Preference-weighted health-related quality of life measures and substance use disorder severity

Jeffrey M. Pyne, Michael French, Kathryn McCollister, Shanti Tripathi, Richard Rapp, Brenda Booth

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Aims: Examine the validity of preference-weighted health-related quality of life measures in a sample of substance use disorder (SUD) patients. The implications of cost-utility analyses (CUAs) of SUD interventions are discussed. Design: Cross-sectional analysis of subjects seeking SUD treatment. Setting: Seven SUD treatment centers in a medium-sized Midwestern metropolitan area in the United States. Participants: Data from 574 SUD subjects were analyzed from a study to test interventions to improve linkage and engagement with substance abuse treatment. Measurements: Subjects completed the following preference-weighted measures: self-administered Quality of Well-Being scale (QWB-SA) and Medical Outcomes Study SF-12 (standard gamble weighted or SF-12 SG); and clinical measures: Addiction Severity Index (ASI) and a symptom checklist based on the DSM-IV. Findings: In unadjusted analyses, the QWB-SA was correlated significantly with six of seven ASI subscales and the SF-12 SG was correlated with four of seven. In adjusted analyses, both preference-weighted measures were significantly correlated with diagnostic, physical health, mental health and drug use measures, but not with legal or alcohol use measures. The QWB-SA was also correlated with employment problems and the SF-12 SG was correlated with family/social problems. Conclusions: This study generally supports the construct validity of preference-weighted health-related quality of life measures in SUD patients. However, the QWB-SA and SF-12 SG did not correlate with all ASI scales. Cost-benefit analysis may be preferable when policy-makers are interested in evaluating the full range of SUD intervention outcomes.

Original languageEnglish (US)
Pages (from-to)1320-1329
Number of pages10
JournalAddiction
Volume103
Issue number8
DOIs
StatePublished - Aug 1 2008

Keywords

  • Cost-effectiveness analysis
  • Cost-utility analysis
  • Health-related quality of life
  • Quality of wellbeing scale
  • SF-12 scale
  • Substance use disorder

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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