Predictors of recovery of erectile function after unilateral cavernous nerve graft reconstruction at radical retropubic prostatectomy

Farhang Rabbani, Ranjith Ramasamy, Manish I. Patel, Paul Cozzi, Joseph J. Disa, Peter G. Cordeiro, Babak J. Mehrara, James A. Eastham, Peter T. Scardino, John P. Mulhall

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: Although studies have reported a benefit to bilateral cavernous nerve graft (NG) interposition, the role of unilateral NG interposition in recovery of erectile function (EF) after radical prostatectomy (RP) with unilateral neurovascular bundle (NVB) resection is more controversial. Aim: To determine the probability and predictors of EF recovery after unilateral cavernous NG at RP with unilateral NVB resection. Methods: We retrospectively reviewed the records of preoperatively potent men who underwent RP with unilateral NVB resection and ipsilateral NG without prior radiation or hormonal therapy from 1999 to 2007. Postoperative EF was defined in two ways: (i) physician interview-based assessment (level 3: erections sometimes sufficient for intercourse; level 2: erections routinely sufficient for intercourse; level 1: normal erections; all with or without oral phosphodiesterase-5 inhibitor use); and (ii) according to the sum Q3 + Q4 on the International Index of Erectile Function (IIEF) questionnaire. Main Outcome Measures: EF recovery based on physician interview-based scale and IIEF questionnaire. Results: In all, 131 men underwent unilateral NG. Median follow-up was 37.3 months. The 5-year actuarial probability of EF recovery was 46, 30, and 12% for levels 3, 2, and 1, respectively, and 40, 34, and 22% for IIEF Q3 + Q4 sum ≥6, ≥8, and = 10, respectively. On multivariate analysis, patient age, specimen weight, and plastic surgeon were predictive of EF recovery based on physician-interview whereas patient age, ethnicity, and plastic surgeon were predictive of EF recovery based on the IIEF questionnaire. Conclusions: The impact of plastic surgeon on EF recovery with unilateral NG would suggest that technical factors play a role in EF recovery after unilateral NG. Meticulous surgical technique with proper identification of proximal and distal recipient nerve endings may improve the chance of EF recovery. The variation in recovery rate among plastic surgeons would imply that there is a benefit to unilateral NG in EF recovery.

Original languageEnglish (US)
Pages (from-to)166-181
Number of pages16
JournalJournal of Sexual Medicine
Volume7
Issue number1 PART 1
DOIs
StatePublished - Jan 2010
Externally publishedYes

Fingerprint

Recovery of Function
Prostatectomy
Transplants
Interviews
Physicians
Phosphodiesterase 5 Inhibitors
Nerve Endings
Multivariate Analysis
Outcome Assessment (Health Care)
Radiation
Weights and Measures
Surgeons

Keywords

  • Cavernous nerve
  • Erectile dysfunction
  • Nerve graft
  • Prostatectomy

ASJC Scopus subject areas

  • Urology
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Predictors of recovery of erectile function after unilateral cavernous nerve graft reconstruction at radical retropubic prostatectomy. / Rabbani, Farhang; Ramasamy, Ranjith; Patel, Manish I.; Cozzi, Paul; Disa, Joseph J.; Cordeiro, Peter G.; Mehrara, Babak J.; Eastham, James A.; Scardino, Peter T.; Mulhall, John P.

In: Journal of Sexual Medicine, Vol. 7, No. 1 PART 1, 01.2010, p. 166-181.

Research output: Contribution to journalArticle

Rabbani, F, Ramasamy, R, Patel, MI, Cozzi, P, Disa, JJ, Cordeiro, PG, Mehrara, BJ, Eastham, JA, Scardino, PT & Mulhall, JP 2010, 'Predictors of recovery of erectile function after unilateral cavernous nerve graft reconstruction at radical retropubic prostatectomy', Journal of Sexual Medicine, vol. 7, no. 1 PART 1, pp. 166-181. https://doi.org/10.1111/j.1743-6109.2009.01436.x
Rabbani, Farhang ; Ramasamy, Ranjith ; Patel, Manish I. ; Cozzi, Paul ; Disa, Joseph J. ; Cordeiro, Peter G. ; Mehrara, Babak J. ; Eastham, James A. ; Scardino, Peter T. ; Mulhall, John P. / Predictors of recovery of erectile function after unilateral cavernous nerve graft reconstruction at radical retropubic prostatectomy. In: Journal of Sexual Medicine. 2010 ; Vol. 7, No. 1 PART 1. pp. 166-181.
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abstract = "Introduction: Although studies have reported a benefit to bilateral cavernous nerve graft (NG) interposition, the role of unilateral NG interposition in recovery of erectile function (EF) after radical prostatectomy (RP) with unilateral neurovascular bundle (NVB) resection is more controversial. Aim: To determine the probability and predictors of EF recovery after unilateral cavernous NG at RP with unilateral NVB resection. Methods: We retrospectively reviewed the records of preoperatively potent men who underwent RP with unilateral NVB resection and ipsilateral NG without prior radiation or hormonal therapy from 1999 to 2007. Postoperative EF was defined in two ways: (i) physician interview-based assessment (level 3: erections sometimes sufficient for intercourse; level 2: erections routinely sufficient for intercourse; level 1: normal erections; all with or without oral phosphodiesterase-5 inhibitor use); and (ii) according to the sum Q3 + Q4 on the International Index of Erectile Function (IIEF) questionnaire. Main Outcome Measures: EF recovery based on physician interview-based scale and IIEF questionnaire. Results: In all, 131 men underwent unilateral NG. Median follow-up was 37.3 months. The 5-year actuarial probability of EF recovery was 46, 30, and 12{\%} for levels 3, 2, and 1, respectively, and 40, 34, and 22{\%} for IIEF Q3 + Q4 sum ≥6, ≥8, and = 10, respectively. On multivariate analysis, patient age, specimen weight, and plastic surgeon were predictive of EF recovery based on physician-interview whereas patient age, ethnicity, and plastic surgeon were predictive of EF recovery based on the IIEF questionnaire. Conclusions: The impact of plastic surgeon on EF recovery with unilateral NG would suggest that technical factors play a role in EF recovery after unilateral NG. Meticulous surgical technique with proper identification of proximal and distal recipient nerve endings may improve the chance of EF recovery. The variation in recovery rate among plastic surgeons would imply that there is a benefit to unilateral NG in EF recovery.",
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AU - Ramasamy, Ranjith

