Prekeratin immunohistochemistry in the diagnosis of undifferentiated carcinoma of the nasopharyngeal type

J. Ziegels-Weissman, M. Nadji, N. S. Penneys, A. R. Morales

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

We investigated the value of prekeratin immunostaining in establishing the diagnosis of undifferentiated carcinoma of the nasopharyngeal type (lymphoepithelioma). As in squamous cell carcinoma of the nasopharynx, all seven lymphoepithelial carcinomas stained for prekeratin whereas other look-alike but histogenetically different neoplasms (malignant lymphoma, esthesioneuroblastoma, and small round cell sarcomas) did not stain. In addition to confirming the squamous epithelial nature of lymphoepithelioma, our findings indicated that immunoperoxidase staining for prekeratin is a useful diagnostic tool in the differential diagnosis of nasopharyngeal carcinoma in general and lymphoepithelioma in particular.

Original languageEnglish (US)
Pages (from-to)588-589
Number of pages2
JournalArchives of Pathology and Laboratory Medicine
Volume108
Issue number7
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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