Predictions of Tissue Denaturation During Experimental Laser Interstitial Thermotherapy for Breast Tumors

Nelson Salas, Fabrice Manns, Jean-Marie A Parel, Peter J. Milne, David B. Denham, David S. Robinson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Purpose: The purpose of these preliminary experiments was to calculate the activation energy and the frequency factor constants of the Arrhenius equation for prediction of the denaturation zone produced by laser interstitial thermotherapy in female breast tissue models. Material and Methods: In a first step, pairs of parameters consisting of the activation energy (ΔE) and frequency factor (A) were calculated for different half denaturation times at 50 °C and 60 °C. Pairs of parameters were eliminated if the calculated time of denaturation at 70 °C was excessively short (<0.1s). In a second step, denaturation was calculated over time for each remaining pair of parameters using temperature measurements performed during a laser heating experiment in ex-vivo porcine mammary chain tissue. The zone of denaturation in the tissue after laser heating was 2.0 cm × 3.5 cm. One pair of Arrhenius parameters was chosen whose denaturation plot showed no denaturation outside the experimentally-observed denaturation zone, 50% denaturation at the border of the experimental denaturation zone, and 100% denaturation within the experimental denaturation zone after 1200 seconds. Results and Conclusion: The activation energy and frequency factor which best fit our experimental data were ΔE=3.02×10 5 J mol -1 and A=1.18×10 44 s -1, respectively. These values fall within the general range given in the literature.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsL.S. Bass, N Kollias, R.S. Malek, A Katzir, U.K. Shah, B.J.F. Wong, E.A. Trowers, T.A. Woodward, W.T.W. de Riese, D.S. Robinson, H-D Reidenbach, K.D. Paulsen, K.W. Gregory
Pages444-449
Number of pages6
Volume4949
DOIs
StatePublished - 2003
EventLasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIII - San Jose,CA, United States
Duration: Jan 25 2003Jan 26 2003

Other

OtherLasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIII
CountryUnited States
CitySan Jose,CA
Period1/25/031/26/03

Fingerprint

Denaturation
biopolymer denaturation
breast
Tumors
interstitials
tumors
Tissue
Lasers
predictions
lasers
Laser heating
Activation energy
laser heating
activation energy
borders
Temperature measurement
temperature measurement
plots
Experiments

Keywords

  • Breast
  • Diffusing tip
  • Fiber
  • Laser
  • Thermotherapy

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Salas, N., Manns, F., Parel, J-M. A., Milne, P. J., Denham, D. B., & Robinson, D. S. (2003). Predictions of Tissue Denaturation During Experimental Laser Interstitial Thermotherapy for Breast Tumors. In L. S. Bass, N. Kollias, R. S. Malek, A. Katzir, U. K. Shah, B. J. F. Wong, E. A. Trowers, T. A. Woodward, W. T. W. de Riese, D. S. Robinson, H-D. Reidenbach, K. D. Paulsen, ... K. W. Gregory (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4949, pp. 444-449) https://doi.org/10.1117/12.485165

Predictions of Tissue Denaturation During Experimental Laser Interstitial Thermotherapy for Breast Tumors. / Salas, Nelson; Manns, Fabrice; Parel, Jean-Marie A; Milne, Peter J.; Denham, David B.; Robinson, David S.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / L.S. Bass; N Kollias; R.S. Malek; A Katzir; U.K. Shah; B.J.F. Wong; E.A. Trowers; T.A. Woodward; W.T.W. de Riese; D.S. Robinson; H-D Reidenbach; K.D. Paulsen; K.W. Gregory. Vol. 4949 2003. p. 444-449.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Salas, N, Manns, F, Parel, J-MA, Milne, PJ, Denham, DB & Robinson, DS 2003, Predictions of Tissue Denaturation During Experimental Laser Interstitial Thermotherapy for Breast Tumors. in LS Bass, N Kollias, RS Malek, A Katzir, UK Shah, BJF Wong, EA Trowers, TA Woodward, WTW de Riese, DS Robinson, H-D Reidenbach, KD Paulsen & KW Gregory (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4949, pp. 444-449, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIII, San Jose,CA, United States, 1/25/03. https://doi.org/10.1117/12.485165
Salas N, Manns F, Parel J-MA, Milne PJ, Denham DB, Robinson DS. Predictions of Tissue Denaturation During Experimental Laser Interstitial Thermotherapy for Breast Tumors. In Bass LS, Kollias N, Malek RS, Katzir A, Shah UK, Wong BJF, Trowers EA, Woodward TA, de Riese WTW, Robinson DS, Reidenbach H-D, Paulsen KD, Gregory KW, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4949. 2003. p. 444-449 https://doi.org/10.1117/12.485165
Salas, Nelson ; Manns, Fabrice ; Parel, Jean-Marie A ; Milne, Peter J. ; Denham, David B. ; Robinson, David S. / Predictions of Tissue Denaturation During Experimental Laser Interstitial Thermotherapy for Breast Tumors. Proceedings of SPIE - The International Society for Optical Engineering. editor / L.S. Bass ; N Kollias ; R.S. Malek ; A Katzir ; U.K. Shah ; B.J.F. Wong ; E.A. Trowers ; T.A. Woodward ; W.T.W. de Riese ; D.S. Robinson ; H-D Reidenbach ; K.D. Paulsen ; K.W. Gregory. Vol. 4949 2003. pp. 444-449
@inproceedings{884168956b2048bcbfe381b8467cf3d7,
title = "Predictions of Tissue Denaturation During Experimental Laser Interstitial Thermotherapy for Breast Tumors",
abstract = "Purpose: The purpose of these preliminary experiments was to calculate the activation energy and the frequency factor constants of the Arrhenius equation for prediction of the denaturation zone produced by laser interstitial thermotherapy in female breast tissue models. Material and Methods: In a first step, pairs of parameters consisting of the activation energy (ΔE) and frequency factor (A) were calculated for different half denaturation times at 50 °C and 60 °C. Pairs of parameters were eliminated if the calculated time of denaturation at 70 °C was excessively short (<0.1s). In a second step, denaturation was calculated over time for each remaining pair of parameters using temperature measurements performed during a laser heating experiment in ex-vivo porcine mammary chain tissue. The zone of denaturation in the tissue after laser heating was 2.0 cm × 3.5 cm. One pair of Arrhenius parameters was chosen whose denaturation plot showed no denaturation outside the experimentally-observed denaturation zone, 50{\%} denaturation at the border of the experimental denaturation zone, and 100{\%} denaturation within the experimental denaturation zone after 1200 seconds. Results and Conclusion: The activation energy and frequency factor which best fit our experimental data were ΔE=3.02×10 5 J mol -1 and A=1.18×10 44 s -1, respectively. These values fall within the general range given in the literature.",
keywords = "Breast, Diffusing tip, Fiber, Laser, Thermotherapy",
author = "Nelson Salas and Fabrice Manns and Parel, {Jean-Marie A} and Milne, {Peter J.} and Denham, {David B.} and Robinson, {David S.}",
year = "2003",
doi = "10.1117/12.485165",
language = "English (US)",
volume = "4949",
pages = "444--449",
editor = "L.S. Bass and N Kollias and R.S. Malek and A Katzir and U.K. Shah and B.J.F. Wong and E.A. Trowers and T.A. Woodward and {de Riese}, W.T.W. and D.S. Robinson and H-D Reidenbach and K.D. Paulsen and K.W. Gregory",
booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",

