Prefrontal cortical recordings with biomorphic MEAs reveal complex columnar-laminar microcircuits for BCI/BMI implementation

Ioan Opris, Joshua L. Fuqua, Greg A. Gerhardt, Robert E. Hampson, Samuel A. Deadwyler

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The mammalian prefrontal cortex known as the seat of high brain functions uses a six layer distribution of minicolumnar neurons to coordinate the integration of sensory information and the selection of relevant signals for goal driven behavior. To reveal the complex functionality of these columnar microcircuits we employed simultaneous recordings with several configurations of biomorphic microelectrode arrays (MEAs) within cortical layers in adjacent minicolumns, in four nohuman primates (NHPs) performing a delayed match-to-sample (DMS) visual discrimination task. We examined: (1) the functionality of inter-laminar, and inter-columnar interactions between pairs of cells in the same or different minicolumns by use of normalized cross-correlation histograms (CCH), (2) the modulation of glutamate concentration in layer 2/3, and (3) the potential interactions within these microcircuits. The results demonstrate that neurons in both infra-granular and supra-granular layers interact through inter-laminar loops, as well as through intra-laminar to produce behavioral response signals. These results provide new insights into the manner in which prefrontal cortical microcircuitry integrates sensory stimuli used to provide behaviorally relevant signals that may be implemented in brain computer/machine interfaces (BCI/BMIs) during performance of the task.

Original languageEnglish (US)
Pages (from-to)104-113
Number of pages10
JournalJournal of Neuroscience Methods
Volume244
DOIs
StatePublished - Apr 5 2015
Externally publishedYes

Fingerprint

Brain-Computer Interfaces
Microelectrodes
Neurons
Task Performance and Analysis
Prefrontal Cortex
Primates
Glutamic Acid
Brain

Keywords

  • Columnar processing
  • Executive control
  • Glutamate modulation
  • Microcircuits
  • Nonhuman primates
  • Prefrontal cortex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Prefrontal cortical recordings with biomorphic MEAs reveal complex columnar-laminar microcircuits for BCI/BMI implementation. / Opris, Ioan; Fuqua, Joshua L.; Gerhardt, Greg A.; Hampson, Robert E.; Deadwyler, Samuel A.

In: Journal of Neuroscience Methods, Vol. 244, 05.04.2015, p. 104-113.

Research output: Contribution to journalArticle

Opris, Ioan ; Fuqua, Joshua L. ; Gerhardt, Greg A. ; Hampson, Robert E. ; Deadwyler, Samuel A. / Prefrontal cortical recordings with biomorphic MEAs reveal complex columnar-laminar microcircuits for BCI/BMI implementation. In: Journal of Neuroscience Methods. 2015 ; Vol. 244. pp. 104-113.
@article{d4df7845767d4761872a152f9d55f7f3,
title = "Prefrontal cortical recordings with biomorphic MEAs reveal complex columnar-laminar microcircuits for BCI/BMI implementation",
abstract = "The mammalian prefrontal cortex known as the seat of high brain functions uses a six layer distribution of minicolumnar neurons to coordinate the integration of sensory information and the selection of relevant signals for goal driven behavior. To reveal the complex functionality of these columnar microcircuits we employed simultaneous recordings with several configurations of biomorphic microelectrode arrays (MEAs) within cortical layers in adjacent minicolumns, in four nohuman primates (NHPs) performing a delayed match-to-sample (DMS) visual discrimination task. We examined: (1) the functionality of inter-laminar, and inter-columnar interactions between pairs of cells in the same or different minicolumns by use of normalized cross-correlation histograms (CCH), (2) the modulation of glutamate concentration in layer 2/3, and (3) the potential interactions within these microcircuits. The results demonstrate that neurons in both infra-granular and supra-granular layers interact through inter-laminar loops, as well as through intra-laminar to produce behavioral response signals. These results provide new insights into the manner in which prefrontal cortical microcircuitry integrates sensory stimuli used to provide behaviorally relevant signals that may be implemented in brain computer/machine interfaces (BCI/BMIs) during performance of the task.",
keywords = "Columnar processing, Executive control, Glutamate modulation, Microcircuits, Nonhuman primates, Prefrontal cortex",
author = "Ioan Opris and Fuqua, {Joshua L.} and Gerhardt, {Greg A.} and Hampson, {Robert E.} and Deadwyler, {Samuel A.}",
year = "2015",
month = "4",
day = "5",
doi = "10.1016/j.jneumeth.2014.05.029",
language = "English (US)",
volume = "244",
pages = "104--113",
journal = "Journal of Neuroscience Methods",
issn = "0165-0270",
publisher = "Elsevier",

