Prediction of sudden cardiac death after myocardial infarction in the beta-blocking era

Heikki V. Huikuri, Jari M. Tapanainen, Kai Lindgren, Pekka Raatikainen, Timo H. Mäkikallio, K. E Juhani Airaksinen, Robert J Myerburg

Research output: Contribution to journalArticle

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Abstract

OBJECTIVES: This study assessed the predictive power of arrhythmia risk markers after an acute myocardial infarction (AMI). BACKGROUND: Several risk variables have been suggested to predict the occurrence of sudden cardiac death (SCD), but the utility of these variables has not been well established among patients using medical therapy according to contemporary guidelines. METHODS: A consecutive series of 700 patients with AMI was studied. The end points were total mortality, SCD, and nonsudden cardiac death (non-SCD). Nonsustained ventricular tachycardia (nsVT), ejection fraction (EF), heart rate variability, baroreflex sensitivity, signal-averaged electrocardiogram (SAECG), QT dispersion, and QRS duration were analyzed (n = 675). Beta-blocking therapy was used by 97% of the patients at discharge and by 95% at one and two years after AMI. RESULTS: During a mean (±SD) follow-up of 43 ± 15 months, 37 non-SCDs (5.5%) and 22 SCDs (3.2%) occurred. All arrhythmia risk variables differed between the survivors and those with non-SCD (e.g., the standard deviation of N-N intervals was 98 ± 32 vs. 74 ± 21 ms [p < 0.001] and the QRS duration was 103 ± 22 vs.89 ± 16 ms [p < 0.001]). Sudden cardiac death was weakly predicted only by reduced EF (<0. 40; p < 0.05), nsVT (p < 0.05), and abnormal SAECG (p < 0.05), but not by autonomic markers or standard ECG variables. The positive predictive accuracy of EF, nsVT, and abnormal SAECG as predictors of SCD was relatively low (8%, 12%, and 13%, respectively). CONCLUSIONS: The common arrhythmia risk variables, particularly the autonomic and standard ECG markers, have limited predictive power in identifying patients at risk of SCD after AMI in the beta-blocking era.

Original languageEnglish
Pages (from-to)652-658
Number of pages7
JournalJournal of the American College of Cardiology
Volume42
Issue number4
DOIs
StatePublished - Aug 20 2003

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Sudden Cardiac Death
Electrocardiography
Myocardial Infarction
Ventricular Tachycardia
Cardiac Arrhythmias
Baroreflex
Patient Discharge
Stroke Volume
Survivors
Heart Rate
Guidelines
Mortality
Therapeutics

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Huikuri, H. V., Tapanainen, J. M., Lindgren, K., Raatikainen, P., Mäkikallio, T. H., Airaksinen, K. E. J., & Myerburg, R. J. (2003). Prediction of sudden cardiac death after myocardial infarction in the beta-blocking era. Journal of the American College of Cardiology, 42(4), 652-658. https://doi.org/10.1016/S0735-1097(03)00783-6

Prediction of sudden cardiac death after myocardial infarction in the beta-blocking era. / Huikuri, Heikki V.; Tapanainen, Jari M.; Lindgren, Kai; Raatikainen, Pekka; Mäkikallio, Timo H.; Airaksinen, K. E Juhani; Myerburg, Robert J.

In: Journal of the American College of Cardiology, Vol. 42, No. 4, 20.08.2003, p. 652-658.

Research output: Contribution to journalArticle

Huikuri, HV, Tapanainen, JM, Lindgren, K, Raatikainen, P, Mäkikallio, TH, Airaksinen, KEJ & Myerburg, RJ 2003, 'Prediction of sudden cardiac death after myocardial infarction in the beta-blocking era', Journal of the American College of Cardiology, vol. 42, no. 4, pp. 652-658. https://doi.org/10.1016/S0735-1097(03)00783-6
Huikuri HV, Tapanainen JM, Lindgren K, Raatikainen P, Mäkikallio TH, Airaksinen KEJ et al. Prediction of sudden cardiac death after myocardial infarction in the beta-blocking era. Journal of the American College of Cardiology. 2003 Aug 20;42(4):652-658. https://doi.org/10.1016/S0735-1097(03)00783-6
Huikuri, Heikki V. ; Tapanainen, Jari M. ; Lindgren, Kai ; Raatikainen, Pekka ; Mäkikallio, Timo H. ; Airaksinen, K. E Juhani ; Myerburg, Robert J. / Prediction of sudden cardiac death after myocardial infarction in the beta-blocking era. In: Journal of the American College of Cardiology. 2003 ; Vol. 42, No. 4. pp. 652-658.
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abstract = "OBJECTIVES: This study assessed the predictive power of arrhythmia risk markers after an acute myocardial infarction (AMI). BACKGROUND: Several risk variables have been suggested to predict the occurrence of sudden cardiac death (SCD), but the utility of these variables has not been well established among patients using medical therapy according to contemporary guidelines. METHODS: A consecutive series of 700 patients with AMI was studied. The end points were total mortality, SCD, and nonsudden cardiac death (non-SCD). Nonsustained ventricular tachycardia (nsVT), ejection fraction (EF), heart rate variability, baroreflex sensitivity, signal-averaged electrocardiogram (SAECG), QT dispersion, and QRS duration were analyzed (n = 675). Beta-blocking therapy was used by 97{\%} of the patients at discharge and by 95{\%} at one and two years after AMI. RESULTS: During a mean (±SD) follow-up of 43 ± 15 months, 37 non-SCDs (5.5{\%}) and 22 SCDs (3.2{\%}) occurred. All arrhythmia risk variables differed between the survivors and those with non-SCD (e.g., the standard deviation of N-N intervals was 98 ± 32 vs. 74 ± 21 ms [p < 0.001] and the QRS duration was 103 ± 22 vs.89 ± 16 ms [p < 0.001]). Sudden cardiac death was weakly predicted only by reduced EF (<0. 40; p < 0.05), nsVT (p < 0.05), and abnormal SAECG (p < 0.05), but not by autonomic markers or standard ECG variables. The positive predictive accuracy of EF, nsVT, and abnormal SAECG as predictors of SCD was relatively low (8{\%}, 12{\%}, and 13{\%}, respectively). CONCLUSIONS: The common arrhythmia risk variables, particularly the autonomic and standard ECG markers, have limited predictive power in identifying patients at risk of SCD after AMI in the beta-blocking era.",
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AU - Lindgren, Kai

