Premature B-cell senescence as a consequence of chronic immune activation: Implications for vaccination of immune compromised individuals

Paolo Palma, Stefano Rinaldi, Nicola Cotugno, Veronica Santilli, Savita G Pahwa, Paolo Rossi, Alberto Cagigi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Similar features between the immune system of healthy elderly people and of younger individuals subjected to conditions of chronic immune activation are progressively being observed. This is raising the hypothesis that chronic immune activation may cause the premature aging of the immune system. Here we dissect this theory by comparing changes occurring to B-cells during healthy aging to the ones occurring during chronic immune activation in younger individuals. Moreover, we discuss how these changes may affect or predict response to vaccination in immune compromised individuals.

Original languageEnglish
Pages (from-to)2083-2088
Number of pages6
JournalHuman Vaccines and Immunotherapeutics
Volume10
Issue number7
DOIs
StatePublished - Jul 1 2014

Fingerprint

Cell Aging
Immune System
Vaccination
B-Lymphocytes
Premature Aging

Keywords

  • Activation-induced deaminase (AID)
  • Aging
  • Double negative B-cells
  • Immunization
  • Immunosenescence
  • Inflammaging
  • Mature-activated B-cells
  • Predictive biomarkers

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cite this

Premature B-cell senescence as a consequence of chronic immune activation : Implications for vaccination of immune compromised individuals. / Palma, Paolo; Rinaldi, Stefano; Cotugno, Nicola; Santilli, Veronica; Pahwa, Savita G; Rossi, Paolo; Cagigi, Alberto.

In: Human Vaccines and Immunotherapeutics, Vol. 10, No. 7, 01.07.2014, p. 2083-2088.

Research output: Contribution to journalArticle

Palma, Paolo ; Rinaldi, Stefano ; Cotugno, Nicola ; Santilli, Veronica ; Pahwa, Savita G ; Rossi, Paolo ; Cagigi, Alberto. / Premature B-cell senescence as a consequence of chronic immune activation : Implications for vaccination of immune compromised individuals. In: Human Vaccines and Immunotherapeutics. 2014 ; Vol. 10, No. 7. pp. 2083-2088.
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