Abstract
Objectives: To study the relationship between Non-Alcoholic Fatty Liver Disease (NAFLD) and sleep, Physical Activity (PA), and screen-time habits/behaviors among a multiethnic sample of overweight children/adolescents. Methods: A retrospective medical chart review (6/2013-7/2014) identified 209 patients (7-21 years old) who were overweight/obese (BMI > 85th % for age/sex). A follow-up telephone survey was completed among 130 of these patients' parents to obtain information on sleep, screen-time, PA habits, and socio-demographics. NAFLD was defined as ALT and/or AST levels above the age/sex-adjusted cutoff value in the absence of medications or associated medical conditions. Logistic regression models were fitted to identify predictors of NAFLD by adjusting age, sex, heritage, and income. Results: Over a third (34%) of the sample (N=130, 55% males, 74% Hispanic) had NAFLD. Compared to non-Hispanics, Central American heritage subjects were over three times as likely to have NAFLD compared to non-Hispanics (OR=3.90, 95% CI, 1.23-12.37) after adjusting for socio-economics and lifestyle habits. Subjects with low PA levels were at increased risk for NAFLD (aOR=4.52, 95% CI, 1.21-16.82) compared to their more active counterparts. Lower income families were over twice as likely to have NAFLD as higher income families (OR = 2.57, 0.95-6.96). Conclusions: Families residing from a Central American heritage are at significant risk for NAFLD versus their ethnic group counterparts. Identifying specific groups and risks for pediatric-onset NAFLD can inform and improve clinical practice and public health initiatives, especially as patient populations become more ethnically diverse across the nation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 130-135 |
| Number of pages | 6 |
| Journal | Current Pediatric Reviews |
| Volume | 14 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 2018 |
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Keywords
- Adolescents
- Behavior
- Diverse
- Liver disease
- Obesity
- Overweight
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Predictors of non-alcoholic liver disease in ethnically diverse overweight children and adolescents. / Botero, Pamela; Hoy, Elizabeth M.; Jimenez, Maria C.; Sengul, Tulay; Messiah, Sarah.
In: Current Pediatric Reviews, Vol. 14, No. 2, 01.01.2018, p. 130-135.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Predictors of non-alcoholic liver disease in ethnically diverse overweight children and adolescents
AU - Botero, Pamela
AU - Hoy, Elizabeth M.
AU - Jimenez, Maria C.
AU - Sengul, Tulay
AU - Messiah, Sarah
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Objectives: To study the relationship between Non-Alcoholic Fatty Liver Disease (NAFLD) and sleep, Physical Activity (PA), and screen-time habits/behaviors among a multiethnic sample of overweight children/adolescents. Methods: A retrospective medical chart review (6/2013-7/2014) identified 209 patients (7-21 years old) who were overweight/obese (BMI > 85th % for age/sex). A follow-up telephone survey was completed among 130 of these patients' parents to obtain information on sleep, screen-time, PA habits, and socio-demographics. NAFLD was defined as ALT and/or AST levels above the age/sex-adjusted cutoff value in the absence of medications or associated medical conditions. Logistic regression models were fitted to identify predictors of NAFLD by adjusting age, sex, heritage, and income. Results: Over a third (34%) of the sample (N=130, 55% males, 74% Hispanic) had NAFLD. Compared to non-Hispanics, Central American heritage subjects were over three times as likely to have NAFLD compared to non-Hispanics (OR=3.90, 95% CI, 1.23-12.37) after adjusting for socio-economics and lifestyle habits. Subjects with low PA levels were at increased risk for NAFLD (aOR=4.52, 95% CI, 1.21-16.82) compared to their more active counterparts. Lower income families were over twice as likely to have NAFLD as higher income families (OR = 2.57, 0.95-6.96). Conclusions: Families residing from a Central American heritage are at significant risk for NAFLD versus their ethnic group counterparts. Identifying specific groups and risks for pediatric-onset NAFLD can inform and improve clinical practice and public health initiatives, especially as patient populations become more ethnically diverse across the nation.
AB - Objectives: To study the relationship between Non-Alcoholic Fatty Liver Disease (NAFLD) and sleep, Physical Activity (PA), and screen-time habits/behaviors among a multiethnic sample of overweight children/adolescents. Methods: A retrospective medical chart review (6/2013-7/2014) identified 209 patients (7-21 years old) who were overweight/obese (BMI > 85th % for age/sex). A follow-up telephone survey was completed among 130 of these patients' parents to obtain information on sleep, screen-time, PA habits, and socio-demographics. NAFLD was defined as ALT and/or AST levels above the age/sex-adjusted cutoff value in the absence of medications or associated medical conditions. Logistic regression models were fitted to identify predictors of NAFLD by adjusting age, sex, heritage, and income. Results: Over a third (34%) of the sample (N=130, 55% males, 74% Hispanic) had NAFLD. Compared to non-Hispanics, Central American heritage subjects were over three times as likely to have NAFLD compared to non-Hispanics (OR=3.90, 95% CI, 1.23-12.37) after adjusting for socio-economics and lifestyle habits. Subjects with low PA levels were at increased risk for NAFLD (aOR=4.52, 95% CI, 1.21-16.82) compared to their more active counterparts. Lower income families were over twice as likely to have NAFLD as higher income families (OR = 2.57, 0.95-6.96). Conclusions: Families residing from a Central American heritage are at significant risk for NAFLD versus their ethnic group counterparts. Identifying specific groups and risks for pediatric-onset NAFLD can inform and improve clinical practice and public health initiatives, especially as patient populations become more ethnically diverse across the nation.
KW - Adolescents
KW - Behavior
KW - Diverse
KW - Liver disease
KW - Obesity
KW - Overweight
UR - http://www.scopus.com/inward/record.url?scp=85052220817&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052220817&partnerID=8YFLogxK
U2 - 10.2174/1573396314666180124101521
DO - 10.2174/1573396314666180124101521
M3 - Article
C2 - 29366420
AN - SCOPUS:85052220817
VL - 14
SP - 130
EP - 135
JO - Current Pediatric Reviews
JF - Current Pediatric Reviews
SN - 1573-3963
IS - 2
ER -