Predicting revision sinus surgery in allergic fungal and eosinophilic mucin chronic rhinosinusitis

Ramzi T Younis, Jamal Ahmed

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Chronic rhinosinusitis consists of several disease processes. Eosinophilic mucin is found in the subtypes of allergic fungal sinusitis (AFS) and eosinophilic mucin chronic rhinosinusitis (EMCRS). These entities frequently require surgical intervention and have high recurrence rates. Objective: We aimed to determine factors in patients with AFS and EMCRS that may be associated with a higher rate of revision surgeries. Our hypothesis is that patients who have polyps, high Lund-Mackay score (LMS), and fungus may have higher revision rates. Study Design: Retrospective cohort study. Methods: This is a retrospective analysis of 117 patients identified over a 5-year period (2005-2009) with the diagnosis of AFS or EMCRS. Contingency tables were created to obtain the odds ratios estimates, and 95% confidence intervals were used to access the association between the outcome (having revision surgery or not) and other clinical binary predictors. Results: Twenty-six of 117 (22%) of the study patients underwent revision surgery. Within the 2-year follow-up period, an additional five of 26 (19%) required another revision surgery. Average LMS was slightly higher in those who underwent revision surgery (16 vs. 13) on a scale of 0 to 24, with an overall mean score of 18 and standard deviation of 6.82 for the whole sample (117). Other factors evaluated were the presence of fungus, polyps, eosinophilic mucin, and the eosinophilic count and medical therapy received. Conclusion: The presence of eosinophilic mucin was significantly associated a higher rate of revision surgery. Level of Evidence: 4. Laryngoscope, 2016

Original languageEnglish (US)
JournalLaryngoscope
DOIs
StateAccepted/In press - 2016

Fingerprint

Mucins
Reoperation
Sinusitis
Polyps
Fungi
Laryngoscopes
Cohort Studies
Retrospective Studies
Odds Ratio
Confidence Intervals
Recurrence

Keywords

  • Allergic fungal sinusitis (AFS)
  • Eosinophilic mucin chronic rhinosinusitis (EMCRS)
  • Lund-Mackay score (LMS)

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

@article{dc7127d00e534af5b53e3ef3be4f9f54,
title = "Predicting revision sinus surgery in allergic fungal and eosinophilic mucin chronic rhinosinusitis",
abstract = "Background: Chronic rhinosinusitis consists of several disease processes. Eosinophilic mucin is found in the subtypes of allergic fungal sinusitis (AFS) and eosinophilic mucin chronic rhinosinusitis (EMCRS). These entities frequently require surgical intervention and have high recurrence rates. Objective: We aimed to determine factors in patients with AFS and EMCRS that may be associated with a higher rate of revision surgeries. Our hypothesis is that patients who have polyps, high Lund-Mackay score (LMS), and fungus may have higher revision rates. Study Design: Retrospective cohort study. Methods: This is a retrospective analysis of 117 patients identified over a 5-year period (2005-2009) with the diagnosis of AFS or EMCRS. Contingency tables were created to obtain the odds ratios estimates, and 95{\%} confidence intervals were used to access the association between the outcome (having revision surgery or not) and other clinical binary predictors. Results: Twenty-six of 117 (22{\%}) of the study patients underwent revision surgery. Within the 2-year follow-up period, an additional five of 26 (19{\%}) required another revision surgery. Average LMS was slightly higher in those who underwent revision surgery (16 vs. 13) on a scale of 0 to 24, with an overall mean score of 18 and standard deviation of 6.82 for the whole sample (117). Other factors evaluated were the presence of fungus, polyps, eosinophilic mucin, and the eosinophilic count and medical therapy received. Conclusion: The presence of eosinophilic mucin was significantly associated a higher rate of revision surgery. Level of Evidence: 4. Laryngoscope, 2016",
keywords = "Allergic fungal sinusitis (AFS), Eosinophilic mucin chronic rhinosinusitis (EMCRS), Lund-Mackay score (LMS)",
author = "Younis, {Ramzi T} and Jamal Ahmed",
year = "2016",
doi = "10.1002/lary.26248",
language = "English (US)",
journal = "Laryngoscope",
issn = "0023-852X",
publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - Predicting revision sinus surgery in allergic fungal and eosinophilic mucin chronic rhinosinusitis

AU - Younis, Ramzi T

AU - Ahmed, Jamal

PY - 2016

Y1 - 2016

N2 - Background: Chronic rhinosinusitis consists of several disease processes. Eosinophilic mucin is found in the subtypes of allergic fungal sinusitis (AFS) and eosinophilic mucin chronic rhinosinusitis (EMCRS). These entities frequently require surgical intervention and have high recurrence rates. Objective: We aimed to determine factors in patients with AFS and EMCRS that may be associated with a higher rate of revision surgeries. Our hypothesis is that patients who have polyps, high Lund-Mackay score (LMS), and fungus may have higher revision rates. Study Design: Retrospective cohort study. Methods: This is a retrospective analysis of 117 patients identified over a 5-year period (2005-2009) with the diagnosis of AFS or EMCRS. Contingency tables were created to obtain the odds ratios estimates, and 95% confidence intervals were used to access the association between the outcome (having revision surgery or not) and other clinical binary predictors. Results: Twenty-six of 117 (22%) of the study patients underwent revision surgery. Within the 2-year follow-up period, an additional five of 26 (19%) required another revision surgery. Average LMS was slightly higher in those who underwent revision surgery (16 vs. 13) on a scale of 0 to 24, with an overall mean score of 18 and standard deviation of 6.82 for the whole sample (117). Other factors evaluated were the presence of fungus, polyps, eosinophilic mucin, and the eosinophilic count and medical therapy received. Conclusion: The presence of eosinophilic mucin was significantly associated a higher rate of revision surgery. Level of Evidence: 4. Laryngoscope, 2016

AB - Background: Chronic rhinosinusitis consists of several disease processes. Eosinophilic mucin is found in the subtypes of allergic fungal sinusitis (AFS) and eosinophilic mucin chronic rhinosinusitis (EMCRS). These entities frequently require surgical intervention and have high recurrence rates. Objective: We aimed to determine factors in patients with AFS and EMCRS that may be associated with a higher rate of revision surgeries. Our hypothesis is that patients who have polyps, high Lund-Mackay score (LMS), and fungus may have higher revision rates. Study Design: Retrospective cohort study. Methods: This is a retrospective analysis of 117 patients identified over a 5-year period (2005-2009) with the diagnosis of AFS or EMCRS. Contingency tables were created to obtain the odds ratios estimates, and 95% confidence intervals were used to access the association between the outcome (having revision surgery or not) and other clinical binary predictors. Results: Twenty-six of 117 (22%) of the study patients underwent revision surgery. Within the 2-year follow-up period, an additional five of 26 (19%) required another revision surgery. Average LMS was slightly higher in those who underwent revision surgery (16 vs. 13) on a scale of 0 to 24, with an overall mean score of 18 and standard deviation of 6.82 for the whole sample (117). Other factors evaluated were the presence of fungus, polyps, eosinophilic mucin, and the eosinophilic count and medical therapy received. Conclusion: The presence of eosinophilic mucin was significantly associated a higher rate of revision surgery. Level of Evidence: 4. Laryngoscope, 2016

KW - Allergic fungal sinusitis (AFS)

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KW - Lund-Mackay score (LMS)

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