}

TY - JOUR

T1 - Prefrontal cortical recordings with biomorphic MEAs reveal complex columnar-laminar microcircuits for BCI/BMI implementation

AU - Opris, Ioan

AU - Fuqua, Joshua L.

AU - Gerhardt, Greg A.

AU - Hampson, Robert E.

AU - Deadwyler, Samuel A.

PY - 2015/4/5

Y1 - 2015/4/5

N2 - The mammalian prefrontal cortex known as the seat of high brain functions uses a six layer distribution of minicolumnar neurons to coordinate the integration of sensory information and the selection of relevant signals for goal driven behavior. To reveal the complex functionality of these columnar microcircuits we employed simultaneous recordings with several configurations of biomorphic microelectrode arrays (MEAs) within cortical layers in adjacent minicolumns, in four nohuman primates (NHPs) performing a delayed match-to-sample (DMS) visual discrimination task. We examined: (1) the functionality of inter-laminar, and inter-columnar interactions between pairs of cells in the same or different minicolumns by use of normalized cross-correlation histograms (CCH), (2) the modulation of glutamate concentration in layer 2/3, and (3) the potential interactions within these microcircuits. The results demonstrate that neurons in both infra-granular and supra-granular layers interact through inter-laminar loops, as well as through intra-laminar to produce behavioral response signals. These results provide new insights into the manner in which prefrontal cortical microcircuitry integrates sensory stimuli used to provide behaviorally relevant signals that may be implemented in brain computer/machine interfaces (BCI/BMIs) during performance of the task.

AB - The mammalian prefrontal cortex known as the seat of high brain functions uses a six layer distribution of minicolumnar neurons to coordinate the integration of sensory information and the selection of relevant signals for goal driven behavior. To reveal the complex functionality of these columnar microcircuits we employed simultaneous recordings with several configurations of biomorphic microelectrode arrays (MEAs) within cortical layers in adjacent minicolumns, in four nohuman primates (NHPs) performing a delayed match-to-sample (DMS) visual discrimination task. We examined: (1) the functionality of inter-laminar, and inter-columnar interactions between pairs of cells in the same or different minicolumns by use of normalized cross-correlation histograms (CCH), (2) the modulation of glutamate concentration in layer 2/3, and (3) the potential interactions within these microcircuits. The results demonstrate that neurons in both infra-granular and supra-granular layers interact through inter-laminar loops, as well as through intra-laminar to produce behavioral response signals. These results provide new insights into the manner in which prefrontal cortical microcircuitry integrates sensory stimuli used to provide behaviorally relevant signals that may be implemented in brain computer/machine interfaces (BCI/BMIs) during performance of the task.

KW - Columnar processing

KW - Executive control

KW - Glutamate modulation

KW - Microcircuits

KW - Nonhuman primates

KW - Prefrontal cortex

UR - http://www.scopus.com/inward/record.url?scp=84939890316&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939890316&partnerID=8YFLogxK

U2 - 10.1016/j.jneumeth.2014.05.029

DO - 10.1016/j.jneumeth.2014.05.029

M3 - Article

VL - 244

SP - 104

EP - 113

JO - Journal of Neuroscience Methods

JF - Journal of Neuroscience Methods

SN - 0165-0270

ER -