AU - Patel, Manish I.

AU - Cozzi, Paul

AU - Disa, Joseph J.

AU - Cordeiro, Peter G.

AU - Mehrara, Babak J.

AU - Eastham, James A.

AU - Scardino, Peter T.

AU - Mulhall, John P.

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N2 - Introduction: Although studies have reported a benefit to bilateral cavernous nerve graft (NG) interposition, the role of unilateral NG interposition in recovery of erectile function (EF) after radical prostatectomy (RP) with unilateral neurovascular bundle (NVB) resection is more controversial. Aim: To determine the probability and predictors of EF recovery after unilateral cavernous NG at RP with unilateral NVB resection. Methods: We retrospectively reviewed the records of preoperatively potent men who underwent RP with unilateral NVB resection and ipsilateral NG without prior radiation or hormonal therapy from 1999 to 2007. Postoperative EF was defined in two ways: (i) physician interview-based assessment (level 3: erections sometimes sufficient for intercourse; level 2: erections routinely sufficient for intercourse; level 1: normal erections; all with or without oral phosphodiesterase-5 inhibitor use); and (ii) according to the sum Q3 + Q4 on the International Index of Erectile Function (IIEF) questionnaire. Main Outcome Measures: EF recovery based on physician interview-based scale and IIEF questionnaire. Results: In all, 131 men underwent unilateral NG. Median follow-up was 37.3 months. The 5-year actuarial probability of EF recovery was 46, 30, and 12% for levels 3, 2, and 1, respectively, and 40, 34, and 22% for IIEF Q3 + Q4 sum ≥6, ≥8, and = 10, respectively. On multivariate analysis, patient age, specimen weight, and plastic surgeon were predictive of EF recovery based on physician-interview whereas patient age, ethnicity, and plastic surgeon were predictive of EF recovery based on the IIEF questionnaire. Conclusions: The impact of plastic surgeon on EF recovery with unilateral NG would suggest that technical factors play a role in EF recovery after unilateral NG. Meticulous surgical technique with proper identification of proximal and distal recipient nerve endings may improve the chance of EF recovery. The variation in recovery rate among plastic surgeons would imply that there is a benefit to unilateral NG in EF recovery.

AB - Introduction: Although studies have reported a benefit to bilateral cavernous nerve graft (NG) interposition, the role of unilateral NG interposition in recovery of erectile function (EF) after radical prostatectomy (RP) with unilateral neurovascular bundle (NVB) resection is more controversial. Aim: To determine the probability and predictors of EF recovery after unilateral cavernous NG at RP with unilateral NVB resection. Methods: We retrospectively reviewed the records of preoperatively potent men who underwent RP with unilateral NVB resection and ipsilateral NG without prior radiation or hormonal therapy from 1999 to 2007. Postoperative EF was defined in two ways: (i) physician interview-based assessment (level 3: erections sometimes sufficient for intercourse; level 2: erections routinely sufficient for intercourse; level 1: normal erections; all with or without oral phosphodiesterase-5 inhibitor use); and (ii) according to the sum Q3 + Q4 on the International Index of Erectile Function (IIEF) questionnaire. Main Outcome Measures: EF recovery based on physician interview-based scale and IIEF questionnaire. Results: In all, 131 men underwent unilateral NG. Median follow-up was 37.3 months. The 5-year actuarial probability of EF recovery was 46, 30, and 12% for levels 3, 2, and 1, respectively, and 40, 34, and 22% for IIEF Q3 + Q4 sum ≥6, ≥8, and = 10, respectively. On multivariate analysis, patient age, specimen weight, and plastic surgeon were predictive of EF recovery based on physician-interview whereas patient age, ethnicity, and plastic surgeon were predictive of EF recovery based on the IIEF questionnaire. Conclusions: The impact of plastic surgeon on EF recovery with unilateral NG would suggest that technical factors play a role in EF recovery after unilateral NG. Meticulous surgical technique with proper identification of proximal and distal recipient nerve endings may improve the chance of EF recovery. The variation in recovery rate among plastic surgeons would imply that there is a benefit to unilateral NG in EF recovery.

KW - Cavernous nerve

KW - Erectile dysfunction

KW - Nerve graft

KW - Prostatectomy

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