Premorbid intellectual functioning and risk of schizophrenia and spectrum disorders

Abraham Reichenberg, Mark Weiser, Asaf Caspi, Haim Y. Knobler, Gad Lubin, Philip D. Harvey, Jonathan Rabinowitz, Michael Davidson

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


Evidence from longitudinal studies indicates that lower IQ score in childhood and early adolescence increases risk of schizophrenia and schizophrenia spectrum disorders (SSD). This study investigated the association between premorbid IQ and risk of SSD in a population-based cohort of 17-year-old conscripts. Fifty four thousand males assessed by the Israeli Draft Board during two consecutive years were followed by means of the Israeli National Psychiatric Hospitalization Case Registry for up to II years. Tests of verbal and non-verbal reasoning, mathematical knowledge and instructions comprehension and several psychosocial variables were recorded by the Draft Board. Risk for SSD increased with decreasing IQ score. Only poorer non-verbal reasoning conferred a significant increased risk for SSD after taking into account general intellectual ability. IQ was not associated with age of onset. These results confirm the importance of low intellectual functioning as a risk factor for SSD. This is unlikely to be due to prodrome.

Original languageEnglish (US)
Pages (from-to)193-207
Number of pages15
JournalJournal of Clinical and Experimental Neuropsychology
Issue number2
StatePublished - Feb 2006
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Psychology
  • Neurology
  • Clinical Neurology


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