Prenatal cocaine exposure and childhood obesity at nine years

Linda L. LaGasse, Ronnesia B. Gaskins, Henrietta S. Bada, Seetha Shankaran, Jing Liu, Barry M. Lester, Charles R Bauer, Rosemary D. Higgins, Abhik Das, Mary Roberts

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Little is known about the association between prenatal cocaine exposure and obesity. We tested whether prenatal cocaine exposure increases the likelihood of obesity in 561 9-year-old term children from the Maternal Lifestyle Study (MLS). Overall, 21.6% of children met criterion for obesity (body mass index [BMI]. ≥ 95th percentile, age and sex-specific). While there was no overall cocaine effect on obesity, multivariate logistic analysis revealed that children exposed to cocaine but not alcohol were 4 times more likely to be obese (OR 4.11, CI 2.04-9.76) than children not exposed to either drug. No increase in obesity prevalence was found in children exposed to alcohol but not cocaine (OR 1.08, CI 59-1.93) or both (OR 1.21, CI 0.66-2.22). Alcohol exposure may attenuate the effect of cocaine exposure on obesity. Increased obesity associated with cocaine but not alcohol exposure was first observed at 7. years. BMI was also elevated from 3 to 9. years in children exposed to cocaine but not alcohol, due to increasing weight but normal height. Prenatal exposure to cocaine may alter the neuroendocrine system and metabolic processes resulting in increased weight gain and childhood obesity.

Original languageEnglish
Pages (from-to)188-197
Number of pages10
JournalNeurotoxicology and Teratology
Volume33
Issue number2
DOIs
StatePublished - Mar 1 2011

Fingerprint

Pediatric Obesity
Cocaine
Obesity
Alcohols
Body Mass Index
Neurosecretory Systems
Weight Gain
Logistics
Life Style
Multivariate Analysis
Mothers
Weights and Measures

Keywords

  • Childhood obesity
  • Fetal origins
  • Growth
  • Prenatal alcohol exposure
  • Prenatal cocaine exposure

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience
  • Toxicology

Cite this

LaGasse, L. L., Gaskins, R. B., Bada, H. S., Shankaran, S., Liu, J., Lester, B. M., ... Roberts, M. (2011). Prenatal cocaine exposure and childhood obesity at nine years. Neurotoxicology and Teratology, 33(2), 188-197. https://doi.org/10.1016/j.ntt.2010.11.002

Prenatal cocaine exposure and childhood obesity at nine years. / LaGasse, Linda L.; Gaskins, Ronnesia B.; Bada, Henrietta S.; Shankaran, Seetha; Liu, Jing; Lester, Barry M.; Bauer, Charles R; Higgins, Rosemary D.; Das, Abhik; Roberts, Mary.

In: Neurotoxicology and Teratology, Vol. 33, No. 2, 01.03.2011, p. 188-197.

Research output: Contribution to journalArticle

LaGasse, LL, Gaskins, RB, Bada, HS, Shankaran, S, Liu, J, Lester, BM, Bauer, CR, Higgins, RD, Das, A & Roberts, M 2011, 'Prenatal cocaine exposure and childhood obesity at nine years', Neurotoxicology and Teratology, vol. 33, no. 2, pp. 188-197. https://doi.org/10.1016/j.ntt.2010.11.002
LaGasse LL, Gaskins RB, Bada HS, Shankaran S, Liu J, Lester BM et al. Prenatal cocaine exposure and childhood obesity at nine years. Neurotoxicology and Teratology. 2011 Mar 1;33(2):188-197. https://doi.org/10.1016/j.ntt.2010.11.002
LaGasse, Linda L. ; Gaskins, Ronnesia B. ; Bada, Henrietta S. ; Shankaran, Seetha ; Liu, Jing ; Lester, Barry M. ; Bauer, Charles R ; Higgins, Rosemary D. ; Das, Abhik ; Roberts, Mary. / Prenatal cocaine exposure and childhood obesity at nine years. In: Neurotoxicology and Teratology. 2011 ; Vol. 33, No. 2. pp. 188-197.
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