Predictive Factors for the Rate of Visual Field Progression in the Advanced Imaging for Glaucoma Study

Advanced Imaging for Glaucoma Study Group

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: To investigate predictive factors associated with the rate of visual field (VF) loss in open-angle glaucoma. Design: Prospective multicenter cohort study. Methods: Perimetric glaucoma patients of the Advanced Imaging for Glaucoma study were selected for analysis if they had 9 completed visits. Confirmed rapid significant progression (CRSP) of VF was defined as a significant (P < 0.05) negative VF index (VFI) slope of −1%/year or a mean deviation slope of −0.5 dB/year, confirmed at 2 consecutive follow-up visits. Slow progression was defined as VFI slope greater than −0.5%/year or a mean deviation slope of −0.25 dB/year. Fourier-domain optical coherence tomography (FD-OCT) measured optic disc, peripapillary retinal nerve fiber layer (NFL), and macular ganglion cell complex (GCC) thicknesses. Logistic regression was used to identify baseline predictors for CRSP and slow progression. Linear regression was used to identify baseline predictors for the VFI and mean deviation slope. Results: Eyes (n = 150) of 103 participants were included. Slow progression was observed in 80 eyes (53.3%) and CRSP in 23 eyes (15.3%). Larger NFL and GCC baseline focal loss volume (FLV), thinner central corneal thickness, and lower VFI were significant (P < 0.05) baseline predictors of more rapid progression on univariate analysis. The predictor with the highest odds ratio (OR) was NFL-FLV, which was also the most significant non-VF predictor in the multivariate analysis. Eyes with NFL-FLV >8.5% had an OR of 2.67 for CRSP and 0.42 for slow progression. Disc hemorrhage during the follow-up was also important, with an OR of 2.61 for CRSP and 0.23 for slow progression for each occurrence. Conclusions: Focal loss measured by FD-OCT or VF along with CCT are strong baseline predictors for the rate of glaucoma progression.

Original languageEnglish (US)
Pages (from-to)62-71
Number of pages10
JournalAmerican journal of ophthalmology
Volume202
DOIs
StatePublished - Jun 1 2019

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Visual Fields
Glaucoma
Open Angle Glaucoma
Multicenter Studies
Cohort Studies
Hemorrhage

ASJC Scopus subject areas

  • Ophthalmology

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Predictive Factors for the Rate of Visual Field Progression in the Advanced Imaging for Glaucoma Study. / Advanced Imaging for Glaucoma Study Group.

In: American journal of ophthalmology, Vol. 202, 01.06.2019, p. 62-71.

Research output: Contribution to journalArticle

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title = "Predictive Factors for the Rate of Visual Field Progression in the Advanced Imaging for Glaucoma Study",
abstract = "Purpose: To investigate predictive factors associated with the rate of visual field (VF) loss in open-angle glaucoma. Design: Prospective multicenter cohort study. Methods: Perimetric glaucoma patients of the Advanced Imaging for Glaucoma study were selected for analysis if they had 9 completed visits. Confirmed rapid significant progression (CRSP) of VF was defined as a significant (P < 0.05) negative VF index (VFI) slope of −1{\%}/year or a mean deviation slope of −0.5 dB/year, confirmed at 2 consecutive follow-up visits. Slow progression was defined as VFI slope greater than −0.5{\%}/year or a mean deviation slope of −0.25 dB/year. Fourier-domain optical coherence tomography (FD-OCT) measured optic disc, peripapillary retinal nerve fiber layer (NFL), and macular ganglion cell complex (GCC) thicknesses. Logistic regression was used to identify baseline predictors for CRSP and slow progression. Linear regression was used to identify baseline predictors for the VFI and mean deviation slope. Results: Eyes (n = 150) of 103 participants were included. Slow progression was observed in 80 eyes (53.3{\%}) and CRSP in 23 eyes (15.3{\%}). Larger NFL and GCC baseline focal loss volume (FLV), thinner central corneal thickness, and lower VFI were significant (P < 0.05) baseline predictors of more rapid progression on univariate analysis. The predictor with the highest odds ratio (OR) was NFL-FLV, which was also the most significant non-VF predictor in the multivariate analysis. Eyes with NFL-FLV >8.5{\%} had an OR of 2.67 for CRSP and 0.42 for slow progression. Disc hemorrhage during the follow-up was also important, with an OR of 2.61 for CRSP and 0.23 for slow progression for each occurrence. Conclusions: Focal loss measured by FD-OCT or VF along with CCT are strong baseline predictors for the rate of glaucoma progression.",
author = "{Advanced Imaging for Glaucoma Study Group} and Xinbo Zhang and Parrish, {Richard K} and David Greenfield and Francis, {Brian A.} and Rohit Varma and Schuman, {Joel S.} and Ou Tan and David Huang",
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AU - Advanced Imaging for Glaucoma Study Group

AU - Zhang, Xinbo

AU - Parrish, Richard K

AU - Greenfield, David

AU - Francis, Brian A.

