Abstract
For an investigation of a possible association between HLA antigens and postmethotrexate liver damage, the A, B, C, and Dr loci of the HLA antigens were determined in thirty-two patients with severe psoriasis who had been treated with methotrexate. There was no association between HLA antigens and increasing severity of liver disease in these patients. HLA-A3 was increased in frequency in the group of patients with the more severe liver damage but was not significant when corrected for the number of antigens tested. There appears to be no predictive value in HLA typing of psoriasis patients prior to starting methotrexate therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 26-29 |
| Number of pages | 4 |
| Journal | Journal of the American Academy of Dermatology |
| Volume | 12 |
| Issue number | 1 I |
| State | Published - Mar 6 1985 |
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ASJC Scopus subject areas
- Dermatology
Cite this
Predictive value of HLA antigen for methotrexate-induced liver damage in patients with psoriasis. / Pestana, A.; Halprin, K. M.; Taylor, J. R.; Schiff, Eugene R; Esquenazi, V.; Comerford, M.; Gomez, C.
In: Journal of the American Academy of Dermatology, Vol. 12, No. 1 I, 06.03.1985, p. 26-29.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Predictive value of HLA antigen for methotrexate-induced liver damage in patients with psoriasis
AU - Pestana, A.
AU - Halprin, K. M.
AU - Taylor, J. R.
AU - Schiff, Eugene R
AU - Esquenazi, V.
AU - Comerford, M.
AU - Gomez, C.
PY - 1985/3/6
Y1 - 1985/3/6
N2 - For an investigation of a possible association between HLA antigens and postmethotrexate liver damage, the A, B, C, and Dr loci of the HLA antigens were determined in thirty-two patients with severe psoriasis who had been treated with methotrexate. There was no association between HLA antigens and increasing severity of liver disease in these patients. HLA-A3 was increased in frequency in the group of patients with the more severe liver damage but was not significant when corrected for the number of antigens tested. There appears to be no predictive value in HLA typing of psoriasis patients prior to starting methotrexate therapy.
AB - For an investigation of a possible association between HLA antigens and postmethotrexate liver damage, the A, B, C, and Dr loci of the HLA antigens were determined in thirty-two patients with severe psoriasis who had been treated with methotrexate. There was no association between HLA antigens and increasing severity of liver disease in these patients. HLA-A3 was increased in frequency in the group of patients with the more severe liver damage but was not significant when corrected for the number of antigens tested. There appears to be no predictive value in HLA typing of psoriasis patients prior to starting methotrexate therapy.
UR - http://www.scopus.com/inward/record.url?scp=0021960857&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021960857&partnerID=8YFLogxK
M3 - Article
C2 - 3980800
AN - SCOPUS:0021960857
VL - 12
SP - 26
EP - 29
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
SN - 0190-9622
IS - 1 I
ER -