Preksha Dhyāna meditation induces alterations at the transcriptome level in novice and healthy college students

Bassam Abomoelak, Samani U. Pragya, Anthony J. Griswold, Neelam Mehta, Parvin Uddin, Pushya Veeramachaneni, Naina Mehta, Samani C. Pragya, Hesham A. El Enshasy, Devendra Mehta

Research output: Contribution to journalArticlepeer-review


Background: The human transcriptome across a variety of cell types and tissues are affected by stress and other psychological factors. Preksha Dhyana meditation (PM) is effective at improving cognitive skills in novice healthy college student meditators after 8 weeks of intervention, but the molecular and cellular mechanisms involved in these improvements are still largely unknown. Methods: In order to decipher potential mechanisms at the cellular level, transcriptomic profiling analyses, from peripheral blood, were performed at baseline and 8 weeks post-intervention in 18-paired participants (RNASeq). Results: At the transcriptomic level, 494 genes were nominally differentially expressed (p-value ≤ 0.05) between baseline and 8 weeks post-intervention. Our data showed that 136 genes were upregulated, while 358 genes were downregulated. These genes were enriched in several cellular pathways including innate and adaptive immunity, cell signaling, and other metabolic processes. Conclusions: Overall, our findings indicate that PM meditation affects gene expression patterns from whole blood in novice healthy college students. Improvements at the cognitive skills were also mirrored with changes at RNA expression profiling.

Original languageEnglish (US)
JournalSaudi Journal of Biological Sciences
StateAccepted/In press - 2021


  • Cellular pathways
  • Preksha Dhyana
  • Transcriptome
  • Up-and down-regulated genes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)


Dive into the research topics of 'Preksha Dhyāna meditation induces alterations at the transcriptome level in novice and healthy college students'. Together they form a unique fingerprint.

Cite this