Prefrontal cortical microcircuitsfor executive control of behavior

Ioan Opris, Ioana L. Popa, Manuel F. Casanova

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

During the perception-to-action cycle, our cerebral cortex mediates the interactions between the environment and the perceptual-executive systems of the brain. At the top of the executive hierarchy, prefrontal cortical microcircuits are assumed to bind perceptual and executive control information to guide goal-driven behavior. Here, we discuss new results that show the involvement of prefrontalcortical inter-laminar microcircuits in the executive control of behavior. Recent results show that during perception and executive selection phases, cell firing in the localized prefrontal layers and caudate-putamen region exhibited a similar location preference on spatial-trials, but less on object- trials. When the perceptual-executive microcircuit became facilitated by electrically micro-stimulating the prefrontal infra-granular-cell layers with signal patterns previously derived from neuron firing in the supra-granular-layers, it was shown to produce stimulation-induced spatial preference (similar to neural tuning) in the percent correct performance only duringspatial trials. These results suggested that inter-laminar prefrontal microcircuits play causal roles to the executive control of behavior across the perceptionto- action cycle.

Original languageEnglish (US)
Title of host publicationRecent Advances On The Modular Organization Of The Cortex
PublisherSpringer Netherlands
Pages157-179
Number of pages23
ISBN (Electronic)9789401799003
ISBN (Print)9789401798990
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • Causal relationship
  • Cortex
  • Cortical microcircuits
  • Executive contro
  • MIMO model
  • Minicolumn
  • Perception-to-action
  • Prefrontal
  • Primates

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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  • Cite this

    Opris, I., Popa, I. L., & Casanova, M. F. (2015). Prefrontal cortical microcircuitsfor executive control of behavior. In Recent Advances On The Modular Organization Of The Cortex (pp. 157-179). Springer Netherlands. https://doi.org/10.1007/978-94-017-9900-3_10