Predictive value of HLA antigen for methotrexate-induced liver damage in patients with psoriasis

Anamari Pestana, Kenneth M. Halprin, J. Richard Taylor, Eugene R. Schiff, Violet Esquenazi, Mary Comerford, Carmen Gomez

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

For an investigation of a possible association between HLA antigens and postmethotrexate liver damage, the A, B, C, and Dr loci of the HLA antigens were determined in thirty-two patients with severe psoriasis who had been treated with methotrexate. There was no association between HLA antigens and increasing severity of liver disease in these patients. HLA-A3 was increased in frequency in the group of patients with the more severe liver damage but was not significant when corrected for the number of antigens tested. There appears to be no predictive value in HLA typing of psoriasis patients prior to starting methotrexate therapy.

Original languageEnglish (US)
Pages (from-to)26-29
Number of pages4
JournalJournal of the American Academy of Dermatology
Volume12
Issue number1
DOIs
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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