Predominant left hemisphere metabolic dysfunction in dementia

David Loewenstein, W. W. Barker, J. Y. Chang, A. Apicella, F. Yoshii, P. Kothari, Bonnie Levin, R. Duara

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Thirty-one patients with probably Alzheimer's disease and 11 patients with memory disorders, attributable to multiple cerebral infarctions, were studied using 18-F-fluorodeoxyglucose-positron emission tomography scans. Asymmetry in cerebral glucose metabolism within these diagnostic groups was assessed by comparison with the metabolic rates obtained in age-equivalent healthy control subjects. A significantly greater number of individuals in both patient groups exhibited predominant left rather than right hemisphere hypometabolism. In addition, for patients with Alzheimer's disease, the degree of asymmetry was not related to either the severity or duration of dementia. These findings could be explained by greater susceptibility of the left hemisphere to degenerative or ischemic brain disease, by a specific sampling effect, or most likely, by greater metabolic deficits resulting from left rather than right hemisphere impairment.

Original languageEnglish
Pages (from-to)146-152
Number of pages7
JournalArchives of Neurology
Volume46
Issue number2
StatePublished - Jan 1 1989

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Dementia
Cerebral Infarction
Fluorodeoxyglucose F18
Memory Disorders
Brain Diseases
Positron-Emission Tomography
Healthy Volunteers
Alzheimer Disease
Glucose
Left Hemisphere
Asymmetry
Alzheimer's Disease
Right Hemisphere

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Loewenstein, D., Barker, W. W., Chang, J. Y., Apicella, A., Yoshii, F., Kothari, P., ... Duara, R. (1989). Predominant left hemisphere metabolic dysfunction in dementia. Archives of Neurology, 46(2), 146-152.

Predominant left hemisphere metabolic dysfunction in dementia. / Loewenstein, David; Barker, W. W.; Chang, J. Y.; Apicella, A.; Yoshii, F.; Kothari, P.; Levin, Bonnie; Duara, R.

In: Archives of Neurology, Vol. 46, No. 2, 01.01.1989, p. 146-152.

Research output: Contribution to journalArticle

Loewenstein, D, Barker, WW, Chang, JY, Apicella, A, Yoshii, F, Kothari, P, Levin, B & Duara, R 1989, 'Predominant left hemisphere metabolic dysfunction in dementia', Archives of Neurology, vol. 46, no. 2, pp. 146-152.
Loewenstein D, Barker WW, Chang JY, Apicella A, Yoshii F, Kothari P et al. Predominant left hemisphere metabolic dysfunction in dementia. Archives of Neurology. 1989 Jan 1;46(2):146-152.
Loewenstein, David ; Barker, W. W. ; Chang, J. Y. ; Apicella, A. ; Yoshii, F. ; Kothari, P. ; Levin, Bonnie ; Duara, R. / Predominant left hemisphere metabolic dysfunction in dementia. In: Archives of Neurology. 1989 ; Vol. 46, No. 2. pp. 146-152.
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