Prednisone augmentation in treatment-resistant depression with fatigue and hypocortisolaemia: A case series

Colin Bouwer, Johann Claassen, Timothy G. Dinan, Charles Nemeroff

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Abnormalities of the hypothalamic-pituitary-adrenal (HPA) axis have long been implicated in major depression with hypercortisolaemia reported in typical depression and hypocortisolaemia in some studies of atypical depression. We report on the use of prednisone in treatment-resistant depressed patients with reduced plasma cortisol concentrations. Six patients with treatment-resistant major depression were found to complain of severe fatigue, consistent with major depression, atypical subtype, and to demonstrate low plasma cortisol levels. Prednisone 7.5 mg daily was added to the antidepressant regime. Five of six patients demonstrated significant improvement in depression on prednisone augmentation of antidepressant therapy. Although hypercortisolaemia has been implicated in some patients with depression, our findings suggest that hypocortisolaemia may also play a role in some subtypes of this disorder. In treatment-resistant depressed patients with fatigue and hypocortisolaemia, prednisone augmentation may be useful. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)44-50
Number of pages7
JournalDepression and Anxiety
Volume12
Issue number1
DOIs
StatePublished - Sep 19 2000
Externally publishedYes

Fingerprint

Treatment-Resistant Depressive Disorder
Prednisone
Fatigue
Depression
Antidepressive Agents
Hydrocortisone
Therapeutics

Keywords

  • Depression
  • Ftigue
  • Hypocortisolaemia
  • Hypothalamic
  • Pitpituiry-adrena l axis
  • Prednisone

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)
  • Clinical Psychology

Cite this

Prednisone augmentation in treatment-resistant depression with fatigue and hypocortisolaemia : A case series. / Bouwer, Colin; Claassen, Johann; Dinan, Timothy G.; Nemeroff, Charles.

In: Depression and Anxiety, Vol. 12, No. 1, 19.09.2000, p. 44-50.

Research output: Contribution to journalArticle

@article{be0c0eb464f74f749e3bbe8bf7a68fdd,
title = "Prednisone augmentation in treatment-resistant depression with fatigue and hypocortisolaemia: A case series",
abstract = "Abnormalities of the hypothalamic-pituitary-adrenal (HPA) axis have long been implicated in major depression with hypercortisolaemia reported in typical depression and hypocortisolaemia in some studies of atypical depression. We report on the use of prednisone in treatment-resistant depressed patients with reduced plasma cortisol concentrations. Six patients with treatment-resistant major depression were found to complain of severe fatigue, consistent with major depression, atypical subtype, and to demonstrate low plasma cortisol levels. Prednisone 7.5 mg daily was added to the antidepressant regime. Five of six patients demonstrated significant improvement in depression on prednisone augmentation of antidepressant therapy. Although hypercortisolaemia has been implicated in some patients with depression, our findings suggest that hypocortisolaemia may also play a role in some subtypes of this disorder. In treatment-resistant depressed patients with fatigue and hypocortisolaemia, prednisone augmentation may be useful. (C) 2000 Wiley-Liss, Inc.",
keywords = "Depression, Ftigue, Hypocortisolaemia, Hypothalamic, Pitpituiry-adrena l axis, Prednisone",
author = "Colin Bouwer and Johann Claassen and Dinan, {Timothy G.} and Charles Nemeroff",
year = "2000",
month = "9",
day = "19",
doi = "10.1002/1520-6394(2000)12:1<44::AID-DA6>3.0.CO;2-C",
language = "English",
volume = "12",
pages = "44--50",
journal = "Depression and Anxiety",
issn = "1091-4269",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Prednisone augmentation in treatment-resistant depression with fatigue and hypocortisolaemia

T2 - A case series

AU - Bouwer, Colin

AU - Claassen, Johann

AU - Dinan, Timothy G.

AU - Nemeroff, Charles

PY - 2000/9/19

Y1 - 2000/9/19

N2 - Abnormalities of the hypothalamic-pituitary-adrenal (HPA) axis have long been implicated in major depression with hypercortisolaemia reported in typical depression and hypocortisolaemia in some studies of atypical depression. We report on the use of prednisone in treatment-resistant depressed patients with reduced plasma cortisol concentrations. Six patients with treatment-resistant major depression were found to complain of severe fatigue, consistent with major depression, atypical subtype, and to demonstrate low plasma cortisol levels. Prednisone 7.5 mg daily was added to the antidepressant regime. Five of six patients demonstrated significant improvement in depression on prednisone augmentation of antidepressant therapy. Although hypercortisolaemia has been implicated in some patients with depression, our findings suggest that hypocortisolaemia may also play a role in some subtypes of this disorder. In treatment-resistant depressed patients with fatigue and hypocortisolaemia, prednisone augmentation may be useful. (C) 2000 Wiley-Liss, Inc.

AB - Abnormalities of the hypothalamic-pituitary-adrenal (HPA) axis have long been implicated in major depression with hypercortisolaemia reported in typical depression and hypocortisolaemia in some studies of atypical depression. We report on the use of prednisone in treatment-resistant depressed patients with reduced plasma cortisol concentrations. Six patients with treatment-resistant major depression were found to complain of severe fatigue, consistent with major depression, atypical subtype, and to demonstrate low plasma cortisol levels. Prednisone 7.5 mg daily was added to the antidepressant regime. Five of six patients demonstrated significant improvement in depression on prednisone augmentation of antidepressant therapy. Although hypercortisolaemia has been implicated in some patients with depression, our findings suggest that hypocortisolaemia may also play a role in some subtypes of this disorder. In treatment-resistant depressed patients with fatigue and hypocortisolaemia, prednisone augmentation may be useful. (C) 2000 Wiley-Liss, Inc.

KW - Depression

KW - Ftigue

KW - Hypocortisolaemia

KW - Hypothalamic

KW - Pitpituiry-adrena l axis

KW - Prednisone

UR - http://www.scopus.com/inward/record.url?scp=0033846915&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033846915&partnerID=8YFLogxK

U2 - 10.1002/1520-6394(2000)12:1<44::AID-DA6>3.0.CO;2-C

DO - 10.1002/1520-6394(2000)12:1<44::AID-DA6>3.0.CO;2-C

M3 - Article

C2 - 10999245

AN - SCOPUS:0033846915

VL - 12

SP - 44

EP - 50

JO - Depression and Anxiety

JF - Depression and Anxiety

SN - 1091-4269

IS - 1

ER -