Preoperative scintigraphy and operative probe scintimetry of colorectal carcinoma using technetium-99m-88BV59

F. L. Moffat, R. D. Vargas-Cuba, A. N. Serafini, A. M. Jabir, G. N. Sfakianakis, S. Y. Sittler, D. S. Robinson, V. Z. Crichton, R. Subramanian, J. H. Murray, J. L. Klein, M. G. Hanna, R. L. DeJager

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

We report a pilot study of radioimmunoscintigraphy (RIS) and operative gamma probe scintimetry (OPS) using a 99mTc-labeled anti-cytokeratin human monoclonal antibody (MAb) (99mTC-88BV59) in patients with newly diagnosed, recurrent or metastatic colorectal cancer. Methods: Twelve presurgical patients with biopsy- or contrast radiographic-proven colorectal cancer or recurrent colorectal carcinoma were studied. After chest roentgenography and abdominopelvic CT, 99mTc-88BV59 was administered intravenously, planar and SPECT external imaging was performed 3 to 6 hr after injection and planar imaging was performed 18 to 24 hr after injection. Surgery was performed immediately after late planar imaging. OPS of a standardized list of sites to document background radiation activity and of tumor sites, resection margins and tumor beds was performed. Results: The patients had 23 histologically proven tumor sites. Overall sensitivity for CT, planar RIS, SPECT, surgery and OPS was 43%, 61%, 78%, 96% and 91%, respectively. SPECT was superior to CT for imaging extrahepatic abdominal and pelvic disease. OPS detected all river and extrahepatic abdominal tumor sites and correctly predicted histological tumor-free margins and tumor beds in all cases. OPS did not identify tumor deposits that the surgeon could neither see nor feel. No patient demonstrated human anti-human immune responsiveness 1 and 3 mo after 99mTc-88BV59 infusion. Conclusion: Technetium-99m-88BV59 is a safe, effective radioimmunoconjugate for colorectal cancer imaging, with superior sensitivity as compared to CT.

Original languageEnglish (US)
Pages (from-to)738-745
Number of pages8
JournalJournal of Nuclear Medicine
Volume36
Issue number5
StatePublished - Jan 1 1995

Keywords

  • colorectal carcinoma
  • gamma detection probe
  • human immunoconjugates
  • radioimmunoscintigraphy
  • scintimetry

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

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    Moffat, F. L., Vargas-Cuba, R. D., Serafini, A. N., Jabir, A. M., Sfakianakis, G. N., Sittler, S. Y., Robinson, D. S., Crichton, V. Z., Subramanian, R., Murray, J. H., Klein, J. L., Hanna, M. G., & DeJager, R. L. (1995). Preoperative scintigraphy and operative probe scintimetry of colorectal carcinoma using technetium-99m-88BV59. Journal of Nuclear Medicine, 36(5), 738-745.