Predictors of non-alcoholic liver disease in ethnically diverse overweight children and adolescents

Pamela Botero, Elizabeth M. Hoy, Maria C. Jimenez, Tulay Koru-Sengul, Sarah E. Messiah

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Objectives: To study the relationship between Non-Alcoholic Fatty Liver Disease (NAFLD) and sleep, Physical Activity (PA), and screen-time habits/behaviors among a multiethnic sample of overweight children/adolescents. Methods: A retrospective medical chart review (6/2013-7/2014) identified 209 patients (7-21 years old) who were overweight/obese (BMI > 85th % for age/sex). A follow-up telephone survey was completed among 130 of these patients' parents to obtain information on sleep, screen-time, PA habits, and socio-demographics. NAFLD was defined as ALT and/or AST levels above the age/sex-adjusted cutoff value in the absence of medications or associated medical conditions. Logistic regression models were fitted to identify predictors of NAFLD by adjusting age, sex, heritage, and income. Results: Over a third (34%) of the sample (N=130, 55% males, 74% Hispanic) had NAFLD. Compared to non-Hispanics, Central American heritage subjects were over three times as likely to have NAFLD compared to non-Hispanics (OR=3.90, 95% CI, 1.23-12.37) after adjusting for socio-economics and lifestyle habits. Subjects with low PA levels were at increased risk for NAFLD (aOR=4.52, 95% CI, 1.21-16.82) compared to their more active counterparts. Lower income families were over twice as likely to have NAFLD as higher income families (OR = 2.57, 0.95-6.96). Conclusions: Families residing from a Central American heritage are at significant risk for NAFLD versus their ethnic group counterparts. Identifying specific groups and risks for pediatric-onset NAFLD can inform and improve clinical practice and public health initiatives, especially as patient populations become more ethnically diverse across the nation.

Original languageEnglish (US)
Pages (from-to)130-135
Number of pages6
JournalCurrent Pediatric Reviews
Issue number2
StatePublished - 2018


  • Adolescents
  • Behavior
  • Diverse
  • Liver disease
  • Obesity
  • Overweight

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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