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AU - Mäkikallio, Timo H.

AU - Airaksinen, K. E Juhani

AU - Myerburg, Robert J

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N2 - OBJECTIVES: This study assessed the predictive power of arrhythmia risk markers after an acute myocardial infarction (AMI). BACKGROUND: Several risk variables have been suggested to predict the occurrence of sudden cardiac death (SCD), but the utility of these variables has not been well established among patients using medical therapy according to contemporary guidelines. METHODS: A consecutive series of 700 patients with AMI was studied. The end points were total mortality, SCD, and nonsudden cardiac death (non-SCD). Nonsustained ventricular tachycardia (nsVT), ejection fraction (EF), heart rate variability, baroreflex sensitivity, signal-averaged electrocardiogram (SAECG), QT dispersion, and QRS duration were analyzed (n = 675). Beta-blocking therapy was used by 97% of the patients at discharge and by 95% at one and two years after AMI. RESULTS: During a mean (±SD) follow-up of 43 ± 15 months, 37 non-SCDs (5.5%) and 22 SCDs (3.2%) occurred. All arrhythmia risk variables differed between the survivors and those with non-SCD (e.g., the standard deviation of N-N intervals was 98 ± 32 vs. 74 ± 21 ms [p < 0.001] and the QRS duration was 103 ± 22 vs.89 ± 16 ms [p < 0.001]). Sudden cardiac death was weakly predicted only by reduced EF (<0. 40; p < 0.05), nsVT (p < 0.05), and abnormal SAECG (p < 0.05), but not by autonomic markers or standard ECG variables. The positive predictive accuracy of EF, nsVT, and abnormal SAECG as predictors of SCD was relatively low (8%, 12%, and 13%, respectively). CONCLUSIONS: The common arrhythmia risk variables, particularly the autonomic and standard ECG markers, have limited predictive power in identifying patients at risk of SCD after AMI in the beta-blocking era.

AB - OBJECTIVES: This study assessed the predictive power of arrhythmia risk markers after an acute myocardial infarction (AMI). BACKGROUND: Several risk variables have been suggested to predict the occurrence of sudden cardiac death (SCD), but the utility of these variables has not been well established among patients using medical therapy according to contemporary guidelines. METHODS: A consecutive series of 700 patients with AMI was studied. The end points were total mortality, SCD, and nonsudden cardiac death (non-SCD). Nonsustained ventricular tachycardia (nsVT), ejection fraction (EF), heart rate variability, baroreflex sensitivity, signal-averaged electrocardiogram (SAECG), QT dispersion, and QRS duration were analyzed (n = 675). Beta-blocking therapy was used by 97% of the patients at discharge and by 95% at one and two years after AMI. RESULTS: During a mean (±SD) follow-up of 43 ± 15 months, 37 non-SCDs (5.5%) and 22 SCDs (3.2%) occurred. All arrhythmia risk variables differed between the survivors and those with non-SCD (e.g., the standard deviation of N-N intervals was 98 ± 32 vs. 74 ± 21 ms [p < 0.001] and the QRS duration was 103 ± 22 vs.89 ± 16 ms [p < 0.001]). Sudden cardiac death was weakly predicted only by reduced EF (<0. 40; p < 0.05), nsVT (p < 0.05), and abnormal SAECG (p < 0.05), but not by autonomic markers or standard ECG variables. The positive predictive accuracy of EF, nsVT, and abnormal SAECG as predictors of SCD was relatively low (8%, 12%, and 13%, respectively). CONCLUSIONS: The common arrhythmia risk variables, particularly the autonomic and standard ECG markers, have limited predictive power in identifying patients at risk of SCD after AMI in the beta-blocking era.

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