Prenatal diagnosis of resistance to thyroid hormone and its clinical implications

Theodora Pappa, João Anselmo, Sunnee Mamanasiri, Alexandra M. Dumitrescu, Roy E. Weiss, Samuel Refetoff

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Context: Resistance to thyroid hormone-b (RTH-b) is an autosomal dominant disorder characterized by reduced sensitivity of target tissues to thyroid hormones (THs). Individuals with RTH-b have high TH levels usually due to mutations in the TH receptor-b (THRB) gene. The management of RTH-b during pregnancy is challenging, as wild-type (WT) fetuses born to RTH-b mothers have low birth weight and suppressed postnatal thyroid-stimulating hormone (TSH), due to intrauterine exposure to excess TH. Objective: To determine birth weight and postnatal TSH of WT fetuses carried by mothers with RTH-b whose fT4 levels were maintained below 20% of the upper limit of normal (ULN). Design: Retrospective chart review. Setting: Academic institution in collaboration with off-site hospitals and private practices. Patients: Thirteen women harboring THRB gene mutations were evaluated during 18 pregnancies. Intervention: Prenatal genetic diagnosis by amniocentesis. Women carrying WT fetuses were given the option of treatment with antithyroid medication by their treating physicians with the aim to avoid serum fT4 levels above 20% of the ULN. Results: No significant difference was found in birth weight corrected for gestational age and in serum TSH levels at birth between WT and RTH-b infants born to RTH-b mothers. Conclusions: Prenatal diagnosis may play an important role in the management of RTH-b during pregnancy. Aiming for maternal fT4 levels not above 50% of the ULN in RTH-b mothers carrying WT fetuses seems to be a prudent approach that prevents the otherwise expected low birth weight and postnatal TSH suppression. (J Clin Endocrinol Metab 102: 3775-3782, 2017).

Original languageEnglish (US)
Pages (from-to)3775-3782
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume102
Issue number10
DOIs
StatePublished - Oct 2017

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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