Preoperative scintigraphy and operative probe scintimetry of colorectal carcinoma using technetium-99m-88BV59

Frederick L Moffat, R. D. Vargas-Cuba, Aldo N Serafini, A. M. Jabir, George N Sfakianakis, S. Y. Sittler, D. S. Robinson, V. Z. Crichton, R. Subramanian, J. H. Murray, J. L. Klein, M. G. Hanna, R. L. DeJager

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Abstract

We report a pilot study of radioimmunoscintigraphy (RIS) and operative gamma probe scintimetry (OPS) using a 99mTc-labeled anti-cytokeratin human monoclonal antibody (MAb) (99mTC-88BV59) in patients with newly diagnosed, recurrent or metastatic colorectal cancer. Methods: Twelve presurgical patients with biopsy- or contrast radiographic-proven colorectal cancer or recurrent colorectal carcinoma were studied. After chest roentgenography and abdominopelvic CT, 99mTc-88BV59 was administered intravenously, planar and SPECT external imaging was performed 3 to 6 hr after injection and planar imaging was performed 18 to 24 hr after injection. Surgery was performed immediately after late planar imaging. OPS of a standardized list of sites to document background radiation activity and of tumor sites, resection margins and tumor beds was performed. Results: The patients had 23 histologically proven tumor sites. Overall sensitivity for CT, planar RIS, SPECT, surgery and OPS was 43%, 61%, 78%, 96% and 91%, respectively. SPECT was superior to CT for imaging extrahepatic abdominal and pelvic disease. OPS detected all river and extrahepatic abdominal tumor sites and correctly predicted histological tumor-free margins and tumor beds in all cases. OPS did not identify tumor deposits that the surgeon could neither see nor feel. No patient demonstrated human anti-human immune responsiveness 1 and 3 mo after 99mTc-88BV59 infusion. Conclusion: Technetium-99m-88BV59 is a safe, effective radioimmunoconjugate for colorectal cancer imaging, with superior sensitivity as compared to CT.

Original languageEnglish
Pages (from-to)738-745
Number of pages8
JournalJournal of Nuclear Medicine
Volume36
Issue number5
StatePublished - Jan 1 1995

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Technetium
Radionuclide Imaging
Colorectal Neoplasms
Single-Photon Emission-Computed Tomography
Radioimmunodetection
Neoplasms
Immunoconjugates
Background Radiation
Injections
Keratins
Rivers
Radiography
Thorax
Monoclonal Antibodies
Biopsy

Keywords

  • colorectal carcinoma
  • gamma detection probe
  • human immunoconjugates
  • radioimmunoscintigraphy
  • scintimetry

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Moffat, F. L., Vargas-Cuba, R. D., Serafini, A. N., Jabir, A. M., Sfakianakis, G. N., Sittler, S. Y., ... DeJager, R. L. (1995). Preoperative scintigraphy and operative probe scintimetry of colorectal carcinoma using technetium-99m-88BV59. Journal of Nuclear Medicine, 36(5), 738-745.

Preoperative scintigraphy and operative probe scintimetry of colorectal carcinoma using technetium-99m-88BV59. / Moffat, Frederick L; Vargas-Cuba, R. D.; Serafini, Aldo N; Jabir, A. M.; Sfakianakis, George N; Sittler, S. Y.; Robinson, D. S.; Crichton, V. Z.; Subramanian, R.; Murray, J. H.; Klein, J. L.; Hanna, M. G.; DeJager, R. L.

In: Journal of Nuclear Medicine, Vol. 36, No. 5, 01.01.1995, p. 738-745.

