Predictive Factors for Late Genitourinary and Gastrointestinal Toxicity in Patients With Prostate Cancer Treated With Adjuvant or Salvage Radiotherapy

Mary Feng, Alexandra L. Hanlon, Thomas M. Pisansky, Deborah Kuban, Charles N. Catton, Jeff M. Michalski, Michael J. Zelefsky, Patrick A. Kupelian, Alan Pollack, Larry L. Kestin, Richard K. Valicenti, Theodore L. DeWeese, Howard M. Sandler

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Purpose: To determine the rate and magnitude of late genitourinary (GU) and gastrointestinal (GI) toxicities after salvage or adjuvant radiotherapy (RT) for prostate cancer, and to determine predictive factors for these toxicities. Methods and Materials: A large multi-institutional database that included 959 men who received postoperative RT after radical prostatectomy (RP) was analyzed: 19% received adjuvant RT, 81% received salvage RT, 78% were treated to the prostate bed only, and 22% received radiation to the pelvis. Results: The median follow-up time was 55 months. At 5 years, 10% of patients had Grade 2 late GU toxicity and 1% had Grade 3 late GU toxicity, while 4% of patients had Grade 2 late GI toxicity and 0.4% had Grade 3 late GI toxicity. Multivariate analysis demonstrated that adjuvant RT (p = 0.03), androgen deprivation (p < 0.0001), and prostate bed-only RT (p = 0.007) predicted for Grade 2 or higher late GU toxicity. For GI toxicity, although adjuvant RT was significant in the univariate analysis, no significant factors were found in the multivariate analysis. Conclusions: Overall, the number of high-grade toxicities for postoperative RT was low. Therefore, adjuvant and salvage RT can safely be used in the appropriate settings.

Original languageEnglish
Pages (from-to)1417-1423
Number of pages7
JournalInternational Journal of Radiation Oncology Biology Physics
Volume68
Issue number5
DOIs
StatePublished - Aug 1 2007
Externally publishedYes

Fingerprint

Adjuvant Radiotherapy
toxicity
radiation therapy
Prostatic Neoplasms
Radiotherapy
cancer
grade
Prostate
Multivariate Analysis
Prostatectomy
Pelvis
beds
Androgens
deprivation
Databases
Radiation
pelvis

Keywords

  • Adjuvant
  • Prostate cancer
  • Radiation
  • Salvage
  • Toxicity

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Predictive Factors for Late Genitourinary and Gastrointestinal Toxicity in Patients With Prostate Cancer Treated With Adjuvant or Salvage Radiotherapy. / Feng, Mary; Hanlon, Alexandra L.; Pisansky, Thomas M.; Kuban, Deborah; Catton, Charles N.; Michalski, Jeff M.; Zelefsky, Michael J.; Kupelian, Patrick A.; Pollack, Alan; Kestin, Larry L.; Valicenti, Richard K.; DeWeese, Theodore L.; Sandler, Howard M.

In: International Journal of Radiation Oncology Biology Physics, Vol. 68, No. 5, 01.08.2007, p. 1417-1423.

Research output: Contribution to journalArticle

Feng, M, Hanlon, AL, Pisansky, TM, Kuban, D, Catton, CN, Michalski, JM, Zelefsky, MJ, Kupelian, PA, Pollack, A, Kestin, LL, Valicenti, RK, DeWeese, TL & Sandler, HM 2007, 'Predictive Factors for Late Genitourinary and Gastrointestinal Toxicity in Patients With Prostate Cancer Treated With Adjuvant or Salvage Radiotherapy', International Journal of Radiation Oncology Biology Physics, vol. 68, no. 5, pp. 1417-1423. https://doi.org/10.1016/j.ijrobp.2007.01.049
Feng, Mary ; Hanlon, Alexandra L. ; Pisansky, Thomas M. ; Kuban, Deborah ; Catton, Charles N. ; Michalski, Jeff M. ; Zelefsky, Michael J. ; Kupelian, Patrick A. ; Pollack, Alan ; Kestin, Larry L. ; Valicenti, Richard K. ; DeWeese, Theodore L. ; Sandler, Howard M. / Predictive Factors for Late Genitourinary and Gastrointestinal Toxicity in Patients With Prostate Cancer Treated With Adjuvant or Salvage Radiotherapy. In: International Journal of Radiation Oncology Biology Physics. 2007 ; Vol. 68, No. 5. pp. 1417-1423.
@article{4e8d2f90c3aa4dfbbd2e3a87eb25def5,
title = "Predictive Factors for Late Genitourinary and Gastrointestinal Toxicity in Patients With Prostate Cancer Treated With Adjuvant or Salvage Radiotherapy",
abstract = "Purpose: To determine the rate and magnitude of late genitourinary (GU) and gastrointestinal (GI) toxicities after salvage or adjuvant radiotherapy (RT) for prostate cancer, and to determine predictive factors for these toxicities. Methods and Materials: A large multi-institutional database that included 959 men who received postoperative RT after radical prostatectomy (RP) was analyzed: 19{\%} received adjuvant RT, 81{\%} received salvage RT, 78{\%} were treated to the prostate bed only, and 22{\%} received radiation to the pelvis. Results: The median follow-up time was 55 months. At 5 years, 10{\%} of patients had Grade 2 late GU toxicity and 1{\%} had Grade 3 late GU toxicity, while 4{\%} of patients had Grade 2 late GI toxicity and 0.4{\%} had Grade 3 late GI toxicity. Multivariate analysis demonstrated that adjuvant RT (p = 0.03), androgen deprivation (p < 0.0001), and prostate bed-only RT (p = 0.007) predicted for Grade 2 or higher late GU toxicity. For GI toxicity, although adjuvant RT was significant in the univariate analysis, no significant factors were found in the multivariate analysis. Conclusions: Overall, the number of high-grade toxicities for postoperative RT was low. Therefore, adjuvant and salvage RT can safely be used in the appropriate settings.",
keywords = "Adjuvant, Prostate cancer, Radiation, Salvage, Toxicity",
author = "Mary Feng and Hanlon, {Alexandra L.} and Pisansky, {Thomas M.} and Deborah Kuban and Catton, {Charles N.} and Michalski, {Jeff M.} and Zelefsky, {Michael J.} and Kupelian, {Patrick A.} and Alan Pollack and Kestin, {Larry L.} and Valicenti, {Richard K.} and DeWeese, {Theodore L.} and Sandler, {Howard M.}",
year = "2007",
month = "8",
day = "1",
doi = "10.1016/j.ijrobp.2007.01.049",
language = "English",
volume = "68",
pages = "1417--1423",
journal = "International Journal of Radiation Oncology Biology Physics",
issn = "0360-3016",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Predictive Factors for Late Genitourinary and Gastrointestinal Toxicity in Patients With Prostate Cancer Treated With Adjuvant or Salvage Radiotherapy

