Predominance of type II collagen in synovial chrondromatosis

L. M. Ryan, H. S. Cheung, J. P. Schwab, R. P. Johnson

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Synovial chondromas histologically consist of mature chondrocytes surrounded by metaplastic synovial lining cells and synovium. Chondromas from a patient who had synovial chondromatosis were isolated and collagen type determined by SDS gel electrophoresis and differential salt precipitation, and cyanogen bromide peptide analysis. Chondromas contained 90% Type II collagen. This collagen profile supports chondroma matrix production by chondrocytes originating from biochemically as well as histologically metaplastic subsynovial cells, or by chondrocytes derived from articular hyaline cartilage.

Original languageEnglish (US)
Pages (from-to)173-177
Number of pages5
JournalClinical orthopaedics and related research
StatePublished - Jan 1 1982
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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