Predictors of long-term survival in patients with glioblastoma multiforme: Advancements from the last quarter century

Nauman S. Chaudhry, Ashish H. Shah, Nicholas Ferraro, Brian M. Snelling, Amade Bregy, Karthik Madhavan, Ricardo J. Komotar

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

Over the last quarter century there has been significant progress toward identifying certain characteristics and patterns in GBM patients to predict survival times and outcomes. We sought to identify clinical predictors of survival in GBM patients from the past 24 years. We examined patient survival related to tumor locations, surgical treatment, postoperative course, radiotherapy, chemotherapy, patient age, GBM recurrence, imaging characteristics, serum, and molecular markers. We present predictors that may increase, decrease, or play no significant role in determining a GBM patient's long-term survival or affect the quality of life.

Original languageEnglish (US)
Pages (from-to)287-308
Number of pages22
JournalCancer Investigation
Volume31
Issue number5
DOIs
StatePublished - Jun 2013

Keywords

  • Brain tumors
  • Cancer biomarkers
  • CNS malignancy
  • Glioblastoma multiforme
  • Prognosis and response
  • Systematic analysis
  • Treatment

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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