Predictive value of HLA antigen for methotrexate-induced liver damage in patients with psoriasis

Anamari Pestana; Kenneth M. Halprin; J. Richard Taylor; Eugene R. Schiff; Violet Esquenazi; Mary Comerford; Carmen Gomez

doi:10.1016/S0190-9622(85)70004-7

Predictive value of HLA antigen for methotrexate-induced liver damage in patients with psoriasis

Anamari Pestana, Kenneth M. Halprin, J. Richard Taylor, Eugene R. Schiff, Violet Esquenazi, Mary Comerford, Carmen Gomez

Research output: Contribution to journal › Article

10 Scopus citations

Abstract

For an investigation of a possible association between HLA antigens and postmethotrexate liver damage, the A, B, C, and Dr loci of the HLA antigens were determined in thirty-two patients with severe psoriasis who had been treated with methotrexate. There was no association between HLA antigens and increasing severity of liver disease in these patients. HLA-A3 was increased in frequency in the group of patients with the more severe liver damage but was not significant when corrected for the number of antigens tested. There appears to be no predictive value in HLA typing of psoriasis patients prior to starting methotrexate therapy.

Original language	English (US)
Pages (from-to)	26-29
Number of pages	4
Journal	Journal of the American Academy of Dermatology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/S0190-9622(85)70004-7
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

Dermatology

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Pestana, A., Halprin, K. M., Taylor, J. R., Schiff, E. R., Esquenazi, V., Comerford, M., & Gomez, C. (1985). Predictive value of HLA antigen for methotrexate-induced liver damage in patients with psoriasis. Journal of the American Academy of Dermatology, 12(1), 26-29. https://doi.org/10.1016/S0190-9622(85)70004-7

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abstract = "For an investigation of a possible association between HLA antigens and postmethotrexate liver damage, the A, B, C, and Dr loci of the HLA antigens were determined in thirty-two patients with severe psoriasis who had been treated with methotrexate. There was no association between HLA antigens and increasing severity of liver disease in these patients. HLA-A3 was increased in frequency in the group of patients with the more severe liver damage but was not significant when corrected for the number of antigens tested. There appears to be no predictive value in HLA typing of psoriasis patients prior to starting methotrexate therapy.",

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AU - Esquenazi, Violet

AU - Comerford, Mary

AU - Gomez, Carmen

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