Prefrontal cortical microcircuits bind perception to executive control

Ioan Opris, Lucas Santos, Greg A. Gerhardt, Dong Song, Theodore W. Berger, Robert E. Hampson, Sam A. Deadwyler

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

During the perception-to-action cycle, our cerebral cortex mediates the interactions between the environment and the perceptual-executive systems of the brain. At the top of the executive hierarchy, prefrontal cortical microcircuits are assumed to bind perceptual and executive control information to guide goal-driven behavior. Here, we tested this hypothesis by comparing simultaneously recorded neuron firing in prefrontal cortical layers and the caudate-putamen of rhesus monkeys, trained in a spatial-versus-object, rule-based match-to-sample task. We found that during the perception and executive selection phases, cell firing in the localized prefrontal layers and caudate-putamen region exhibited similar location preferences on spatial-trials, but less on object- trials. Then, we facilitated the perceptual-executive circuit by stimulating the prefrontal infra-granular-layers with patterns previously derived from supra-granular-layers, and produced stimulation-induced spatial preference in percent correct performance on spatial trials, similar to neural tuning. These results show that inter-laminar prefrontal microcircuits play causal roles to the perception-to-action cycle.

Original languageEnglish (US)
Article number2285
JournalScientific Reports
Volume3
DOIs
StatePublished - Aug 12 2013
Externally publishedYes

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Executive Function
Putamen
Macaca mulatta
Cerebral Cortex
Neurons
Brain

ASJC Scopus subject areas

  • General

Cite this

Opris, I., Santos, L., Gerhardt, G. A., Song, D., Berger, T. W., Hampson, R. E., & Deadwyler, S. A. (2013). Prefrontal cortical microcircuits bind perception to executive control. Scientific Reports, 3, [2285]. https://doi.org/10.1038/srep02285

Prefrontal cortical microcircuits bind perception to executive control. / Opris, Ioan; Santos, Lucas; Gerhardt, Greg A.; Song, Dong; Berger, Theodore W.; Hampson, Robert E.; Deadwyler, Sam A.

In: Scientific Reports, Vol. 3, 2285, 12.08.2013.

Research output: Contribution to journalArticle

Opris, I, Santos, L, Gerhardt, GA, Song, D, Berger, TW, Hampson, RE & Deadwyler, SA 2013, 'Prefrontal cortical microcircuits bind perception to executive control', Scientific Reports, vol. 3, 2285. https://doi.org/10.1038/srep02285
Opris I, Santos L, Gerhardt GA, Song D, Berger TW, Hampson RE et al. Prefrontal cortical microcircuits bind perception to executive control. Scientific Reports. 2013 Aug 12;3. 2285. https://doi.org/10.1038/srep02285
Opris, Ioan ; Santos, Lucas ; Gerhardt, Greg A. ; Song, Dong ; Berger, Theodore W. ; Hampson, Robert E. ; Deadwyler, Sam A. / Prefrontal cortical microcircuits bind perception to executive control. In: Scientific Reports. 2013 ; Vol. 3.
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