Prediction of pathological tumor volume in clinically localized prostate cancer: Value of endorectal coil magnetic resonance imaging

R. Lencioni, I. Menchi, A. Paolicchi, M. Carini, A. Amorosi, C. Bartolozzi

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The purpose of this study was to determine whether endorectal coil magnetic resonance imaging (MRI) enables accurate assessment of pathologic tumor volume in patients with clinically localized prostate carcinoma. Twenty-four patients with biopsy-proved prostate carcinoma underwent MRI at 0.5 T before radical prostatectomy. Tumor volumes were determined independently on axial fast-spin-echo (SE) T2-weighted MR images and whole- mount pathology slides of the surgical specimens. At pathology, tumor volumes ranged from 0.17 to 9.42 cm3 (mean ± SD, 3.11 ± 2.99 cm3): A strong correlation (r = .944) was found between measurements of tumor volume based on MR images and pathological specimens. The error was less than 0.5 cm3 in 14 cases, in the range of 0.5-1 cm3 in 7 cases, and more than 1 cm3 in 3 cases. By using an MR tumor volume of 2 cm3 as cutoff value, extracapsular tumor spread could be predicted with a sensitivity of 81.2%, a specificity of 100%, and an accuracy of 87.5%. Tumor volume determinations based on MR images seem to be accurate enough to be helpful in clinical decision-making.

Original languageEnglish (US)
Pages (from-to)117-121
Number of pages5
JournalMagnetic Resonance Materials in Physics, Biology, and Medicine
Issue number2
StatePublished - Jan 1 1997



  • Magnetic resonance
  • Neoplasms
  • Prostate
  • Surface coils

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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