Preliminary evaluation of a cervical self-sampling device with liquid-based cytology and multiparameter molecular testing

Bradley W. Knesel, Joel C. Dry, Coridalia Wald-Scott, Asma Aftoh

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


OBJECTIVE: To compare the collection of a liquid-based cell sample using a cervical self-sampling device and traditional sampling using cytologic and molecular-based tests. STUDY DESIGN: This study evaluated the sampling efficiency of the Fournier Cervical Self-Sampling Device (BPG, LLC, Miami, Florida) with regard to overall cell volume of the sample, cytologic diagnoses (SurePath, TriPath Imaging, Burlington, North Carolina) and molecular-based tests for Chlamydia, Gonorrhoeae and human papillomavirus (Hybrid Capture 2, Digene Corp., Gaithersburg, Maryland). Paired samples were blinded and prepared using the SurePath method. RESULTS: The self-collected samples showed an overall increase in cellularity when compared to the cellularity of samples obtained from traditional sampling. Cytologic results were comparable for the 2 sampling methods. The self-sampling device showed greater sensitivity with regard to molecular-based human papillomavirus testing. CONCLUSION: The Fournier Device shows promise in the area of cytology and molecular diagnostics. The ability to perform cytology and molecular-based assays using a single sample obtained directly by the patient can lower the costs of screening and provide an efficient method of screening women in resource-poor countries or when cultural barriers exist to the use of traditional sampling methods.

Original languageEnglish (US)
Pages (from-to)256-260
Number of pages5
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number4
StatePublished - Apr 1 2005


  • Cervical cancer
  • Cervical self-sampling
  • Cervix neoplasms
  • Liquid-based cytology

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine


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