Predominance of distinct viral genotypes in brain and lymph node compartments of HIV-1-infected individuals

S. Haggerty, M. Stevenson

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

A modified polymerase chain reaction protocol was used to amplify the entire envelope-coding region of HIV-1 directly from brain and lymph node tissue obtained at autopsy from three HIV-1-infected individuals. Molecular analysis of amplified DNA by digestion with 18 restriction endonucleases, singly and in combination, revealed different HIV-1 genotypes in the brain and lymph node compartments in each of the three individuals. This anatomic compartmentalization of HIV-1 populations may reflect different viral genomic sequences that determine tropism or differences in host immune selection pressures in the brain and lymphoid compartments that drive the emergence of distinct viral populations.

Original languageEnglish (US)
Pages (from-to)123-131
Number of pages9
JournalViral Immunology
Volume4
Issue number2
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Virology

Fingerprint Dive into the research topics of 'Predominance of distinct viral genotypes in brain and lymph node compartments of HIV-1-infected individuals'. Together they form a unique fingerprint.

  • Cite this