Preoperative versus postoperative radiation therapy for soft-tissue sarcomas.

Timothy R. Kuklo, H. Thomas Temple, Brett D. Owens, John Juliano, Richard B. Islinger, Yvonne Andejeski, Deborah A. Frassica, B. Hudson Berrey

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28 Scopus citations

Abstract

In this article, we report results from a retrospective consecutive series of 117 patients with soft-tissue sarcomas treated with adjuvant radiation and surgical resection at 2 associated institutions. Fifty-nine patients received preoperative radiation; 58 patients received postoperative radiation. Mean clinical follow-ups were 6.1 years and 8.4 years, respectively. Nineteen (32.2%) of 59 patients in the preoperative group and 17 (29.3%) of 58 patients in the postoperative group had wound complications (P = .89). Three (5.1%) of 59 sarcomas in the preoperative group and 7 (12.1%) of 58 sarcomas in the postoperative group recurred locally (P = .19). Improved local disease control and other potential advantages of using preoperative radiation make this a preferred adjuvant treatment.

Original languageEnglish (US)
Pages (from-to)75-80
Number of pages6
JournalAmerican journal of orthopedics (Belle Mead, N.J.)
Volume34
Issue number2
StatePublished - Feb 2005

ASJC Scopus subject areas

  • Medicine(all)

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    Kuklo, T. R., Temple, H. T., Owens, B. D., Juliano, J., Islinger, R. B., Andejeski, Y., Frassica, D. A., & Berrey, B. H. (2005). Preoperative versus postoperative radiation therapy for soft-tissue sarcomas. American journal of orthopedics (Belle Mead, N.J.), 34(2), 75-80.