TY - JOUR
T1 - Prediction of clinical response to 5-fluorouracil-containing chemotherapy
T2 - preliminary results of in vitro assay in human breast cancer.
AU - Ardalan, B.
AU - Macdonald, J.
AU - Cooney, D.
AU - Lippman, M.
AU - Schein, P.
PY - 1980
Y1 - 1980
N2 - An in vitro assay system measuring the production of phosphorylated nucleotide products of 5-FU by human tumor cytosols is described. Samples from 11 patients with breast cancer treated with 5-FU-containing chemotherapy regimens were assayed. Significant differences were seen in quantitative and qualitative patterns of phosphorylation between samples from chemotherapy responding and nonresponding patients. The rate of 5-fluorodeoxyuridylate production and the amount of nucleotide triphosphate produced were significantly P < 0.05 increased in chemotherapy-responding patients. This in vitro assay system is a simple, reproducible procedure that requires further evaluation as a potential system for prospectively predicting clinical response to fluorinated pyrimidines.
AB - An in vitro assay system measuring the production of phosphorylated nucleotide products of 5-FU by human tumor cytosols is described. Samples from 11 patients with breast cancer treated with 5-FU-containing chemotherapy regimens were assayed. Significant differences were seen in quantitative and qualitative patterns of phosphorylation between samples from chemotherapy responding and nonresponding patients. The rate of 5-fluorodeoxyuridylate production and the amount of nucleotide triphosphate produced were significantly P < 0.05 increased in chemotherapy-responding patients. This in vitro assay system is a simple, reproducible procedure that requires further evaluation as a potential system for prospectively predicting clinical response to fluorinated pyrimidines.
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U2 - 10.1007/978-3-642-81488-4_12
DO - 10.1007/978-3-642-81488-4_12
M3 - Article
C2 - 7444153
AN - SCOPUS:0019269298
VL - 74
SP - 84
EP - 90
JO - Recent Results in Cancer Research
JF - Recent Results in Cancer Research
SN - 0080-0015
ER -
