Predictive value of microtubule associated proteins tau and stathmin in patients with nonmuscle invasive bladder cancer receiving adjuvant intravesical taxane therapy

Matthew S. Wosnitzer, Josep Domingo-Domenech, Mireia Castillo-Martin, Chad Ritch, Mahesh Mansukhani, Daniel P. Petrylack, Mitchell C. Benson, James M. McKiernan, Carlos Cordon-Cardo

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Purpose: After encouraging results from 2 clinical trials performed at our institution to test intravesical taxane based chemotherapy for bacillus Calmette-Guérin refractory, nonmuscle invasive bladder cancer we designed a study to identify molecular markers linked to the optimal response to such treatment modality. Materials and Methods: Included in the institutional review board approved study were 32 patients with nonmuscle invasive, bacillus Calmette-Guérin refractory bladder cancer who received intravesical taxane chemotherapy, that is docetaxel or nanoparticle albumin-bound paclitaxel. Immunophenotype analysis on tissue samples obtained before intravesical taxane therapy was done using a panel of molecular markers, including Ki-67, p53, and the microtubule associated proteins tau and stathmin. Results: Increased total tau (cytoplasmic and nuclear) and stathmin expression before intravesical taxane therapy was significantly associated with decreased recurrence-free survival (p <0.0001 and 0.007, respectively). A tau positive phenotype was an independent prognostic factor for recurrence-free survival on multivariate analysis (HR 15.66, 95% CI 2.6891.71, p = 0.002). Neither the proliferation index assessed by Ki-67 expression nor p53 status was significantly associated with recurrence-free survival. Conclusions: Assessment of tau and stathmin protein expression should be considered to select patients before intravesical taxane based chemotherapy for nonmuscle invasive, bacillus Calmette- Guérin refractory bladder cancer since those who have tumors with low tau/stathmin protein expression show a better response to therapy.

Original languageEnglish (US)
Pages (from-to)2094-2100
Number of pages7
JournalJournal of Urology
Volume186
Issue number5
DOIs
StatePublished - Nov 1 2011
Externally publishedYes

Keywords

  • BCG vaccine
  • carcinoma
  • stathmin
  • tau proteins
  • transitional cell
  • urinary bladder

ASJC Scopus subject areas

  • Urology

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    Wosnitzer, M. S., Domingo-Domenech, J., Castillo-Martin, M., Ritch, C., Mansukhani, M., Petrylack, D. P., Benson, M. C., McKiernan, J. M., & Cordon-Cardo, C. (2011). Predictive value of microtubule associated proteins tau and stathmin in patients with nonmuscle invasive bladder cancer receiving adjuvant intravesical taxane therapy. Journal of Urology, 186(5), 2094-2100. https://doi.org/10.1016/j.juro.2011.06.051