E-mail: tfield@med.miami.edu.
PY - 2004/3
Y1 - 2004/3
N2 - In order to assess the effects of the onset and chronicity of maternal depression on neonatal physiology, eighty pregnant women were assessed for depression during mid-pregnancy (M gestational age = 25.9 weeks) and shortly after delivery. The women were classified as reporting depressive symptoms 1) only during the prepartum assessment; 2) only during the postpartum assessment; 3) during both the prepartum and postpartum assessments; or 4) reporting no depressive symptoms at either the prepartum or the postpartum assessment. Maternal mood and biochemistry were assessed during pregnancy, and the EEG and biochemical characteristics of their 1-week-old infants were assessed shortly after birth. As predicted, the newborns of the mothers with prepartum and postpartum depressive symptoms had elevated cortisol and norepinephrine levels, lower dopamine levels, and greater relative right frontal EEG asymmetry. The infants in the prepartum group also showed greater relative right frontal EEG asymmetry and higher norepinephrine levels. These data suggest that effects on newborn physiology depend more on prepartum than postpartum maternal depression but may also depend on the duration of the depressive symptoms.
AB - In order to assess the effects of the onset and chronicity of maternal depression on neonatal physiology, eighty pregnant women were assessed for depression during mid-pregnancy (M gestational age = 25.9 weeks) and shortly after delivery. The women were classified as reporting depressive symptoms 1) only during the prepartum assessment; 2) only during the postpartum assessment; 3) during both the prepartum and postpartum assessments; or 4) reporting no depressive symptoms at either the prepartum or the postpartum assessment. Maternal mood and biochemistry were assessed during pregnancy, and the EEG and biochemical characteristics of their 1-week-old infants were assessed shortly after birth. As predicted, the newborns of the mothers with prepartum and postpartum depressive symptoms had elevated cortisol and norepinephrine levels, lower dopamine levels, and greater relative right frontal EEG asymmetry. The infants in the prepartum group also showed greater relative right frontal EEG asymmetry and higher norepinephrine levels. These data suggest that effects on newborn physiology depend more on prepartum than postpartum maternal depression but may also depend on the duration of the depressive symptoms.
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U2 - 10.1521/psyc.67.1.63.31251
DO - 10.1521/psyc.67.1.63.31251
M3 - Article
C2 - 15139586
AN - SCOPUS:1942476739
VL - 67
SP - 63
EP - 80
JO - Psychiatry
JF - Psychiatry
SN - 0033-2747
IS - 1
ER -