Pregnancy anxiety and comorbid depression and anger

Effects on the fetus and neonate

Tiffany M Field, Miguel A Diego, Maria Hernandez-Reif, Saul Schanberg, Cynthia Kuhn, Regina Yando, Debra Bendell

Research output: Contribution to journalArticle

203 Citations (Scopus)

Abstract

One hundred sixty-six women were classified as experiencing high or low anxiety during the second trimester of pregnancy. The high anxiety women also had high scores on depression and anger scales. In a follow-up across pregnancy, the fetuses of the high anxiety women were noted to be more active and to experience growth delays. The high anxiety mothers' high prenatal norepinephrine and low dopamine levels were followed by their neonates having low dopamine and serotonin levels. The high anxiety mothers' newborns also had greater relative right frontal EEG activation and lower vagal tone. Finally, the newborns of high anxiety mothers spent more time in deep sleep and less time in quiet and active alert states and showed more state changes and less optimal performance on the Brazelton Neonatal Behavior Assessment Scale (motor maturity, autonomic stability and withdrawal). These data highlight the need for prenatal intervention for elevated anxiety symptoms during pregnancy.

Original languageEnglish
Pages (from-to)140-151
Number of pages12
JournalDepression and Anxiety
Volume17
Issue number3
DOIs
StatePublished - Jun 11 2003

Fingerprint

Anger
Fetus
Anxiety
Newborn Infant
Depression
Pregnancy
Mothers
Dopamine
Second Pregnancy Trimester
Electroencephalography
Serotonin
Norepinephrine
Sleep
Growth

Keywords

  • Anger
  • Anxiety
  • Depression
  • Fetus
  • Newborn

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)
  • Clinical Psychology

Cite this

Pregnancy anxiety and comorbid depression and anger : Effects on the fetus and neonate. / Field, Tiffany M; Diego, Miguel A; Hernandez-Reif, Maria; Schanberg, Saul; Kuhn, Cynthia; Yando, Regina; Bendell, Debra.

In: Depression and Anxiety, Vol. 17, No. 3, 11.06.2003, p. 140-151.

Research output: Contribution to journalArticle

Field, TM, Diego, MA, Hernandez-Reif, M, Schanberg, S, Kuhn, C, Yando, R & Bendell, D 2003, 'Pregnancy anxiety and comorbid depression and anger: Effects on the fetus and neonate', Depression and Anxiety, vol. 17, no. 3, pp. 140-151. https://doi.org/10.1002/da.10071
Field, Tiffany M ; Diego, Miguel A ; Hernandez-Reif, Maria ; Schanberg, Saul ; Kuhn, Cynthia ; Yando, Regina ; Bendell, Debra. / Pregnancy anxiety and comorbid depression and anger : Effects on the fetus and neonate. In: Depression and Anxiety. 2003 ; Vol. 17, No. 3. pp. 140-151.
@article{4062149808a64995a694ee70b386384b,
title = "Pregnancy anxiety and comorbid depression and anger: Effects on the fetus and neonate",
abstract = "One hundred sixty-six women were classified as experiencing high or low anxiety during the second trimester of pregnancy. The high anxiety women also had high scores on depression and anger scales. In a follow-up across pregnancy, the fetuses of the high anxiety women were noted to be more active and to experience growth delays. The high anxiety mothers' high prenatal norepinephrine and low dopamine levels were followed by their neonates having low dopamine and serotonin levels. The high anxiety mothers' newborns also had greater relative right frontal EEG activation and lower vagal tone. Finally, the newborns of high anxiety mothers spent more time in deep sleep and less time in quiet and active alert states and showed more state changes and less optimal performance on the Brazelton Neonatal Behavior Assessment Scale (motor maturity, autonomic stability and withdrawal). These data highlight the need for prenatal intervention for elevated anxiety symptoms during pregnancy.",
keywords = "Anger, Anxiety, Depression, Fetus, Newborn",
author = "Field, {Tiffany M} and Diego, {Miguel A} and Maria Hernandez-Reif and Saul Schanberg and Cynthia Kuhn and Regina Yando and Debra Bendell",
year = "2003",
month = "6",
day = "11",
doi = "10.1002/da.10071",
language = "English",
volume = "17",
pages = "140--151",
journal = "Depression and Anxiety",
issn = "1091-4269",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Pregnancy anxiety and comorbid depression and anger

T2 - Effects on the fetus and neonate

AU - Field, Tiffany M

AU - Diego, Miguel A

AU - Hernandez-Reif, Maria

AU - Schanberg, Saul

AU - Kuhn, Cynthia

AU - Yando, Regina

AU - Bendell, Debra

PY - 2003/6/11

Y1 - 2003/6/11

N2 - One hundred sixty-six women were classified as experiencing high or low anxiety during the second trimester of pregnancy. The high anxiety women also had high scores on depression and anger scales. In a follow-up across pregnancy, the fetuses of the high anxiety women were noted to be more active and to experience growth delays. The high anxiety mothers' high prenatal norepinephrine and low dopamine levels were followed by their neonates having low dopamine and serotonin levels. The high anxiety mothers' newborns also had greater relative right frontal EEG activation and lower vagal tone. Finally, the newborns of high anxiety mothers spent more time in deep sleep and less time in quiet and active alert states and showed more state changes and less optimal performance on the Brazelton Neonatal Behavior Assessment Scale (motor maturity, autonomic stability and withdrawal). These data highlight the need for prenatal intervention for elevated anxiety symptoms during pregnancy.

AB - One hundred sixty-six women were classified as experiencing high or low anxiety during the second trimester of pregnancy. The high anxiety women also had high scores on depression and anger scales. In a follow-up across pregnancy, the fetuses of the high anxiety women were noted to be more active and to experience growth delays. The high anxiety mothers' high prenatal norepinephrine and low dopamine levels were followed by their neonates having low dopamine and serotonin levels. The high anxiety mothers' newborns also had greater relative right frontal EEG activation and lower vagal tone. Finally, the newborns of high anxiety mothers spent more time in deep sleep and less time in quiet and active alert states and showed more state changes and less optimal performance on the Brazelton Neonatal Behavior Assessment Scale (motor maturity, autonomic stability and withdrawal). These data highlight the need for prenatal intervention for elevated anxiety symptoms during pregnancy.

KW - Anger

KW - Anxiety

KW - Depression

KW - Fetus

KW - Newborn

UR - http://www.scopus.com/inward/record.url?scp=0037561862&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037561862&partnerID=8YFLogxK

U2 - 10.1002/da.10071

DO - 10.1002/da.10071

M3 - Article

VL - 17

SP - 140

EP - 151

JO - Depression and Anxiety

JF - Depression and Anxiety

SN - 1091-4269

IS - 3

ER -