}

TY - GEN

T1 - Predictions of Tissue Denaturation During Experimental Laser Interstitial Thermotherapy for Breast Tumors

AU - Salas, Nelson

AU - Manns, Fabrice

AU - Parel, Jean-Marie A

AU - Milne, Peter J.

AU - Denham, David B.

AU - Robinson, David S.

PY - 2003

Y1 - 2003

N2 - Purpose: The purpose of these preliminary experiments was to calculate the activation energy and the frequency factor constants of the Arrhenius equation for prediction of the denaturation zone produced by laser interstitial thermotherapy in female breast tissue models. Material and Methods: In a first step, pairs of parameters consisting of the activation energy (ΔE) and frequency factor (A) were calculated for different half denaturation times at 50 °C and 60 °C. Pairs of parameters were eliminated if the calculated time of denaturation at 70 °C was excessively short (<0.1s). In a second step, denaturation was calculated over time for each remaining pair of parameters using temperature measurements performed during a laser heating experiment in ex-vivo porcine mammary chain tissue. The zone of denaturation in the tissue after laser heating was 2.0 cm × 3.5 cm. One pair of Arrhenius parameters was chosen whose denaturation plot showed no denaturation outside the experimentally-observed denaturation zone, 50% denaturation at the border of the experimental denaturation zone, and 100% denaturation within the experimental denaturation zone after 1200 seconds. Results and Conclusion: The activation energy and frequency factor which best fit our experimental data were ΔE=3.02×10 5 J mol -1 and A=1.18×10 44 s -1, respectively. These values fall within the general range given in the literature.

AB - Purpose: The purpose of these preliminary experiments was to calculate the activation energy and the frequency factor constants of the Arrhenius equation for prediction of the denaturation zone produced by laser interstitial thermotherapy in female breast tissue models. Material and Methods: In a first step, pairs of parameters consisting of the activation energy (ΔE) and frequency factor (A) were calculated for different half denaturation times at 50 °C and 60 °C. Pairs of parameters were eliminated if the calculated time of denaturation at 70 °C was excessively short (<0.1s). In a second step, denaturation was calculated over time for each remaining pair of parameters using temperature measurements performed during a laser heating experiment in ex-vivo porcine mammary chain tissue. The zone of denaturation in the tissue after laser heating was 2.0 cm × 3.5 cm. One pair of Arrhenius parameters was chosen whose denaturation plot showed no denaturation outside the experimentally-observed denaturation zone, 50% denaturation at the border of the experimental denaturation zone, and 100% denaturation within the experimental denaturation zone after 1200 seconds. Results and Conclusion: The activation energy and frequency factor which best fit our experimental data were ΔE=3.02×10 5 J mol -1 and A=1.18×10 44 s -1, respectively. These values fall within the general range given in the literature.

KW - Breast

KW - Diffusing tip

KW - Fiber

KW - Laser

KW - Thermotherapy

UR - http://www.scopus.com/inward/record.url?scp=0141494370&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141494370&partnerID=8YFLogxK

U2 - 10.1117/12.485165

DO - 10.1117/12.485165

M3 - Conference contribution

VL - 4949

SP - 444

EP - 449

BT - Proceedings of SPIE - The International Society for Optical Engineering

A2 - Bass, L.S.

A2 - Kollias, N

A2 - Malek, R.S.

A2 - Katzir, A

A2 - Shah, U.K.

A2 - Wong, B.J.F.

A2 - Trowers, E.A.

A2 - Woodward, T.A.

A2 - de Riese, W.T.W.

A2 - Robinson, D.S.

A2 - Reidenbach, H-D

A2 - Paulsen, K.D.

A2 - Gregory, K.W.

ER -