Preimplantation genetic diagnosis: An overview of socio-ethical and legal considerations

Bartha M. Knoppers, Sylvie Bordet, Rosario M. Isasi

Research output: Chapter in Book/Report/Conference proceedingChapter

42 Scopus citations

Abstract

Preimplantation genetic diagnosis (PGD) permits the selection of embryos of a particular genotype prior to implantation. As a reproductive technology involving embryo selection, PGD has become associated with considerable controversy. This review examines some of the ethical, legal, and social issues raised by PGD. Relevant ethical considerations include the status of the embryo and the interests and duties of the parents. On a social policy level, considerations of access as well as the impact of this technology on families, women, and physician's duties also warrant consideration. An analysis of these issues in the context of using PGD for selecting embryos unaffected by a serious disorder and for sex selection is presented. We also present a brief survey of PGD-related regulatory schemes in several countries, including the United Kingdom and the United States.

Original languageEnglish (US)
Title of host publicationAnnual Review of Genomics and Human Genetics
EditorsAravinda Chakravarti, Eric Green
Pages201-221
Number of pages21
DOIs
StatePublished - Oct 31 2006
Externally publishedYes

Publication series

NameAnnual Review of Genomics and Human Genetics
Volume7
ISSN (Print)1527-8204

Keywords

  • ELSI
  • Ethics
  • Policy
  • Regulation

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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    Knoppers, B. M., Bordet, S., & Isasi, R. M. (2006). Preimplantation genetic diagnosis: An overview of socio-ethical and legal considerations. In A. Chakravarti, & E. Green (Eds.), Annual Review of Genomics and Human Genetics (pp. 201-221). (Annual Review of Genomics and Human Genetics; Vol. 7). https://doi.org/10.1146/annurev.genom.7.080505.115753