Premature termination of hair follicle morphogenesis and accelarated hair follicle cycling in Iasi congenital atrichia (fzica) mice points to fuzzy as a key element of hair cycle control

Lars Mecklenburg, Desmond J. Tobin, Marius V. Cirlan, Constantin Craciun, Ralf Paus

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Inbred laboratory mice have proven to be useful model systems for studying hair biology and pathomechanisms of hair loss. Fuzzy (fz) is an autosomal recessive mutation that results in hair coat abnormalities. Though this mutant has long been known, its cutaneous abnormalities still await systematic analysis. Here, we provide a systematic skin phenotype analysis of mice that are homozygous for Iasi congenital atrichia (fzica/fzica), which is allelic to fz. Homozygous mice exhibit a sparse hair coat after birth and completely loose their hair at around postnatal day 120. Although early and mid stages of hair follicle morphogenesis are normal, late hair follicle morphogenesis reveals multifocal cell degeneration within the Huxley layer of the inner root sheath (IRS) and a complete lack of the hair shaft medulla. In addition, hair follicle development is prematurely terminated by induction of the first postnatal hair cycle with premature entry into catagen. Subsequently, a dramatically shortened telogen is immediately followed by premature anagen development, resulting in a marked, generalized acceleration of hair follicle cycling. This suggests that fuzzy is not only involved in structural hair shaft integrity and differentiation of the IRS and medulla, but also plays an important role in the control of hair follicle cycling. Our data show that fuzzy is involved in controlling both catagen and anagen initiation, designating fuzzy an exciting target for characterizing the intracutaneous oscillator system that drives hair follicle cycling.

Original languageEnglish (US)
Pages (from-to)561-570
Number of pages10
JournalExperimental dermatology
Volume14
Issue number8
DOIs
StatePublished - Aug 2005

Keywords

  • Catagen
  • Hair loss
  • Hair shaft
  • Inner root sheath
  • Telogen

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

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