Prekeratin immunohistochemistry in the diagnosis of undifferentiated carcinoma of the nasopharyngeal type

J. Ziegels-Weissman, Mehrdad Nadji, N. S. Penneys, Azorides R Morales

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17 Citations (Scopus)

Abstract

We investigated the value of prekeratin immunostaining in establishing the diagnosis of undifferentiated carcinoma of the nasopharyngeal type (lymphoepithelioma). As in squamous cell carcinoma of the nasopharynx, all seven lymphoepithelial carcinomas stained for prekeratin whereas other look-alike but histogenetically different neoplasms (malignant lymphoma, esthesioneuroblastoma, and small round cell sarcomas) did not stain. In addition to confirming the squamous epithelial nature of lymphoepithelioma, our findings indicated that immunoperoxidase staining for prekeratin is a useful diagnostic tool in the differential diagnosis of nasopharyngeal carcinoma in general and lymphoepithelioma in particular.

Original languageEnglish
Pages (from-to)588-589
Number of pages2
JournalArchives of Pathology and Laboratory Medicine
Volume108
Issue number7
StatePublished - Jan 1 1984

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Immunohistochemistry
Carcinoma
Small Cell Sarcoma
Olfactory Esthesioneuroblastoma
Nasopharynx
Squamous Cell Carcinoma
Lymphoma
Differential Diagnosis
Coloring Agents
Staining and Labeling
prekeratin
Neoplasms
Nasopharyngeal carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Prekeratin immunohistochemistry in the diagnosis of undifferentiated carcinoma of the nasopharyngeal type. / Ziegels-Weissman, J.; Nadji, Mehrdad; Penneys, N. S.; Morales, Azorides R.

In: Archives of Pathology and Laboratory Medicine, Vol. 108, No. 7, 01.01.1984, p. 588-589.

Research output: Contribution to journalArticle

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