Research output: Contribution to journalArticle

Moffat, FL, Vargas-Cuba, RD, Serafini, AN, Jabir, AM, Sfakianakis, GN, Sittler, SY, Robinson, DS, Crichton, VZ, Subramanian, R, Murray, JH, Klein, JL, Hanna, MG & DeJager, RL 1995, 'Preoperative scintigraphy and operative probe scintimetry of colorectal carcinoma using technetium-99m-88BV59', Journal of Nuclear Medicine, vol. 36, no. 5, pp. 738-745.
Moffat, Frederick L ; Vargas-Cuba, R. D. ; Serafini, Aldo N ; Jabir, A. M. ; Sfakianakis, George N ; Sittler, S. Y. ; Robinson, D. S. ; Crichton, V. Z. ; Subramanian, R. ; Murray, J. H. ; Klein, J. L. ; Hanna, M. G. ; DeJager, R. L. / Preoperative scintigraphy and operative probe scintimetry of colorectal carcinoma using technetium-99m-88BV59. In: Journal of Nuclear Medicine. 1995 ; Vol. 36, No. 5. pp. 738-745.
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abstract = "We report a pilot study of radioimmunoscintigraphy (RIS) and operative gamma probe scintimetry (OPS) using a 99mTc-labeled anti-cytokeratin human monoclonal antibody (MAb) (99mTC-88BV59) in patients with newly diagnosed, recurrent or metastatic colorectal cancer. Methods: Twelve presurgical patients with biopsy- or contrast radiographic-proven colorectal cancer or recurrent colorectal carcinoma were studied. After chest roentgenography and abdominopelvic CT, 99mTc-88BV59 was administered intravenously, planar and SPECT external imaging was performed 3 to 6 hr after injection and planar imaging was performed 18 to 24 hr after injection. Surgery was performed immediately after late planar imaging. OPS of a standardized list of sites to document background radiation activity and of tumor sites, resection margins and tumor beds was performed. Results: The patients had 23 histologically proven tumor sites. Overall sensitivity for CT, planar RIS, SPECT, surgery and OPS was 43{\%}, 61{\%}, 78{\%}, 96{\%} and 91{\%}, respectively. SPECT was superior to CT for imaging extrahepatic abdominal and pelvic disease. OPS detected all river and extrahepatic abdominal tumor sites and correctly predicted histological tumor-free margins and tumor beds in all cases. OPS did not identify tumor deposits that the surgeon could neither see nor feel. No patient demonstrated human anti-human immune responsiveness 1 and 3 mo after 99mTc-88BV59 infusion. Conclusion: Technetium-99m-88BV59 is a safe, effective radioimmunoconjugate for colorectal cancer imaging, with superior sensitivity as compared to CT.",
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AU - Vargas-Cuba, R. D.

AU - Serafini, Aldo N

AU - Jabir, A. M.

AU - Sfakianakis, George N

AU - Sittler, S. Y.

AU - Robinson, D. S.

AU - Crichton, V. Z.

AU - Subramanian, R.

AU - Murray, J. H.

AU - Klein, J. L.

AU - Hanna, M. G.

AU - DeJager, R. L.

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N2 - We report a pilot study of radioimmunoscintigraphy (RIS) and operative gamma probe scintimetry (OPS) using a 99mTc-labeled anti-cytokeratin human monoclonal antibody (MAb) (99mTC-88BV59) in patients with newly diagnosed, recurrent or metastatic colorectal cancer. Methods: Twelve presurgical patients with biopsy- or contrast radiographic-proven colorectal cancer or recurrent colorectal carcinoma were studied. After chest roentgenography and abdominopelvic CT, 99mTc-88BV59 was administered intravenously, planar and SPECT external imaging was performed 3 to 6 hr after injection and planar imaging was performed 18 to 24 hr after injection. Surgery was performed immediately after late planar imaging. OPS of a standardized list of sites to document background radiation activity and of tumor sites, resection margins and tumor beds was performed. Results: The patients had 23 histologically proven tumor sites. Overall sensitivity for CT, planar RIS, SPECT, surgery and OPS was 43%, 61%, 78%, 96% and 91%, respectively. SPECT was superior to CT for imaging extrahepatic abdominal and pelvic disease. OPS detected all river and extrahepatic abdominal tumor sites and correctly predicted histological tumor-free margins and tumor beds in all cases. OPS did not identify tumor deposits that the surgeon could neither see nor feel. No patient demonstrated human anti-human immune responsiveness 1 and 3 mo after 99mTc-88BV59 infusion. Conclusion: Technetium-99m-88BV59 is a safe, effective radioimmunoconjugate for colorectal cancer imaging, with superior sensitivity as compared to CT.

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