AU - Feng, Mary

AU - Hanlon, Alexandra L.

AU - Pisansky, Thomas M.

AU - Kuban, Deborah

AU - Catton, Charles N.

AU - Michalski, Jeff M.

AU - Zelefsky, Michael J.

AU - Kupelian, Patrick A.

AU - Pollack, Alan

AU - Kestin, Larry L.

AU - Valicenti, Richard K.

AU - DeWeese, Theodore L.

AU - Sandler, Howard M.

PY - 2007/8/1

Y1 - 2007/8/1

N2 - Purpose: To determine the rate and magnitude of late genitourinary (GU) and gastrointestinal (GI) toxicities after salvage or adjuvant radiotherapy (RT) for prostate cancer, and to determine predictive factors for these toxicities. Methods and Materials: A large multi-institutional database that included 959 men who received postoperative RT after radical prostatectomy (RP) was analyzed: 19% received adjuvant RT, 81% received salvage RT, 78% were treated to the prostate bed only, and 22% received radiation to the pelvis. Results: The median follow-up time was 55 months. At 5 years, 10% of patients had Grade 2 late GU toxicity and 1% had Grade 3 late GU toxicity, while 4% of patients had Grade 2 late GI toxicity and 0.4% had Grade 3 late GI toxicity. Multivariate analysis demonstrated that adjuvant RT (p = 0.03), androgen deprivation (p < 0.0001), and prostate bed-only RT (p = 0.007) predicted for Grade 2 or higher late GU toxicity. For GI toxicity, although adjuvant RT was significant in the univariate analysis, no significant factors were found in the multivariate analysis. Conclusions: Overall, the number of high-grade toxicities for postoperative RT was low. Therefore, adjuvant and salvage RT can safely be used in the appropriate settings.

AB - Purpose: To determine the rate and magnitude of late genitourinary (GU) and gastrointestinal (GI) toxicities after salvage or adjuvant radiotherapy (RT) for prostate cancer, and to determine predictive factors for these toxicities. Methods and Materials: A large multi-institutional database that included 959 men who received postoperative RT after radical prostatectomy (RP) was analyzed: 19% received adjuvant RT, 81% received salvage RT, 78% were treated to the prostate bed only, and 22% received radiation to the pelvis. Results: The median follow-up time was 55 months. At 5 years, 10% of patients had Grade 2 late GU toxicity and 1% had Grade 3 late GU toxicity, while 4% of patients had Grade 2 late GI toxicity and 0.4% had Grade 3 late GI toxicity. Multivariate analysis demonstrated that adjuvant RT (p = 0.03), androgen deprivation (p < 0.0001), and prostate bed-only RT (p = 0.007) predicted for Grade 2 or higher late GU toxicity. For GI toxicity, although adjuvant RT was significant in the univariate analysis, no significant factors were found in the multivariate analysis. Conclusions: Overall, the number of high-grade toxicities for postoperative RT was low. Therefore, adjuvant and salvage RT can safely be used in the appropriate settings.

KW - Adjuvant

KW - Prostate cancer

KW - Radiation

KW - Salvage

KW - Toxicity

UR - http://www.scopus.com/inward/record.url?scp=34547429469&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547429469&partnerID=8YFLogxK

U2 - 10.1016/j.ijrobp.2007.01.049

DO - 10.1016/j.ijrobp.2007.01.049

M3 - Article

C2 - 17418972

AN - SCOPUS:34547429469

VL - 68

SP - 1417

EP - 1423

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

SN - 0360-3016

IS - 5

ER -