Abstract
Purpose: A remission of type 2 diabetes mellitus (T2DM) is one of the major goals of the contemporary bariatric surgery. The goal of our study is to identify predictors of short-term postoperative diabetes remission in order to facilitate preoperative patient selectionMaterials and Methods: Two hundred forty-five obese (body mass index (BMI) ≥35 kg/m2) T2DM subjects who underwent laparoscopic Roux-en-Y gastric bypass (RYGB) were followed up to 1 year after bariatric surgery. Diabetes remission was defined as hemoglobin A1c (HbA1c) ≤6 % and fasting blood glucose (FBG) <100 mg/dl in absence of all diabetic medications.Results: Twenty-six percent of the patients seen in f/u achieved complete remission at 1 year. Average Hba1c decreased from 8 to 6.7 % and 6.4 % after 6 and 12 months, respectively. Regression analysis showed that age (p = 0.01), number of diabetes complications (p = 0.03), family history of diabetes (p = 0.04), preoperative use of insulin (p = 0.04), and peri- and postoperative weight loss (p = 0.05, for both) were the best preoperative predictors of diabetes remission at 6 and 12 months (R<sup>2</sup> = 0.3).Conclusion: Younger patients, with fewer diabetic complications, no family history of diabetes, not using insulin, and with greater peri- and postoperative weight loss were the best candidates to achieve a rapid diabetes remission after RYGB.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 782-787 |
| Number of pages | 6 |
| Journal | Obesity Surgery |
| Volume | 25 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2015 |
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Keywords
- Diabetes remission
- Obesity
- RYGB
- Type 2 diabetes mellitus
ASJC Scopus subject areas
- Surgery
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics
Cite this
Predictors of Short-Term Diabetes Remission After Laparoscopic Roux-en-Y Gastric Bypass. / Iacobellis, Gianluca; Xu, Chengyu; Campo, Rafael E; de la Cruz-Munoz, Nestor.
In: Obesity Surgery, Vol. 25, No. 5, 01.05.2015, p. 782-787.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Predictors of Short-Term Diabetes Remission After Laparoscopic Roux-en-Y Gastric Bypass
AU - Iacobellis, Gianluca
AU - Xu, Chengyu
AU - Campo, Rafael E
AU - de la Cruz-Munoz, Nestor
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Purpose: A remission of type 2 diabetes mellitus (T2DM) is one of the major goals of the contemporary bariatric surgery. The goal of our study is to identify predictors of short-term postoperative diabetes remission in order to facilitate preoperative patient selectionMaterials and Methods: Two hundred forty-five obese (body mass index (BMI) ≥35 kg/m2) T2DM subjects who underwent laparoscopic Roux-en-Y gastric bypass (RYGB) were followed up to 1 year after bariatric surgery. Diabetes remission was defined as hemoglobin A1c (HbA1c) ≤6 % and fasting blood glucose (FBG) <100 mg/dl in absence of all diabetic medications.Results: Twenty-six percent of the patients seen in f/u achieved complete remission at 1 year. Average Hba1c decreased from 8 to 6.7 % and 6.4 % after 6 and 12 months, respectively. Regression analysis showed that age (p = 0.01), number of diabetes complications (p = 0.03), family history of diabetes (p = 0.04), preoperative use of insulin (p = 0.04), and peri- and postoperative weight loss (p = 0.05, for both) were the best preoperative predictors of diabetes remission at 6 and 12 months (R2 = 0.3).Conclusion: Younger patients, with fewer diabetic complications, no family history of diabetes, not using insulin, and with greater peri- and postoperative weight loss were the best candidates to achieve a rapid diabetes remission after RYGB.
AB - Purpose: A remission of type 2 diabetes mellitus (T2DM) is one of the major goals of the contemporary bariatric surgery. The goal of our study is to identify predictors of short-term postoperative diabetes remission in order to facilitate preoperative patient selectionMaterials and Methods: Two hundred forty-five obese (body mass index (BMI) ≥35 kg/m2) T2DM subjects who underwent laparoscopic Roux-en-Y gastric bypass (RYGB) were followed up to 1 year after bariatric surgery. Diabetes remission was defined as hemoglobin A1c (HbA1c) ≤6 % and fasting blood glucose (FBG) <100 mg/dl in absence of all diabetic medications.Results: Twenty-six percent of the patients seen in f/u achieved complete remission at 1 year. Average Hba1c decreased from 8 to 6.7 % and 6.4 % after 6 and 12 months, respectively. Regression analysis showed that age (p = 0.01), number of diabetes complications (p = 0.03), family history of diabetes (p = 0.04), preoperative use of insulin (p = 0.04), and peri- and postoperative weight loss (p = 0.05, for both) were the best preoperative predictors of diabetes remission at 6 and 12 months (R2 = 0.3).Conclusion: Younger patients, with fewer diabetic complications, no family history of diabetes, not using insulin, and with greater peri- and postoperative weight loss were the best candidates to achieve a rapid diabetes remission after RYGB.
KW - Diabetes remission
KW - Obesity
KW - RYGB
KW - Type 2 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=84939976995&partnerID=8YFLogxK
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U2 - 10.1007/s11695-014-1477-6
DO - 10.1007/s11695-014-1477-6
M3 - Article
VL - 25
SP - 782
EP - 787
JO - Obesity Surgery
JF - Obesity Surgery
SN - 0960-8923
IS - 5
ER -