Predictive value of HLA antigen for methotrexate-induced liver damage in patients with psoriasis

Anamari Pestana; Kenneth M. Halprin; J. Richard Taylor; Eugene R. Schiff; Violet Esquenazi; Mary Comerford; Carmen Gomez

doi:10.1016/S0190-9622(85)70004-7

Predictive value of HLA antigen for methotrexate-induced liver damage in patients with psoriasis

Anamari Pestana, Kenneth M. Halprin, J. Richard Taylor, Eugene R. Schiff, Violet Esquenazi, Mary Comerford, Carmen Gomez

Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

For an investigation of a possible association between HLA antigens and postmethotrexate liver damage, the A, B, C, and Dr loci of the HLA antigens were determined in thirty-two patients with severe psoriasis who had been treated with methotrexate. There was no association between HLA antigens and increasing severity of liver disease in these patients. HLA-A3 was increased in frequency in the group of patients with the more severe liver damage but was not significant when corrected for the number of antigens tested. There appears to be no predictive value in HLA typing of psoriasis patients prior to starting methotrexate therapy.

Original language	English (US)
Pages (from-to)	26-29
Number of pages	4
Journal	Journal of the American Academy of Dermatology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/S0190-9622(85)70004-7
State	Published - 1985

ASJC Scopus subject areas

Dermatology

Access to Document

10.1016/S0190-9622(85)70004-7

Cite this

Predictive value of HLA antigen for methotrexate-induced liver damage in patients with psoriasis. / Pestana, Anamari; Halprin, Kenneth M.; Taylor, J. Richard; Schiff, Eugene R.; Esquenazi, Violet; Comerford, Mary; Gomez, Carmen.

In: Journal of the American Academy of Dermatology, Vol. 12, No. 1, 1985, p. 26-29.

Research output: Contribution to journal › Article › peer-review

@article{ff7bfd9076164ceaa83ece09d0f7de94,

title = "Predictive value of HLA antigen for methotrexate-induced liver damage in patients with psoriasis",

abstract = "For an investigation of a possible association between HLA antigens and postmethotrexate liver damage, the A, B, C, and Dr loci of the HLA antigens were determined in thirty-two patients with severe psoriasis who had been treated with methotrexate. There was no association between HLA antigens and increasing severity of liver disease in these patients. HLA-A3 was increased in frequency in the group of patients with the more severe liver damage but was not significant when corrected for the number of antigens tested. There appears to be no predictive value in HLA typing of psoriasis patients prior to starting methotrexate therapy.",

author = "Anamari Pestana and Halprin, {Kenneth M.} and Taylor, {J. Richard} and Schiff, {Eugene R.} and Violet Esquenazi and Mary Comerford and Carmen Gomez",

year = "1985",

doi = "10.1016/S0190-9622(85)70004-7",

language = "English (US)",

volume = "12",

pages = "26--29",

journal = "Journal of the American Academy of Dermatology",

issn = "0190-9622",

publisher = "Mosby Inc.",

number = "1",

}

TY - JOUR

T1 - Predictive value of HLA antigen for methotrexate-induced liver damage in patients with psoriasis

AU - Pestana, Anamari

AU - Halprin, Kenneth M.

AU - Taylor, J. Richard

AU - Schiff, Eugene R.

AU - Esquenazi, Violet

AU - Comerford, Mary

AU - Gomez, Carmen

PY - 1985

Y1 - 1985

N2 - For an investigation of a possible association between HLA antigens and postmethotrexate liver damage, the A, B, C, and Dr loci of the HLA antigens were determined in thirty-two patients with severe psoriasis who had been treated with methotrexate. There was no association between HLA antigens and increasing severity of liver disease in these patients. HLA-A3 was increased in frequency in the group of patients with the more severe liver damage but was not significant when corrected for the number of antigens tested. There appears to be no predictive value in HLA typing of psoriasis patients prior to starting methotrexate therapy.

AB - For an investigation of a possible association between HLA antigens and postmethotrexate liver damage, the A, B, C, and Dr loci of the HLA antigens were determined in thirty-two patients with severe psoriasis who had been treated with methotrexate. There was no association between HLA antigens and increasing severity of liver disease in these patients. HLA-A3 was increased in frequency in the group of patients with the more severe liver damage but was not significant when corrected for the number of antigens tested. There appears to be no predictive value in HLA typing of psoriasis patients prior to starting methotrexate therapy.

UR - http://www.scopus.com/inward/record.url?scp=0021960857&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021960857&partnerID=8YFLogxK

U2 - 10.1016/S0190-9622(85)70004-7

DO - 10.1016/S0190-9622(85)70004-7

M3 - Article

C2 - 3980800

AN - SCOPUS:0021960857

VL - 12

SP - 26

EP - 29

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

SN - 0190-9622

IS - 1

ER -

Predictive value of HLA antigen for methotrexate-induced liver damage in patients with psoriasis

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this