AU - Varma, Rohit

AU - Schuman, Joel S.

AU - Tan, Ou

AU - Huang, David

PY - 2019/6/1

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N2 - Purpose: To investigate predictive factors associated with the rate of visual field (VF) loss in open-angle glaucoma. Design: Prospective multicenter cohort study. Methods: Perimetric glaucoma patients of the Advanced Imaging for Glaucoma study were selected for analysis if they had 9 completed visits. Confirmed rapid significant progression (CRSP) of VF was defined as a significant (P < 0.05) negative VF index (VFI) slope of −1%/year or a mean deviation slope of −0.5 dB/year, confirmed at 2 consecutive follow-up visits. Slow progression was defined as VFI slope greater than −0.5%/year or a mean deviation slope of −0.25 dB/year. Fourier-domain optical coherence tomography (FD-OCT) measured optic disc, peripapillary retinal nerve fiber layer (NFL), and macular ganglion cell complex (GCC) thicknesses. Logistic regression was used to identify baseline predictors for CRSP and slow progression. Linear regression was used to identify baseline predictors for the VFI and mean deviation slope. Results: Eyes (n = 150) of 103 participants were included. Slow progression was observed in 80 eyes (53.3%) and CRSP in 23 eyes (15.3%). Larger NFL and GCC baseline focal loss volume (FLV), thinner central corneal thickness, and lower VFI were significant (P < 0.05) baseline predictors of more rapid progression on univariate analysis. The predictor with the highest odds ratio (OR) was NFL-FLV, which was also the most significant non-VF predictor in the multivariate analysis. Eyes with NFL-FLV >8.5% had an OR of 2.67 for CRSP and 0.42 for slow progression. Disc hemorrhage during the follow-up was also important, with an OR of 2.61 for CRSP and 0.23 for slow progression for each occurrence. Conclusions: Focal loss measured by FD-OCT or VF along with CCT are strong baseline predictors for the rate of glaucoma progression.

AB - Purpose: To investigate predictive factors associated with the rate of visual field (VF) loss in open-angle glaucoma. Design: Prospective multicenter cohort study. Methods: Perimetric glaucoma patients of the Advanced Imaging for Glaucoma study were selected for analysis if they had 9 completed visits. Confirmed rapid significant progression (CRSP) of VF was defined as a significant (P < 0.05) negative VF index (VFI) slope of −1%/year or a mean deviation slope of −0.5 dB/year, confirmed at 2 consecutive follow-up visits. Slow progression was defined as VFI slope greater than −0.5%/year or a mean deviation slope of −0.25 dB/year. Fourier-domain optical coherence tomography (FD-OCT) measured optic disc, peripapillary retinal nerve fiber layer (NFL), and macular ganglion cell complex (GCC) thicknesses. Logistic regression was used to identify baseline predictors for CRSP and slow progression. Linear regression was used to identify baseline predictors for the VFI and mean deviation slope. Results: Eyes (n = 150) of 103 participants were included. Slow progression was observed in 80 eyes (53.3%) and CRSP in 23 eyes (15.3%). Larger NFL and GCC baseline focal loss volume (FLV), thinner central corneal thickness, and lower VFI were significant (P < 0.05) baseline predictors of more rapid progression on univariate analysis. The predictor with the highest odds ratio (OR) was NFL-FLV, which was also the most significant non-VF predictor in the multivariate analysis. Eyes with NFL-FLV >8.5% had an OR of 2.67 for CRSP and 0.42 for slow progression. Disc hemorrhage during the follow-up was also important, with an OR of 2.61 for CRSP and 0.23 for slow progression for each occurrence. Conclusions: Focal loss measured by FD-OCT or VF along with CCT are strong baseline predictors for the rate of glaucoma progression.

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