Prediction of clinical response to 5-fluorouracil-containing chemotherapy: preliminary results of in vitro assay in human breast cancer.

B. Ardalan; J. Macdonald; D. Cooney; M. Lippman; P. Schein

doi:10.1007/978-3-642-81488-4_12

Prediction of clinical response to 5-fluorouracil-containing chemotherapy: preliminary results of in vitro assay in human breast cancer.

B. Ardalan, J. Macdonald, D. Cooney, M. Lippman, P. Schein

Medicine

Research output: Contribution to journal › Article

1 Scopus citations

Abstract

An in vitro assay system measuring the production of phosphorylated nucleotide products of 5-FU by human tumor cytosols is described. Samples from 11 patients with breast cancer treated with 5-FU-containing chemotherapy regimens were assayed. Significant differences were seen in quantitative and qualitative patterns of phosphorylation between samples from chemotherapy responding and nonresponding patients. The rate of 5-fluorodeoxyuridylate production and the amount of nucleotide triphosphate produced were significantly P < 0.05 increased in chemotherapy-responding patients. This in vitro assay system is a simple, reproducible procedure that requires further evaluation as a potential system for prospectively predicting clinical response to fluorinated pyrimidines.

Original language	English (US)
Pages (from-to)	84-90
Number of pages	7
Journal	Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer
Volume	74
DOIs	https://doi.org/10.1007/978-3-642-81488-4_12
State	Published - 1980

ASJC Scopus subject areas

Oncology
Cancer Research

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Ardalan, B., Macdonald, J., Cooney, D., Lippman, M., & Schein, P. (1980). Prediction of clinical response to 5-fluorouracil-containing chemotherapy: preliminary results of in vitro assay in human breast cancer. Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer, 74, 84-90. https://doi.org/10.1007/978-3-642-81488-4_12

Prediction of clinical response to 5-fluorouracil-containing chemotherapy : preliminary results of in vitro assay in human breast cancer. / Ardalan, B.; Macdonald, J.; Cooney, D.; Lippman, M.; Schein, P.

In: Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer, Vol. 74, 1980, p. 84-90.

Research output: Contribution to journal › Article

Ardalan, B, Macdonald, J, Cooney, D, Lippman, M & Schein, P 1980, 'Prediction of clinical response to 5-fluorouracil-containing chemotherapy: preliminary results of in vitro assay in human breast cancer.', Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer, vol. 74, pp. 84-90. https://doi.org/10.1007/978-3-642-81488-4_12

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